COVID-19 Viral Genome Analysis Pipeline
Enabled by data from
XSpike
eXplore the Spike protein sequence in the SARS CoV-2 virus
Last update: May 10, 2024
Delta and Omicron Variants
Global
Wuhan reference
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Evaluating 27886 sequences of length 1749
Sampled from 2024-03-11 to 2024-05-04.
Specified Date Range: ['2024-03-11', '2024-05-10']
Highest entropy sites for: Global
Site Entropy
16 0.0068
456 0.5998
346 0.5832
572 0.5049
1104 0.3828
1150 0.2833
455 0.2643
484 0.2199
21 0.2191
1143 0.2007
939 0.1970
681 0.1836
59 0.1737
483 0.1645
183 0.1645
31 0.1520
493 0.1406
213 0.1368
19 0.1306
146 0.1301
27 0.1296
211 0.1266
1087 0.1260
445 0.1257
212 0.1256
403 0.1229
157 0.1223
69 0.1202
1086 0.1188
158 0.1183
127 0.1112
452 0.1100
264 0.1068
70 0.1050
481 0.1020
50 0.1006
450 0.0922
216 0.0915
554 0.0914
621 0.0890
356 0.0885
332 0.0881
24 0.0880
245 0.0877
475 0.0869
570 0.0865
680 0.0797
Most highly correlated site-pairs for: Global
cramerV mutInfo
456 1104 0.4489 0.1863
1143 939 0.9253 0.1580
455 939 0.8364 0.1438
455 1143 0.4166 0.1411
572 1150 0.5849 0.1410
484 483 0.7453 0.1217
211 212 0.8223 0.1171
157 158 0.9922 0.1078
59 1087 0.8855 0.1058
456 346 0.3391 0.1046
69 70 0.9842 0.0919
452 450 0.9245 0.0811
445 452 0.5331 0.0761
69 570 0.9195 0.0757
621 570 0.9502 0.0754
484 570 0.9488 0.0716 484 332 0.9339 0.0700 356 332 0.9298 0.0728 245 570 0.9255 0.0692 216 245 0.9254 0.0704 332 570 0.9197 0.0708 183 570 0.9126 0.0652 621 332 0.9125 0.0700 332 245 0.9121 0.0681 216 570 0.9085 0.0705 183 332 0.9027 0.0649 484 264 0.9017 0.0647 183 216 0.9006 0.0667 356 570 0.8972 0.0674 216 332 0.8962 0.0692
Most common patterns for local area, where Local = Global
11111
1111122222233344444444444555666900111
11222355672455811114634504555578889577288388045
69147109907678312365426635025651343402101967430
VTRLASSFHVVHFRQNLVLHAIRKRVNLLFANVEQEATPSPSKAVPE Global UK Eu-UK NAmer Asia Africa SAmer Ocean Local Exact Pct [Context]
0 2945 2339 11977 7925 46 560 2094 17464 <----------- Totals
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 94 320 3226 2872 0 206 536 7254 3188 43% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KVIS.RF...L. 0 24 88 857 185 0 25 192 1371 826 60% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KVIS.RF...LD 0 32 95 875 60 0 84 21 1167 752 64% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,E1150D]
.IT-S.L.--F.SG.-IGFNDV.TKHDWSL.K-K.KV.S.RF...L. 0 17 48 312 552 0 13 56 998 388 38% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDVTTKHDWSL.K-K.KV.S.RF..LL. 0 29 64 454 59 0 0 63 669 357 53% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWSL.K-KEKV.S.RF..LL. 0 22 14 345 36 0 0 67 484 366 75% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.IT-S.L.--F.SG.-IGFNDVTTKHDWSL.K-K.KV.S.RF...L. 0 29 66 208 41 17 1 29 391 178 45% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDVTTKHDWS..K-K.KV.S.RF...L. 0 6 28 224 60 10 3 23 354 188 53% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.LS--F.SG.-IGFNDVTTKHDWS..K-K.KV.S.RF.S.L. 0 4 7 267 9 0 0 2 289 161 55% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,A1087S,P1143L]
.IT-S.L.--F.SG.-IGFNDVTTKHDWSL.K-K.KV.S.RFR.LL. 0 5 16 159 27 0 0 25 232 80 34% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWSL.K-K.KV.S.RF..LL. 0 7 22 114 27 0 0 17 187 92 49% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDW..VK-K.KV.S.R...... 0 0 1 7 148 0 0 3 159 87 54% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,N460K,A475V,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,Q954H,N969K]
.IT-SFL.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 6 23 100 0 1 20 150 54 36% [T19I,R21T,L24-,P25-,P26-,A27S,S31F,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.LS--F.SG.-IGFNDVTTKHDWSL.K-K.KV.S.RF.S.L. 0 3 18 120 6 0 0 1 148 81 54% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,A1087S,P1143L]
.IT-S.L.--F.SG.-IGFNDVTTKHDWS..K-K.KVIS.RF...L. 0 1 1 142 2 0 0 0 146 61 41% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWSL.K-K.KVIS.RF...L. 0 6 40 21 12 0 0 61 140 82 58% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDW...K-K.KV.S.RF...L. 0 3 8 12 87 0 0 9 119 58 48% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.I.-S......Q..E..E....T..P..FL...A......H...... 0 0 1 5 107 0 2 2 117 30 25% [Q14K,T19I,L24-,P25-,P26-,A27S,Q52H,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445P,G446S,L455F,F456L,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,D614G,H655Y,N679K,P681H,N764K,D796Y,Q954H,N969K]
......L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 89 3 4 0 0 0 96 66 68% [S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S-L.--F.SGH-IGFNDVTTKHDWSL.K-K.KV.S.RF...L. 0 1 3 72 5 0 0 6 87 41 47% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDW...K-K.KV.S.R...... 0 0 0 2 77 0 0 4 83 55 66% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,Q954H,N969K]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.SFRF...L. 0 0 2 10 59 0 1 10 82 26 31% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IEFNDVTTKHDWS..K-K.KVIS.RF...L. 0 2 5 67 1 0 0 5 80 64 80% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213E,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.-F...L. 0 0 1 34 14 0 13 9 71 7 9% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681-,+683W,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SGH-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 1 0 50 9 0 0 0 60 25 41% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S-L.--FQSG.-IGFNDVTTKHDWSL.K-K.KV.S.RF..LL. 0 1 2 52 1 0 0 2 58 15 25% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,H146Q,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.IT-S.L.--F.SG...GFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 5 47 0 0 0 0 52 34 65% [T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWSL.K-K.KV.S.RFR.LL. 0 3 3 33 7 0 0 3 49 30 61% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.IT-S.L.--F.SG.-IGFNDVTTKHDWSV.K-K.KV.S.RF...L. 0 2 6 26 6 0 1 7 48 29 60% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456V,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.LS--F.SG.-IGFNDVTTKHDWS..K-K.KV.S.RF...L. 0 0 9 27 4 0 0 2 42 19 45% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKPDWSL.K-K.KV.S.RF...L. 0 0 7 23 0 0 0 9 39 21 53% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWSL.K-K.KV.SFRF...L. 0 0 0 32 5 0 0 2 39 25 64% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT.-.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 0 10 27 0 0 1 38 18 47% [+16MPLF,T19I,R21T,P25-,P26-,A27-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--FQSG.-IGFNDV.TKHDWS..K-K.KVIS.RF...L. 0 0 0 37 0 0 0 0 37 27 72% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,H146Q,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.I--S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 1 1 28 4 0 2 1 37 21 56% [+16MPLF,T19I,R21-,+22N,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.I.-S......Q..E..E....T..P.......A......H...... 0 14 10 9 2 0 0 0 35 3 8% [T19I,L24-,P25-,P26-,A27S,K77R,V83A,G142D,Y144X,H146Q,N148T,Q183E,N185X,F186X,V213E,D253G,G339H,R346T,L368I,S371F,S373P,+374F,T376-,D405N,R408S,K417N,N440K,V445P,G446S,N460K,S477N,E484A,F486P,F490S,Q498R,N501Y,Y505H,P521S,D614G,H655Y,N679K,P681H,N764K,D796Y,Q954H,N969K]
.IT-S.L.--F.SG.-IGFNDV.T.HDWS..K-K.KV.S.RF...L. 0 0 4 22 9 0 0 0 35 20 57% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWSL.K-K.KVIS.RF...LD 0 25 2 5 1 0 0 0 33 20 60% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,E1150D]
.IT-S.L.--F.SGH-IGFNDV.TKHDWS..K-K.KVIS.RF...L. 0 6 0 24 1 0 0 2 33 13 39% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.I.-S......Q..E..E....T..PD.FL...A......H...... 0 0 0 19 14 0 0 0 33 14 42% [T19I,L24-,P25-,P26-,A27S,Q52H,V83A,G142D,Y144-,H146Q,Q183E,V213E,+214YRR,G252V,G339H,R346T,L368I,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445P,G446S,N450D,L455F,F456L,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,D614G,H655Y,N679K,P681H,S704L,N764K,D796Y,Q954H,N969K]
.IT-S...--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 16 3 13 0 0 0 32 15 46% [T19I,R21T,L24-,P25-,P26-,A27S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDVITKHDWSL.K-K.KV.S.RF...L. 0 0 25 3 2 0 1 1 32 29 90% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346I,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S-.F...L. 0 0 0 11 17 0 0 2 30 16 53% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680-,+683R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.LL--F.SG.-IGFNDVTTKHDWSL.K-K.KV.S.RF..LL. 0 0 2 22 4 0 0 1 29 16 55% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,F59L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L,K1266R]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K..V.S.RF...L. 0 0 0 24 3 0 0 0 27 14 51% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.HF...L. 0 0 1 11 12 0 2 0 26 10 38% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681H,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S-L.--F.SG.-IGFNDVTTKHDWS..K-K.KV.S.RF...L. 0 2 2 12 1 1 5 2 25 12 48% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
..--S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 2 7 12 0 0 4 25 4 16% [+16MPLF,R21-,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F-SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 3 14 6 0 0 1 24 12 50% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF..LL. 0 0 0 12 9 0 0 3 24 12 50% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.SYRF...L. 0 0 0 7 5 0 0 12 24 18 75% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680Y,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDW.V.K-K.KV.S.RF...L. 0 1 0 10 13 0 0 0 24 13 54% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,F456V,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF..... 0 5 0 0 3 0 14 0 22 9 40% [T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K]
.IT-S.LS--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 0 0 20 0 1 0 21 11 52% [T19I,R21T,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KVIS.-F...LD 0 0 2 5 0 0 14 0 21 2 9% [T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681-,+683W,N764K,D796Y,S939F,Q954H,N969K,P1143L,E1150D]
......L.--F.SG.-IGFNDVTTKHDWS..K-K.KV.S.RF...L. 0 0 20 0 0 0 0 0 20 8 40% [S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDVTTKHDWSL.K-K.KVIS.RF...L. 0 0 0 4 0 0 0 15 19 11 57% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F-SG.-IGFNDVTTKHDWSL.K-K.KV.S.RF..LL. 0 0 0 15 1 0 0 2 18 12 66% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.IT-S-L.--F.SG.-IGFNDVTTKHDWSL.K-K.KV.S.RFR.LL. 0 0 0 11 1 0 0 6 18 13 72% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.IT-S.L.--F.SG...GFNDV.TKHDWS..K-K.KVIS.RF...L. 0 0 0 17 1 0 0 0 18 17 94% [T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--..SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 0 17 0 0 0 0 17 9 52% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,T961X,L962X,V963X,N969K,P1143L]
.IT-SFL.--F.SG.-IGFNDVTTKHDWSL.K-K.KV.S.RF..LL. 0 2 1 12 0 0 0 1 16 4 25% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31F,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.IT-S.L.--F.SG.-IGFNDVITKHDWS..K-K.KV.S.RF...L. 0 0 0 12 3 0 1 0 16 9 56% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346I,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...F. 0 1 2 4 9 0 0 0 16 8 50% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143F]
.IT-SFL.--F.SG.-IGFNDVTTKHDWSL.K-K.KV.S.RF...L. 0 2 1 1 12 0 0 0 16 6 37% [T19I,R21T,L24-,P25-,P26-,A27S,S31F,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDVSTKHDWS..K-K.KV.S.RF...L. 0 0 1 7 3 0 0 4 15 3 20% [L5X,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,C136X,G142X,Y144-,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,W258X,A264D,F318X,V320X,I332V,G339H,R346S,K356T,V367X,S371F,S373P,S375F,T376A,R403K,D405N,R408S,Q414X,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,S943X,D950X,Q954H,N969K,G1124X,P1143L,W1214X]
.I.-S......Q..E..E....T..P..FLV..A......H...... 0 1 2 0 10 0 1 0 14 3 21% [T19I,L24-,P25-,P26-,A27S,Q52H,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445P,G446S,L455F,F456L,N460K,A475V,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,D614G,H655Y,N679K,P681H,N764K,D796Y,Q954H,N969K]
.IT-S.L.--F.SG.-IGFNDV.TKHDW...K-K.KV.SFRF...L. 0 0 0 0 13 0 0 0 13 9 69% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.F-F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 0 5 6 0 1 0 12 6 50% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69F,V70-,S71-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.I.-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 4 1 7 0 0 0 12 7 58% [T19I,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-SPL.--F.SG.-IGFNDVTTKHDWS..K-K.KV.S.RF...L. 0 0 0 10 0 0 1 0 11 6 54% [T19I,R21T,L24-,P25-,P26-,A27S,S31P,S50L,F58Y,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.I--S.L.--F.SG.-IGFNDVTTKHDWS..K-K.KV.S.RF...L. 0 0 0 11 0 0 0 0 11 3 27% [+16MPLF,T19I,R21-,+22N,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,P174S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.G--FNDV.TKHDWS..K-K.KV.S.RF...L. 0 1 0 4 6 0 0 0 11 5 45% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,+209V,N211G,L212-,V213-,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWS..K-K.KVIS.-F...L. 0 1 0 3 5 0 2 0 11 2 18% [T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681-,+683Q,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWSL.K-K.KVIS.RFR.LL. 0 0 0 6 2 0 0 2 10 4 40% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.IT-S.L.--F.SG...GFNDV.TKHDWS..K-K.KVIS.RF...LD 0 0 2 8 0 0 0 0 10 10 100% [T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,E1150D]
.IT-S.L.--F.SG.-IGFNDV.TKHDW...K-K.KVIS.R...... 0 0 0 1 9 0 0 0 10 9 90% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,Q954H,N969K]
.IT-SPL.--F.SG.-IGFNDV.TKHDWS..K-K.KV.S.RF...L. 0 0 0 8 1 0 0 1 10 2 20% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,R273S,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT-S.L.F-F.SG.-IGFNDVTTKHDWSL.K-K.KV.S.RF...L. 0 4 5 1 0 0 0 0 10 4 40% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69F,V70-,S71-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.I--S.L.--F.SG.-IGFNDV.TKHDWSL.K-K.KV.S.RF...L. 0 0 0 0 1 0 0 9 10 6 60% [+16MPLF,T19I,R21-,+22N,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
......LS--F.SG.-IGFNDVTTKHDWSL.K-K.KV.S.RF.S.L. 0 0 10 0 0 0 0 0 10 7 70% [S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,A1087S,P1143L]
.IT-S.L.--F.SG.-IGFNDV.TKHDWSL.K-K.KVIS.RF..LL. 0 0 1 8 1 0 0 0 10 8 80% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
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