COVID-19 Viral Genome Analysis Pipeline
Enabled by data from
XSpike
eXplore the Spike protein sequence in the SARS CoV-2 virus
Last update: Apr 10, 2024
Delta and Omicron Variants
Global
Wuhan reference
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Evaluating 33461 sequences of length 1741
Sampled from 2024-02-10 to 2024-04-02.
Specified Date Range: ['2024-02-10', '2024-04-10']
Highest entropy sites for: Global
Site Entropy
17 0.6562
18 0.6516
19 0.6486
20 0.6479
569 0.4068
343 0.3673
453 0.2852
452 0.2725
25 0.2295
678 0.2185
481 0.2115
1147 0.2086
155 0.2015
181 0.2005
400 0.1983
480 0.1917
936 0.1869
261 0.1853
156 0.1847
69 0.0059
210 0.1800
209 0.1764
442 0.1760
1140 0.1747
208 0.0041
126 0.1707
449 0.1707
51 0.1652
144 0.1636
478 0.1564
551 0.1516
213 0.1510
618 0.1462
567 0.1450
353 0.1441
82 0.1410
242 0.1406
329 0.1398
447 0.1371
487 0.1366
365 0.1309
249 0.1218
1101 0.1162
28 0.1069
405 0.1022
53 0.1014
475 0.0996
23 0.0885
32 0.0843
Most highly correlated site-pairs for: Global
cramerV mutInfo
19 20 1.0000 0.6466
18 19 0.7236 0.6460
18 20 0.7069 0.6453
17 18 0.5830 0.6452
17 19 0.7192 0.6446
17 20 0.7065 0.6437
155 156 0.9923 0.1748
481 480 0.7759 0.1630
210 209 0.7125 0.1400
442 449 0.4888 0.1387
481 478 0.5542 0.1356
481 442 0.4370 0.1338
936 1140 0.6231 0.1312
481 487 0.6911 0.1297
442 478 0.5508 0.1289
181 365 0.9798 0.1211
487 365 0.9774 0.1229
481 329 0.9732 0.1282
82 365 0.9724 0.1214
442 365 0.9714 0.1230
481 365 0.9676 0.1225
481 567 0.9647 0.1283
329 365 0.9609 0.1210
353 329 0.9591 0.1255
329 487 0.9551 0.1209
442 329 0.9540 0.1256
618 329 0.9529 0.1228
242 329 0.9524 0.1195
618 365 0.9505 0.1178
618 567 0.9496 0.1246
Most common patterns for local area, where Local = Global
111
1111122222223333444444444444555669111
1112222355682455800114462456004445577888566173044
7890358213926456189032919335052792358017179886107
MPLFITSSLQIVFHSGQIIGFNGXVRTLKSHDWSFKKXKFKVTSRFVXE Global UK Eu-UK NAmer Asia Africa SAmer Ocean Local Exact Pct [Context]
0 2904 2948 17718 7456 265 733 1437 21833 <----------- Totals
.......................D.............-.........L. 0 183 763 7509 1828 6 208 503 11000 7019 63% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
----...................D.............-.........L. 0 23 84 627 1841 2 78 63 2718 1835 67% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......................D.............-....I....L. 0 39 87 920 56 0 11 70 1183 859 72% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,T569I,X1140L]
.......................D.............-....I....LD 0 33 76 701 24 0 47 9 890 706 79% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,T569I,X1140L,E1147D]
.......................D.T...........-.........L. 0 6 29 519 51 17 3 13 638 250 39% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,X480-,X1140L]
.......................D..........L..-.........L. 0 7 21 199 68 0 7 17 319 228 71% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,F453L,X480-,X1140L]
.......................D.........L...-.........L. 0 9 22 32 194 0 0 16 273 128 46% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,S452L,X480-,X1140L]
----.R..SH.AVQFRE.LELHVAITKIR.PNLFL.NVASEA.PHS.P. 0 2 5 28 170 0 3 11 219 38 17% [Q14K,M17-,P18-,L19-,F20-,T25R,L51S,Q53H,+69HV,V82A,F126V,X141D,H144Q,S155F,G156R,Q181E,+208N,I209L,G210E,F213L,N242H,G249V,X258G,X259A,X260A,X261A,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,V329I,R343T,T353K,L365I,K400R,H442P,D447N,W449L,S452F,F453L,K478N,X480V,K481A,F487S,K551E,V567A,S618P,R678H,F936S,X1140P]
.......................D.T........L..-........LL. 0 8 10 161 13 0 0 7 199 55 27% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,F453L,X480-,V1101L,X1140L]
.......................D.....R.......-.........L. 0 0 8 157 20 0 14 0 199 145 72% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,S405R,X480-,X1140L]
----...................D.............-....I....L. 0 3 13 117 47 0 2 7 189 132 69% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,T569I,X1140L]
.......................D..........L..-........LL. 0 4 2 165 8 0 0 5 184 57 30% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,F453L,X480-,V1101L,X1140L]
................H......D.............-.........L. 0 3 4 115 8 0 1 1 132 99 75% [X141D,Q181H,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
----...................D.............-....I....LD 0 4 14 81 4 0 16 0 119 76 63% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,T569I,X1140L,E1147D]
.......................D.T........L..-.........L. 0 6 11 79 9 2 0 10 117 32 27% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,F453L,X480-,X1140L]
----...F...............D.............-.........L. 0 0 0 0 109 0 1 0 110 87 79% [M17-,P18-,L19-,F20-,S32F,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......F...............D.............-.........L. 0 1 10 42 38 0 2 16 109 70 64% [S32F,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......................D.T...........-....I....L. 0 0 1 104 0 0 0 0 105 62 59% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,X480-,T569I,X1140L]
----...................D.T...........-.........L. 0 5 4 49 21 18 0 0 97 55 56% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,X480-,X1140L]
----.R..SH.AVQFRE.LELHVAITKIR.P.LFL.NVASEA.PHS.P. 0 0 0 62 14 0 0 17 93 35 37% [M17-,P18-,L19-,F20-,T25R,L51S,Q53H,+69HV,V82A,F126V,X141D,H144Q,S155F,G156R,Q181E,+208N,I209L,G210E,F213L,N242H,G249V,X258G,X259A,X260A,X261A,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,V329I,R343T,T353K,L365I,K400R,H442P,W449L,S452F,F453L,K478N,X480V,K481A,F487S,K551E,V567A,S618P,R678H,S701L,F936S,X1140P]
----...................D..........L..-.........L. 0 0 3 4 82 0 0 1 90 60 66% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,F453L,X480-,X1140L]
.......................D.............-......-..L. 0 1 1 65 13 0 1 7 88 13 14% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,R678-,+680Q,X1140L]
.......................D.........L...-.......S.P. 0 0 0 5 80 0 0 2 87 33 37% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,S452L,A472V,X480-,F936S,X1140P]
----.R..S..AVQFRE.LELHVAITKIR.PNLFL.NVASEA.PHS.P. 0 4 6 25 8 0 19 0 62 12 19% [M17-,P18-,L19-,F20-,T25R,L51S,+69HV,V82A,F126V,X141D,H144Q,S155F,G156R,Q181E,+208N,I209L,G210E,F213L,N242H,G249V,X258G,X259A,X260A,X261A,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,V329I,R343T,T353K,L365I,K400R,H442P,D447N,W449L,S452F,F453L,A472V,K478N,X480V,K481A,F487S,K551E,V567A,S618P,R678H,F936S,X1140P]
----.R..SH.AVQLRE.LELHVAITKIR.PNRLL.NVASEA.PHS.P. 0 3 1 40 8 0 5 0 57 21 36% [M17-,P18-,L19-,F20-,T25R,L51S,Q53H,+69HV,V82A,F126V,X141D,H144Q,S155L,G156R,Q181E,+208N,I209L,G210E,F213L,N242H,G249V,X258G,X259A,X260A,X261A,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,V329I,R343T,T353K,L365I,K400R,H442P,D447N,W449R,S452L,F453L,K478N,X480V,K481A,F487S,K551E,V567A,S618P,R678H,F936S,X1140P]
----.R..S..AVQFRE.LELH.AITKIR.PNLL.TNVASEA.PHS.P. 0 31 0 24 0 1 0 0 56 23 41% [M17-,P18-,L19-,F20-,T25R,L51S,+69HV,K76R,V82A,F126V,X141D,H144Q,N146T,S155F,G156R,Q181E,N183I,F184-,+208N,I209L,G210E,F213L,N242H,D250G,X258G,X259A,X260A,X261A,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,V329I,R343T,T353K,L365I,+371F,F372S,A373-,K400R,H442P,D447N,W449L,S452L,K475T,K478N,X480V,K481A,F487S,P518S,K551E,V567A,S618P,R678H,F936S,X1140P]
.............Q.........D.............-....I....L. 0 0 0 53 0 0 0 0 53 42 79% [X141D,H144Q,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,T569I,X1140L]
.......................D.............-..E......L. 0 0 2 40 5 0 0 0 47 35 74% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,K551E,X1140L]
......-................D.............-.........L. 0 1 1 16 27 0 0 0 45 28 62% [+27L,S28-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......................D.............VE........L. 0 0 0 0 45 0 0 0 45 26 57% [+27XXX,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480V,K481E,X1140L]
.......................D.............-........LL. 0 0 2 30 5 0 0 2 39 19 48% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,V1101L,X1140L]
........S..............D.............-.........L. 0 0 25 7 5 0 0 0 37 25 67% [L51S,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
----T-.................D.............-.........L. 0 0 2 12 17 0 3 2 36 10 27% [M17-,P18-,L19-,F20-,N21M,+21P,+22FNFI,I23T,T25-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.....-.................D.............-.........L. 0 0 1 31 2 0 1 0 35 18 51% [T25-,+26N,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.............-.........D.............-.........L. 0 1 3 19 2 0 0 9 34 21 61% [X141D,+142Y,H144-,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......................D.............-......H..L. 0 0 2 17 11 0 1 1 32 14 43% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,R678H,X1140L]
.......................D.............V.........L. 0 0 0 2 1 0 29 0 32 14 43% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,F368S,N414K,X480V,X1140L]
.......................D....R........-.........L. 0 0 5 13 6 3 3 0 30 12 40% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,K400R,X480-,X1140L]
----...................D.T..R........-.........L. 0 0 0 0 1 28 0 0 29 22 75% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,K400R,X480-,X1140L]
----...................D.............-...A.....L. 0 0 0 3 25 0 0 0 28 25 89% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,V567A,X1140L]
----....S..............D.............-.........L. 0 0 18 0 7 0 0 0 25 14 56% [M17-,P18-,L19-,F20-,L51S,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
----...................D.........L...-.........L. 0 5 3 5 7 0 0 5 25 12 48% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,S452L,X480-,X1140L]
.......................D.I...........-.........L. 0 0 1 21 0 3 0 0 25 20 80% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343I,X480-,X1140L]
.......................D.............-......P..L. 0 0 1 12 9 0 1 1 24 11 45% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,S677-,R678P,+680R,X1140L]
.......................D.S...........-.........L. 0 0 0 22 2 0 0 0 24 8 33% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343S,X480-,X1140L]
----..-................D.............-.........L. 0 2 0 2 19 0 0 0 23 19 82% [M17-,P18-,L19-,F20-,+27L,S28-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
----.R..S..AVQFRE.LELHVAITKIR.PNLL.RNVASEA.PHS.P. 0 0 12 5 5 0 0 0 22 4 18% [M17-,P18-,L19-,F20-,T25R,L51S,+69HV,V82A,F126V,E131Q,X141D,H144Q,S155F,G156R,E178V,Q181E,+208N,I209L,G210E,F213L,Q215R,N242H,G249V,X258G,X259A,X260A,X261A,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,V329I,R343T,T353K,L365I,K400R,H442P,D447N,W449L,S452L,K475R,K478N,X480V,K481A,F487S,P518S,K551E,V567A,S618P,R678H,F936S,K1042R,G1128E,X1140P,V1261M]
----...................D....R........-.........L. 0 0 0 0 19 3 0 0 22 17 77% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,K400R,X480-,X1140L]
............V..........D.............-.........L. 0 0 0 20 0 0 0 0 20 6 30% [F126V,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,T958X,L959X,V960X,X1140L]
....TR.................D.............-.........L. 0 0 20 0 0 0 0 0 20 16 80% [I23T,T25R,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
----...................D.........L...-.......S.P. 0 0 0 0 19 0 0 0 19 13 68% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,S452L,A472V,X480-,F936S,X1140P]
.......................D.....R.......-....I....L. 0 0 1 18 0 0 0 0 19 15 78% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,S405R,X480-,T569I,X1140L]
.......................D..........L..-....I....L. 0 0 5 5 1 0 0 7 18 9 50% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,F453L,X480-,T569I,X1140L]
.......................D.....R.......-....I....LD 0 0 0 16 1 0 0 0 17 12 70% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,S405R,X480-,T569I,X1140L,E1147D]
...................E...D.T...........-....I....L. 0 0 0 14 0 0 0 3 17 14 82% [X141D,G210E,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,X480-,T569I,X1140L]
.......................A.............-.........L. 0 0 1 15 0 0 1 0 17 7 41% [X141D,X258-,X259A,X260A,X261A,+261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......................D.....R.......-..E......L. 0 0 0 15 2 0 0 0 17 7 41% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,S405R,X480-,K551E,X1140L]
----TRA................D.............-.........L. 0 0 8 3 5 0 0 0 16 7 43% [M17-,P18-,L19-,F20-,I23T,T25R,+27LPP,S28A,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
................H......D.............-....I....L. 0 5 0 8 0 0 0 2 15 11 73% [X141D,Q181H,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,T569I,X1140L]
----...................D.............-......H..L. 0 2 0 0 11 0 1 1 15 5 33% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,R678H,X1140L]
I......................D.............-.........L. 0 0 2 12 1 0 0 0 15 10 66% [M17I,S61P,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......-...............D.T...........-.........L. 0 0 5 7 0 0 0 2 14 6 42% [S32-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,X480-,X1140L]
..................--...D.............-.........L. 0 0 3 8 3 0 0 0 14 4 28% [X141D,+207V,+208G,I209-,G210-,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
----...................D..K..........-.........L. 0 0 0 0 0 0 0 14 14 9 64% [L5X,M17-,P18-,L19-,F20-,C135X,W255X,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X316R,X318Q,T353K,V364X,Q411X,X480-,S940X,D947X,G1121X,X1140L,W1211X]
.......................D.............-.....P...L. 0 0 0 12 1 0 0 0 13 12 92% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,S618P,X1140L]
----...................D.T........L..-.........L. 0 0 1 7 3 0 1 1 13 6 46% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,F453L,X480-,X1140L]
.......................D.........L...-........LL. 0 0 0 0 13 0 0 0 13 6 46% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,S452L,X480-,V1101L,X1140L]
----..............L....D.............-.........L. 0 0 12 1 0 0 0 0 13 8 61% [M17-,P18-,L19-,F20-,X141D,+208N,I209L,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......................D.............-....I.-..L. 0 0 0 13 0 0 0 0 13 3 23% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,T569I,R678-,+680Q,X1140L]
----...................D.....R.......-.........L. 0 0 0 2 2 0 9 0 13 11 84% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,S405R,X480-,X1140L]
..............L........D.............-.........L. 0 0 0 11 0 0 0 1 12 6 50% [X141D,S155L,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
..............FR.......D.............-.........L. 0 0 1 3 7 0 1 0 12 2 16% [X141D,S155F,G156R,+156X,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......................D.T........V..-.........L. 0 0 1 11 0 0 0 0 12 6 50% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,F453V,X480-,X1140L]
.......................D......VNLL...-.........L. 0 0 0 5 7 0 0 0 12 3 25% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,K437N,H442V,S443G,D447N,W449L,S452L,K457N,X480-,X1140L]
....TRA................D.............-.........L. 0 0 12 0 0 0 0 0 12 7 58% [I23T,T25R,+27LPP,S28A,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
----.R..S..AVQFRE.LELH.AITKIR.PNLL.RNVASEA.PHS.P. 0 1 8 2 0 0 0 0 11 2 18% [M17-,P18-,L19-,F20-,T25R,L51S,+69HV,V82A,F126V,X141D,H144Q,S155F,G156R,Q181E,N183D,+208N,I209L,G210E,F213L,N242H,D250G,X258G,X259A,X260A,X261A,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,V329I,R343T,T353K,L365I,K400R,H442P,D447N,W449L,S452L,K475R,K478N,X480V,K481A,F487S,P518S,K551E,V567A,S618P,R678H,F936S,X1140P]
----...................D.............-......-..L. 0 0 0 2 8 0 0 1 11 3 27% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,R678-,+680W,X1140L]
----............H......D.............-.........L. 0 0 0 9 2 0 0 0 11 8 72% [M17-,P18-,L19-,F20-,X141D,Q181H,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
----.R..S..AVQFRE.LELHVAITKI..PNLL.RNVASEA.PHS.P. 0 0 0 11 0 0 0 0 11 7 63% [M17-,P18-,L19-,F20-,T25R,L51S,+69HV,V82A,F126V,X141D,H144Q,S155F,G156R,Q171K,Q181E,+208N,I209L,G210E,F213L,N242H,G249V,X258G,X259A,X260A,X261A,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,V329I,L332S,R343T,T353K,L365I,H442P,D447N,W449L,S452L,K475R,K478N,X480V,K481A,F487S,K551E,V567A,S618P,R678H,F936S,X1140P]
.......-...............D.............-.........L. 0 0 0 9 1 0 0 0 10 3 30% [S32-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......................D...........T.-.........L. 0 0 1 4 4 0 0 1 10 4 40% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,K475T,X480-,X1140L]
..................GH...D.............-.........L. 0 0 0 9 1 0 0 0 10 6 60% [X141D,+208I,I209G,G210H,R211-,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
.......................D.T...R.......-.........L. 0 0 1 7 2 0 0 0 10 5 50% [F60S,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,S405R,X480-,A1084S,X1140L]
.....R.................D.............-.........L. 0 0 8 2 0 0 0 0 10 7 70% [T25R,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,X480-,X1140L]
----...................D.T...........-....I....L. 0 0 0 10 0 0 0 0 10 8 80% [M17-,P18-,L19-,F20-,X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,R343T,X480-,T569I,X1140L]
.......................D............R-.........L. 0 0 0 7 2 0 1 0 10 4 40% [X141D,X258G,X259A,X260A,X261D,X262Y,X263Y,X264V,X265G,X266Y,X267L,X268Q,X269P,X270R,X271T,X272F,X273L,X274L,X275K,X276Y,X277N,X278E,X279N,X280G,X281T,X282I,X283T,X284D,X285A,X286V,X287D,X288C,X289A,X290L,X291D,X292P,X293L,X294S,X295E,X296T,X297K,X298C,X299T,X300L,X301K,X302S,X303F,X304T,X305V,X306E,X307K,X308G,X309I,X310Y,X311Q,X312T,X313S,X314N,X315F,X316R,X317V,X318Q,K478R,X480-,X1140L]
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last modified: Wed May 24 14:07 2023
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Questions or comments? Contact us at seq-info@lanl.gov.