COVID-19 Viral Genome Analysis Pipeline
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Frequency Changes in Common Forms
Last update: Jan 14, 2026
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SPIKE sequences: Exhaustive list of Last 60 days, Global, Do not break out by lineage
Compute mutations relative to XBB.1.5 baseline sequence
As new lineages emerge, there are often many sequences with many ambiguous base calls. Our pipeline filters out such sequences, and as a consequence we undercount the number of sequences in GISAID that have been specified as members of related Pango lineages. Our strategy, however, enables us to use strictly high quality sequences to identify and track the common forms in emerging lineages.
COMMON FORMS CHANGES FOR SPIKE WITH A GIVEN PANGO LINEAGE DESIGNATION
For each lineage, we show the most common forms of SPIKE, and we show the forms that are most significantly increasing or decreasing. Also shown is the Hamming distance (HD) between each form and the most common form in that lineage. Deletions relative to the baseline reference strain are indicated with a dash (e.g. the two amino acid deletion at positions 156-157 is indicated with 'E156-,F157-'), and insertions are denoted by a plus sign (e.g. an extra T at position 143 is written '+143T'). Abs Differences in later vs early fractions, expressed as percent. Relative Differences range between -100% and +100%, using formula: rel = 100*(later-early)/max(later,early) percent, applied to the early and later fractions. The p-value associated with increase or decrease is computed by Fisher's exact test, and is meant to be used only as a rough guide to the significance of the change. Since the computation is based on assumptions (such as independent and unbiased sampling) that may not hold in practice, the p-value should not be taken too literally. The first line of each lineage section indicates counts for the full lineage relative to all the sequences. 'Lineage Count' in this first line is actually the full sequence count. 'Form Count' in this first line is actually the full lineage count, and 'Form Pct' refers to lineage count relative to full sequence set.
We show all the forms.
[Note: Mutation strings are relative to baseline XBB.1.5].
This output is based on 4826 sequences sampled from 2025-11-07 to 2026-01-06
This total interval is split into two sub-intervals.
Total: 2025-11-07 to 2026-01-06 (4826)
Early: 2025-11-07 to 2025-11-24 (2372)
Later: 2025-11-25 to 2026-01-06 (2454)
Baseline XBB.1.5: [T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,D614G,H655Y,N679K,P681H,N764K,D796Y,Q954H,N969K]
Pango Lineage Form Form Counts Fractions Differences Lineage Count Count Pct Early/Later Early/Later Abs Relative pval HD [Form as mutation string] N/A 4826 812 16.8% 483/329 0.20363/0.13407 -6.96% -34.2% <1e-10 0 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] (consensus) N/A 4826 228 4.7% 96/132 0.04047/0.05379 +1.33% +24.8% 3e-2 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 184 3.8% 120/64 0.05059/0.02608 -2.45% -48.4% 8e-6 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 172 3.6% 79/93 0.03331/0.03790 +0.46% +12.1% 4e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 157 3.3% 64/93 0.02698/0.03790 +1.09% +28.8% 3e-2 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 123 2.5% 35/88 0.01476/0.03586 +2.11% +58.9% 3e-6 86 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 90 1.9% 44/46 0.01855/0.01874 +0.02% +1.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 88 1.8% 27/61 0.01138/0.02486 +1.35% +54.2% 5e-4 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 88 1.8% 46/42 0.01939/0.01711 -0.23% -11.7% 6e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 85 1.8% 63/22 0.02656/0.00896 -1.76% -66.2% 3e-6 4 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 77 1.6% 29/48 0.01223/0.01956 +0.73% +37.5% 5e-2 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 64 1.3% 30/34 0.01265/0.01385 +0.12% +8.7% 8e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 52 1.1% 26/26 0.01096/0.01059 -0.04% -3.3% 1e+0 14 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 50 1.0% 14/36 0.00590/0.01467 +0.88% +59.8% 3e-3 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 38 0.8% 9/29 0.00379/0.01182 +0.80% +67.9% 2e-3 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 33 0.7% 17/16 0.00717/0.00652 -0.06% -9.0% 9e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 33 0.7% 17/16 0.00717/0.00652 -0.06% -9.0% 9e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,G946R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 33 0.7% 14/19 0.00590/0.00774 +0.18% +23.8% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 30 0.6% 18/12 0.00759/0.00489 -0.27% -35.6% 3e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 28 0.6% 18/10 0.00759/0.00407 -0.35% -46.3% 1e-1 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 4826 27 0.6% 17/10 0.00717/0.00407 -0.31% -43.1% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 27 0.6% 18/9 0.00759/0.00367 -0.39% -51.7% 8e-2 7 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 26 0.5% 3/23 0.00126/0.00937 +0.81% +86.5% 9e-5 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 25 0.5% 16/9 0.00675/0.00367 -0.31% -45.6% 2e-1 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 24 0.5% 23/1 0.00970/0.00041 -0.93% -95.8% 1e-6 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 4826 22 0.5% 13/9 0.00548/0.00367 -0.18% -33.1% 4e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 22 0.5% 13/9 0.00548/0.00367 -0.18% -33.1% 4e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 22 0.5% 16/6 0.00675/0.00244 -0.43% -63.8% 3e-2 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 21 0.4% 5/16 0.00211/0.00652 +0.44% +67.7% 3e-2 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 21 0.4% 7/14 0.00295/0.00570 +0.28% +48.3% 2e-1 16 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 21 0.4% 11/10 0.00464/0.00407 -0.06% -12.1% 8e-1 10 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 18 0.4% 11/7 0.00464/0.00285 -0.18% -38.5% 4e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 18 0.4% 11/7 0.00464/0.00285 -0.18% -38.5% 4e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 18 0.4% 6/12 0.00253/0.00489 +0.24% +48.3% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,M731I,S939F,P1143L,I1172V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 18 0.4% 5/13 0.00211/0.00530 +0.32% +60.2% 1e-1 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153V,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 17 0.4% 7/10 0.00295/0.00407 +0.11% +27.6% 6e-1 7 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 16 0.3% 15/1 0.00632/0.00041 -0.59% -93.6% 2e-4 1 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 16 0.3% 9/7 0.00379/0.00285 -0.09% -24.8% 6e-1 11 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 15 0.3% 7/8 0.00295/0.00326 +0.03% +9.5% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 15 0.3% 15/0 0.00632/0.00000 -0.63% -100.0% 2e-5 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,G798S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 14 0.3% 12/2 0.00506/0.00081 -0.42% -83.9% 6e-3 16 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 14 0.3% 2/12 0.00084/0.00489 +0.40% +82.8% 1e-2 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I326V,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 14 0.3% 9/5 0.00379/0.00204 -0.18% -46.3% 3e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,E1202Q]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 14 0.3% 1/13 0.00042/0.00530 +0.49% +92.0% 2e-3 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,L179F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641T,P681R,R683L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 14 0.3% 2/12 0.00084/0.00489 +0.40% +82.8% 1e-2 86 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,E583D,H625R,N641K,V642G,E654K,N679R,P681R,A688D,S704L,K795T,A852K,S939F,P1162R,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K,P681H] N/A 4826 13 0.3% 7/6 0.00295/0.00244 -0.05% -17.1% 8e-1 11 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 11 0.2% 6/5 0.00253/0.00204 -0.05% -19.5% 8e-1 7 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,G946R,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 11 0.2% 5/6 0.00211/0.00244 +0.03% +13.8% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,V62I,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 11 0.2% 0/11 0.00000/0.00448 +0.45% +100.0% 1e-3 88 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,S98F,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,Q173H,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 11 0.2% 2/9 0.00084/0.00367 +0.28% +77.0% 7e-2 86 +[P9L,R21T,P26F,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 10 0.2% 4/6 0.00169/0.00244 +0.08% +31.0% 8e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 10 0.2% 4/6 0.00169/0.00244 +0.08% +31.0% 8e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 10 0.2% 2/8 0.00084/0.00326 +0.24% +74.1% 1e-1 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478V,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 10 0.2% 2/8 0.00084/0.00326 +0.24% +74.1% 1e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,E1182D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 10 0.2% 4/6 0.00169/0.00244 +0.08% +31.0% 8e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,Q1208H]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 9 0.2% 6/3 0.00253/0.00122 -0.13% -51.7% 3e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 9 0.2% 2/7 0.00084/0.00285 +0.20% +70.4% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 4826 9 0.2% 2/7 0.00084/0.00285 +0.20% +70.4% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 8 0.2% 1/7 0.00042/0.00285 +0.24% +85.2% 7e-2 10 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 4826 8 0.2% 1/7 0.00042/0.00285 +0.24% +85.2% 7e-2 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A263S,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 8 0.2% 0/8 0.00000/0.00326 +0.33% +100.0% 8e-3 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1228L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 8 0.2% 5/3 0.00211/0.00122 -0.09% -42.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,I1114T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 8 0.2% 6/2 0.00253/0.00081 -0.17% -67.8% 2e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 7 0.1% 2/5 0.00084/0.00204 +0.12% +58.6% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1146G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 7 0.1% 0/7 0.00000/0.00285 +0.29% +100.0% 2e-2 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,G181V,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 7 0.1% 3/4 0.00126/0.00163 +0.04% +22.4% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 7 0.1% 1/6 0.00042/0.00244 +0.20% +82.8% 1e-1 13 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 7 0.1% 7/0 0.00295/0.00000 -0.30% -100.0% 7e-3 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 7 0.1% 5/2 0.00211/0.00081 -0.13% -61.3% 3e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,H146-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 7 0.1% 0/7 0.00000/0.00285 +0.29% +100.0% 2e-2 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445Y,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 7 0.1% 3/4 0.00126/0.00163 +0.04% +22.4% 1e+0 16 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K147I,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621-,V622-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 6 0.1% 1/5 0.00042/0.00204 +0.16% +79.3% 2e-1 9 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 6 0.1% 4/2 0.00169/0.00081 -0.09% -51.7% 4e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 6 0.1% 0/6 0.00000/0.00244 +0.24% +100.0% 3e-2 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,V308L,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 6 0.1% 2/4 0.00084/0.00163 +0.08% +48.3% 7e-1 11 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 6 0.1% 2/4 0.00084/0.00163 +0.08% +48.3% 7e-1 10 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 6 0.1% 3/3 0.00126/0.00122 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 6 0.1% 3/3 0.00126/0.00122 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 6 0.1% 4/2 0.00169/0.00081 -0.09% -51.7% 4e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A684V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 6 0.1% 3/3 0.00126/0.00122 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 4826 6 0.1% 3/3 0.00126/0.00122 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,W152R,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,R246G,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 6 0.1% 3/3 0.00126/0.00122 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 6 0.1% 0/6 0.00000/0.00244 +0.24% +100.0% 3e-2 6 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,G946R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 6 0.1% 2/4 0.00084/0.00163 +0.08% +48.3% 7e-1 11 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 6 0.1% 6/0 0.00253/0.00000 -0.25% -100.0% 1e-2 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 6 0.1% 6/0 0.00253/0.00000 -0.25% -100.0% 1e-2 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,T1117I,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 6 0.1% 6/0 0.00253/0.00000 -0.25% -100.0% 1e-2 11 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 6 0.1% 0/6 0.00000/0.00244 +0.24% +100.0% 3e-2 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,T478K,E484A,F490S,P681H] N/A 4826 5 0.1% 0/5 0.00000/0.00204 +0.20% +100.0% 6e-2 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 5 0.1% 0/5 0.00000/0.00204 +0.20% +100.0% 6e-2 11 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 5 0.1% 2/3 0.00084/0.00122 +0.04% +31.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 5 0.1% 3/2 0.00126/0.00081 -0.04% -35.6% 7e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I326V,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 5 0.1% 0/5 0.00000/0.00204 +0.20% +100.0% 6e-2 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 5 0.1% 3/2 0.00126/0.00081 -0.04% -35.6% 7e-1 17 +[N17M,+17P,T19F,T20N,R21F,+21I,Q23T,L24N,P25Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,+344S,R346-,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 4826 5 0.1% 2/3 0.00084/0.00122 +0.04% +31.0% 1e+0 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 5 0.1% 0/5 0.00000/0.00204 +0.20% +100.0% 6e-2 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,L176F,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 5 0.1% 5/0 0.00211/0.00000 -0.21% -100.0% 3e-2 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,V171I,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 5 0.1% 3/2 0.00126/0.00081 -0.04% -35.6% 7e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,I569V,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 5 0.1% 5/0 0.00211/0.00000 -0.21% -100.0% 3e-2 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 4826 5 0.1% 0/5 0.00000/0.00204 +0.20% +100.0% 6e-2 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 4 0.1% 2/2 0.00084/0.00081 -0.00% -3.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 4 0.1% 3/1 0.00126/0.00041 -0.09% -67.8% 4e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529R,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 2/2 0.00084/0.00081 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157L,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 2/2 0.00084/0.00081 -0.00% -3.3% 1e+0 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 4 0.1% 0/4 0.00000/0.00163 +0.16% +100.0% 1e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 3/1 0.00126/0.00041 -0.09% -67.8% 4e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157L,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,V227L,A243-,L244-,P251S,I326V,G339Y,A348P,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,E583D,H625R,N641K,V642G,E654K,N679R,P681R,A688D,S704L,K795T,A852K,S939F,P1162R,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 2/2 0.00084/0.00081 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,A67V,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 3/1 0.00126/0.00041 -0.09% -67.8% 4e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,K558N,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219D,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 4 0.1% 1/3 0.00042/0.00122 +0.08% +65.5% 6e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 4 0.1% 3/1 0.00126/0.00041 -0.09% -67.8% 4e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 2/2 0.00084/0.00081 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 4/0 0.00169/0.00000 -0.17% -100.0% 6e-2 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,S1170F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 4 0.1% 4/0 0.00169/0.00000 -0.17% -100.0% 6e-2 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,S98F,V127F,W152R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 4 0.1% 4/0 0.00169/0.00000 -0.17% -100.0% 6e-2 9 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 4 0.1% 2/2 0.00084/0.00081 -0.00% -3.3% 1e+0 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 4 0.1% 3/1 0.00126/0.00041 -0.09% -67.8% 4e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,T250A,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 11 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,Q677R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 8 +[R21T,T22N,S31P,S50L,S60P,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,L244S,H245N,P251L,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 3/0 0.00126/0.00000 -0.13% -100.0% 1e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A263S,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A1020S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258R,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 2/1 0.00084/0.00041 -0.04% -51.7% 6e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 3/0 0.00126/0.00000 -0.13% -100.0% 1e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 11 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445R,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 3 0.1% 2/1 0.00084/0.00041 -0.04% -51.7% 6e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,L922F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 2/1 0.00084/0.00041 -0.04% -51.7% 6e-1 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532S,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 12 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,R765L,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,G446T,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,G446S,E484A,F490S,N679K,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 13 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 14 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,P1143L,I1169V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 3 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,I670M,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 16 +[N17M,+17P,T19F,T20N,R21F,+21I,Q23T,L24N,P25Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A831V,S939F,P1143L]-[T19I,L24-,P25-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1176F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 3 0.1% 2/1 0.00084/0.00041 -0.04% -51.7% 6e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,I1114T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G257D,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E,A1222T]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 3 0.1% 2/1 0.00084/0.00041 -0.04% -51.7% 6e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F140V,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,W64R,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,S940F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642G,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S929T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,A522V,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,+938F,T941-,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L,V1228A]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,T573I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 3 0.1% 2/1 0.00084/0.00041 -0.04% -51.7% 6e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 3/0 0.00126/0.00000 -0.13% -100.0% 1e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 3/0 0.00126/0.00000 -0.13% -100.0% 1e-1 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 2/1 0.00084/0.00041 -0.04% -51.7% 6e-1 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,K300R,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V622A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 3/0 0.00126/0.00000 -0.13% -100.0% 1e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L,C1247S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 3 0.1% 2/1 0.00084/0.00041 -0.04% -51.7% 6e-1 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 2/1 0.00084/0.00041 -0.04% -51.7% 6e-1 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 3/0 0.00126/0.00000 -0.13% -100.0% 1e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 2/1 0.00084/0.00041 -0.04% -51.7% 6e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 8 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 0/3 0.00000/0.00122 +0.12% +100.0% 3e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,I358F,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,M740T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 3 0.1% 1/2 0.00042/0.00081 +0.04% +48.3% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,T500A,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,P217S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,I934V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N440R,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157L,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 19 +[R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L,V1176F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,H146-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,A522P,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,E702Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,T108S,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 16 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642G,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,A67V,H69-,V70-,V127F,M153I,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,Q218E,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,Q218H,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 3 +[+16MPLF,R21T,T22N,A27-,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A942S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,T95I,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S875A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 11 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A243S,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 12 +[+16MPLF,R21T,T22N,S31F,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,H146-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211T,L212G,V213-,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1189A]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 6 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,Q675H,P681R,S939F,A942T,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 3 +[+16MPLF,R21T,T22N,N30I,S31-,F32-,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547I,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,W152L,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,M177V,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,R273K,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16KPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,A243S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 17 +[N17M,+17P,T19F,T20N,R21F,+21I,Q23T,L24N,P25Q,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A942S,G946R,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 14 +[L5F,+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 10 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 10 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,T478R,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T274I,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S31P,S50L,W64L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1146G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 8 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 87 +[P9L,R21T,P26L,L54F,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 1 +[+16TPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,L54F,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L,L1224F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,K182N,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 87 +[F2L,P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S704A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F135L,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,L189F,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532S,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,G482-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V120F,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 11 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,N955H,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219D,H245N,A264D,I332V,K356T,P384S,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,A522V,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,I472V,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,V62F,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 15 +[+16MPLF,R21T,T22N,T33I,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,I1130L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,G75D,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1020S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157L,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,T827I,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,I624M,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,Y505H,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,L1197F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K417T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A942S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,G252D,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 8 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,K825R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,I692L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,T1231A]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 14 +[T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,G72E,V127F,K150I,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,I1114T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,C1250F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 12 +[R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 14 +[N17M,+17P,T19F,T20N,R21F,+21I,Q23T,L24N,P25Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,I1130M,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,D80Y,V127F,F157S,R158G,K182R,L189F,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S810L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,I1198V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253V,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 11 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,R765L,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31L,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,I1114T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,L176F,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1146N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,E1202Q]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S704L,S939F,P1143L,S1252F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,A123V,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 13 +[L5F,+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[V6F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,D936H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,N148T,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153K,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 19 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D936Y,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,G72R,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,I1169V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,I105V,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,Q613H,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 10 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,L189F,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,D796H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 12 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,E702K,S939F,K1086R,V1104L,P1143L,V1189A]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K417T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,Y505H,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,G72E,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,R683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,+209T,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,G1251V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96Y,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 21 +[R21T,L24S,P25T,P26Q,S31-,S50L,H69-,V70-,V127F,N137K,D138H,K150E,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,R765L,S939F,K1086R,V1104L,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 8 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,G946R,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 8 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1263L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 19 +[R21T,T22N,L24S,P25N,P26Q,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V635I,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,P384S,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,A67V,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V635A,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,V687I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,K77R,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143F,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,D111N,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I326V,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,E154V,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 0/2 0.00000/0.00081 +0.08% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,G946R,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 2/0 0.00084/0.00000 -0.08% -100.0% 2e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 2 0.0% 1/1 0.00042/0.00041 -0.00% -3.3% 1e+0 13 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,V687I,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,Q677R,N717S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,L176F,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,I569V,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H,Q954H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 9 +[R21T,T22N,S31P,S50L,S60P,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D985G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[+16CAF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 18 +[+16SLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,M153V,F157S,R158G,L176F,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,G1099D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A222S,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157L,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1260Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,Y145L,H146-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[R21T,T22N,S31P,S46A,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[S13T,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,A163V,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 9 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H,D796Y] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,I68T,H69-,V70-,V127F,N148T,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,Q677R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,W152R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,D1153G]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P812S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,A575S,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T791I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,S71F,S98F,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157P,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,N30I,S31-,F32-,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[V3G,+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,G257V,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,V642F,P681R,R683Q,I850V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,G946R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,G446S,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[L18F,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,G946R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[T20I,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,H146-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,N30K,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,E309Q,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16IPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96Y,I101T,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,A688V,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147N,S151N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31P,S50L,W64R,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 19 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,Y145P,H146-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[R21T,T22N,S31P,S50L,A67V,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,A942S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,I934V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,N1187S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 20 +[P9L,R21T,P26L,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N641K,V642G,E654K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[R21T,P26L,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 16 +[P9L,R21T,P26L,S31P,S50L,H69-,V70-,V127F,F157S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 33 +[P9L,R21T,P26L,S50L,H69-,V70-,T95I,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445A,N450D,L452W,L455S,F456L,V483-,E484K,E554K,A570V,P621S,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,T478K,E484A,F486P,F490S,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K417T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 18 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,E702Q,S939F,P1143L,I1179V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A701V,P809S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,C1247F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,Q1201H]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S254F,A264D,R273T,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 16 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211I,+211G,V213-,R214-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,N148T,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,E654V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335S,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A852S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,S943N,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,I794V,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 11 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S31P,T33A,S50L,H69S,S71-,G72-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,R78M,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,P561H,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q675K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 18 +[+16MPLF,R21T,S31-,S50L,I68-,H69-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678-,+679K,P681R,A688V,A899S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,T874I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,I1130T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335S,K356T,T376S,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T376A,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,T95I,V127F,F157S,R158G,K182R,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,T95I,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T638K,S680P,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,E1092G,P1143L,D1146G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 9 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,A688V,S704L,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677R,P681R,S939F,P1143L,D1168G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V622A,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,Q173E,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,N121S,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 9 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S640Y,N641-,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V83I,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,G446S,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,G75V,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,L441F,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,G181E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 77 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,Y248H,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 17 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,T376N,R403K,N440R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L,V1176F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,N440K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 10 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,D253H,A264D,I332V,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,G639S,P681R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,N657H,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,N148Y,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,G181A,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,A647V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251S,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,H1058Y,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 18 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H,Q954H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 24 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,I1114T,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A263S,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,M177I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[S31P,S50L,H69-,V70-,T95I,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,A958S,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 24 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,I670M,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,S373P,T376A,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376S,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T376A,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,G339H,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 23 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[S31P,S50L,H69-,V70-,V127F,S151I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[S31P,S50L,H69-,V70-,V127F,K150I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 23 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[S31P,S50L,H69-,V70-,V127F,E154Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,G842S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,V62I,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[V6A,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,S943G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,Y28H,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157L,R158G,K182R,R190S,N211-,L212I,V213G,L216F,Q218L,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,D1199Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,E868D,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I818V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642G,P681R,G798C,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,S151G,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,N450D,L452K,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q675K,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S691F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A771G,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486S,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,N148D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,L117I,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547I,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,F1121L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[N17M,+17P,T19F,T20N,R21L,T22I,Q23I,L24T,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,G1099D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,K1191M]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,P384S,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,E156V,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,A623S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F135L,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,T259I,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,G482S,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,A163V,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,W64R,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A783V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,Q1071R,P1143L,D1146G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[L8F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 88 +[P9L,R21-,+22I,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,A93S,V127F,N148S,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,K77R,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,D796H,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K,D796Y] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,T95I,V127F,F157S,R158G,K182R,L189F,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,E154V,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,H1101D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,A243S,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 9 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,Y144N,Y145-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,A243-,L244-,P251S,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T676A,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,I68-,H69-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,G482S,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 85 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,A706V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,N532S,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 88 +[L5F,P9L,R21T,P26L,A67V,H69-,V70-,G75S,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K147I,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A942S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,D178N,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T376A,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AL,+215TD,V227L,A243-,L244-,P251S,I326V,G339Y,A348P,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,E583D,H625R,N641K,V642G,E654K,N679R,P681R,A688D,S704L,K795T,A852K,S939F,P1162R,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S698L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,L1265P]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,L176F,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,L938F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[S12C,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,P809S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,G946K,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,Q677R,A688V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,E1072Q,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 25 +[N17M,+17P,+18FNFI,R21-,S31-,S50L,N61D,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,Q677L,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,G482S,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[L18I,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 10 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,Y145N,H146-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153V,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,T998I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158E,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1094I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q675R,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,N1108K,M1237V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,T76I,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,L727V,+938F,T941-,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16LPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1228I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,N679M,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 10 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642G,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,G75V,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,V267L,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257R,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,A123V,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,S46L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A344T,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,I1221V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147R,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,D796H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[L5F,+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,V62L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,E156D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,N703Y,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211K,L212G,V213-,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,I472V,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,G142Y,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L,Y1272H]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,E654K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,E309Q,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,G1251V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K417T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,K986R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,D1153G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,Y248H,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T827S,S939F,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,P1263L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 58 +[L5F,T51N,H69-,V70-,T76I,H146K,F157L,T385I,F490P,L517F,I569T,T572I,T618K,D796H,D843A,T941S,S1003I,V1060I]-[Y144-,H146Q,F490S,D796Y] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,S151I,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,K786R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S256-,G257-,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31P,S50L,A67V,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 16 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,H146-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,V227L,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,S940F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16KPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,H146-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,L849I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,T961A,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 19 +[R21T,T22N,T33I,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,I1130L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 9 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,A1174V,L1265F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[L5F,P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,+209T,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,T208M,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,N148Y,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L,K1181R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481R,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 88 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,A522P,K529N,E554D,E583D,H625R,N641K,V642G,E654K,N679R,P681R,A688D,S704L,K795T,A852K,S939F,D1084Y,P1162R,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182I,R190S,N211-,L212I,V213G,L216F,H245N,G257V,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[R21T,T22N,A27-,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 83 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,T500A,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,G1124V,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478Q,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,D1153G,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,H49Y,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642A,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157L,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642A,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444T,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,R78K,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,A626V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L,D1260A]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31L,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,H519Y,E554K,A570V,P621S,I624M,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,Y505H,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,K1191N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[F2L,+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A222V,H245N,A264D,L270I,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,R765L,A852T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,T73I,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1078V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P809S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,M153V,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,T73N,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 18 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R765L,S939F,P1143L,V1228L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 18 +[R21T,T22N,S50L,T51A,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,W258S,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,D88H,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16KPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642G,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPPF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,K1181E]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G257S,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,I670M,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,T236S,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641Y,P681R,D936Y,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,I434T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,G1251V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,T33I,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[V6I,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,Q954H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,N280K,E281-,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T274I,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,I794V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V367I,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,G257S,W258L,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,F1095L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T676N,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V90F,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,P139L,K150E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,L922F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153V,F157S,R158G,K182R,R190S,N211-,L212I,V213G,D215G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487G,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,K278N,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,I569V,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,H655Y,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,N969K] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,F157S,R158G,M177I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 9 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153V,F157S,R158G,K182R,R190S,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,G946R,P1143L,A1174V]-[V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,L368I,S477N,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[+16MPLF,R21T,T22N,S31P,S50L,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,A958S,P1143L]-[V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,D614G,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G261C,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[+16MPLF,R21T,T22N,S31P,S50L,W64R,H69-,V70-,V127F,K182R,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H,N764K,N969K] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,N1023Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529N,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,Q1180K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,D88G,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,E154Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,E583D,H625R,N641K,V642G,E654K,N679R,P681R,A688D,S704L,K795T,A852K,S939F,D1084Y,P1162R,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,K558N,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,T51A,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,R346K,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[F2L,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1162T]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,G181V,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V622F,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,H1088Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A263S,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,G482S,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,R78S,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,K97N,V127F,F157S,R158G,K182R,R190S,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,S373P,T376A,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,G594S,P621S,P681R,+938F,T941-,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,I670M,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,S98F,V127F,F157S,R158G,G184S,N211I,+211G,V213-,R214-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,N556K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,M1233I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[R21T,T22N,S31P,S50L,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,V826L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,T791I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[V6L,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 10 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481I,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[V6L,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,T376A,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,S940F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,T376A,V445P,G446S,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[V6L,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[V6L,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,H69-,V70-,V127F,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,V534I,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680-,A684R,S939F,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,T470I,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,D253G,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529Q,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,E224Q,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,G946R,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,V1137I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,H655F,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,H655Y,N679K] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,I788T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127L,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,Q183H,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A222S,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,G946R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,A1020V,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,A575S,P621S,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211I,L212R,V213-,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,T791I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,I670M,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,R78K,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,L1265I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,K77R,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,V320F,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,Q183R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,Q677R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,H625R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,T95I,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,T95I,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1184G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A871V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,L118F,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,I794S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 86 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,H245Y,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,A653V,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 88 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,V227L,A243-,L244-,P251S,I326V,G339Y,A348P,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,E583D,H625R,N641K,V642G,E654K,N679R,P681R,A688D,S704L,K795T,A852K,S939F,P1162R,D1184E,C1247F]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,T500A,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,D178N,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,W152L,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,W152R,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S659L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483R,E484-,N487D,Q493E,E554K,A570V,T572I,P621S,I670V,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,+344S,R346-,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A942T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,A829T,S939F,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G261S,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,W152R,F157S,R158G,K182R,N185D,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,A942S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,N122D,V127F,W152L,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683Q,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,P812T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N751Y,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,A27-,S31P,S50L,H69-,V70-,V127F,K150E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,Y144N,Y145-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 11 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,R683L,T791A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,T547I,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[Q14H,+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153V,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,P217T,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16TPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,E471V,A475S,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,A688V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,R683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D979E,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,A575S,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,P812L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,V642F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 18 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,N148I,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,K814R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,L270F,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,T961M,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 10 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 26 +[N17M,+17P,T19F,T20N,R21L,T22I,Q23I,L24T,P25N,P26Q,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K150N,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,D936Y,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,N148D,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,R683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,C1243F,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,T376A,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S704L,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,T250I,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,H146-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[+16MPLF,R21-,Q23N,L24R,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[L24-,V83A,H146Q,Q183E,V213E,G252V,L368I,S371F,S373P,S375F,T376A,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,P39L,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,P793S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S31P,S50L,A67V,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,S680F,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A684V,A688S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A684V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[+16F,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[V16A,+16ALF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,D80Y,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 16 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376S,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,R765L,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T376A,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,Y144H,Y145-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[R21T,T22N,S31P,L48F,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,A344S,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,I794T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A899S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,N30I,S31-,F32-,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,A344S,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483R,E484-,Q493E,T547K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,D405N,R408S,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,F58L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,S112L,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,E780A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S45A,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S640Y,N641-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A684T,D796H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[+16MPLF,R21T,T22N,S31P,V47F,S50L,H69S,S71-,G72-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 16 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N440R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L,V1176F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,N440K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,F186L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1078V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 16 +[L5F,+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,G181E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,D138Y,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F175L,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,M177I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 9 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F175L,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,G184S,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,S1252P]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,E1150V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,N960D,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483K,E484S,G485P,F486D,N487-,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258R,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,G482-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,I1172V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,D745G,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,N148D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,R683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I805V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,+373L,S375A,T376-,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,T376A,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q675K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,F338L,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,N532S,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 10 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,I1114V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445R,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,G946R,P1143L,Q1201K,A1226T]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,W152R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 19 +[R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,E309D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,E661D,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,F59S,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V367I,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251L,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L,V1230A]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 11 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[S31P,S50L,L54F,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258R,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 11 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219D,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 23 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,Y248H,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V622I,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 24 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,E471Q,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N658D,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,P217S,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,G75V,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,L981F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,K558N,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,D574N,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,K77R,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A262T,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 11 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,A522P,E554K,A570V,P621S,S680F,P681R,I909V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S256-,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,+938F,T941-,G1085R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,L176F,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96A,V127F,K147E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 19 +[R21T,S31-,S50L,H69-,V70-,V127F,K147E,F157S,R158G,F186L,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,Q1071R,K1086R,V1104L,P1143L,L1244P]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,I101V,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 9 +[L8F,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,T547I,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,G476S,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,T791A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 11 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G257-,W258-,T259-,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258R,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,T33I,S50L,F59S,V62I,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P631S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 9 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[+16MPLV,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S46L,S50L,H69-,V70-,V127F,K147E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,L754F,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,T1009I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,G446T,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 10 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,D178N,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,T51A,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,V534I,E554K,A570V,P621S,P681R,S939F,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182I,R190S,N211-,L212I,V213G,L216F,H245N,A264D,R273K,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N440R,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153T,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,L176F,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,S155N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 89 +[L5F,P9L,R21T,P26L,A67V,H69-,V70-,T95I,S98F,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,Q173H,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,T588I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 19 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,C1235F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346A,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,H625R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,P337S,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,G1219S,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157L,R158G,G184S,F186L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V382A,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A688P,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,L189F,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,C1250Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,N137T,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150R,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,P139S,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A1078S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,V1228A]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182T,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554N,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182T,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,V534I,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157L,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A260S,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,T719I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 18 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157L,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 19 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,D178N,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A871V,S939F,A1078S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1146G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,L922M,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,V1008L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,Y269C,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,E1202Q,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 9 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,V308L,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,A626S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[N17M,+17P,T19F,T20N,R21L,T22I,Q23I,L24T,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,T478R,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 10 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,Y505H,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,G252S,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Y505H,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,D228E,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,V159I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,K1191N]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A243V,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,Q787L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,Q804K,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,A123V,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,Y28H,S50L,F59S,H69-,V70-,V127F,E154Q,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S810L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A684V,S939F,A958S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,Y269H,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,V642G,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[+16TPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,T500S,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 7 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,A67S,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L,V1164I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,V289A,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A871S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,E702Q,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,E340Q,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481R,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A1070V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,Q218H,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481R,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642G,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,R683L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,T250I,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,V826L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,N148D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P681R,S939F,G946R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,S680P,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,N641K,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1070S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,A292T,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 19 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,E154K,F157S,R158G,P174T,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,N703S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,K558N,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 86 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AL,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,D253Y,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,R765L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,V622A,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,V62I,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,T95I,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,Q173R,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,I1130V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,T250I,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,G1085R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,V193L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,D178H,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N137K,D138H,K150E,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,R765L,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157L,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Y674F,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 86 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187I,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,S151N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S704L,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,D1163N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1188K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,L54F,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258R,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 87 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,E583D,H625R,N641K,V642G,E654K,N679R,P681R,A688D,S704L,K795T,D796H,A852K,S939F,P1162R,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K,P681H,D796Y] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,M177I,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150R,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T747A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,Y145D,H146-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,G142N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,L517F,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,P272L,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,V826L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,A67V,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,Q173H,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A1078V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 20 +[R21T,T22N,L24S,P25N,P26Q,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683W,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 19 +[R21T,T22N,L24S,P25N,P26Q,S50L,F59S,H69-,V70-,L118I,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 20 +[R21T,T22N,L24S,P25N,P26Q,S50L,F59S,H69-,V70-,V127F,L141M,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 10 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,P1143L,H1159R,P1162L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,A958S,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 9 +[R21T,T22N,P25N,P26Q,A27L,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S884F,S939F,P1143L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,+209S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 20 +[R21T,T22N,L24S,P25N,P26Q,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 9 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 9 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,D1084G,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,V267L,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 9 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G261R,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532S,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,I1130V,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219D,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 11 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,T95I,V127F,F157S,R158G,Q173K,K182R,R190S,N211-,L212I,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1146G]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 9 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 10 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 8 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 10 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,A831V,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[L5F,R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 20 +[R21T,T22N,L24S,P25N,P26Q,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,T1006I,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 9 +[R21T,T22N,L24S,P25N,P26Q,S31P,S50L,H69-,V70-,V127F,K150E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1264L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 16 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,R683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,P272S,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,A892V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1164I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 27 +[N17M,+17P,T19F,T20N,R21F,+21I,Q23T,L24N,P25Q,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,V193L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,A942T,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16TPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,Y473F,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642G,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,G1099S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,V62L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A262V,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 9 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,P251T,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,P1143L,Q1180K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K417T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,V267L,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1164I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G257V,W258L,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,N148T,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,L864F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,A435S,V445H,G446T,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,K97N,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,V62F,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L,P1263S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,A829T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184I,N211-,L212I,V213G,L216F,H245N,A264D,T307S,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,G1124A,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335S,K356T,T376S,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T376A,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[L8F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,R273S,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,V642F,P681R,T859N,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,R683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,G142Y,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,R765L,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K147I,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621-,V622-,P681R,S691P,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532T,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 26 +[N17M,+17P,T19F,T20N,R21F,+21I,Q23T,L24N,P25Q,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478V,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 25 +[L5F,S50L,F59S,H69-,V70-,V127F,F157L,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,T573I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253Y,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529R,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V622I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 24 +[S50L,F59S,H69-,V70-,V127F,N148T,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,S98F,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1230L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,K1191R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[S31P,S50L,H69-,V70-,V127F,H146-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,I670M,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 24 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 11 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,R765H,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,G946R,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T747A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,G946R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 34 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 22 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1162L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 34 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,E554K,A570V,T572I,P621S,S939F,P1143L,P1162L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 35 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,E554K,A570V,T572I,P621S,S939F,P1143L,M1229I]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 25 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,N679K,P681H,Q954H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 25 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,D294N,I332V,K356T,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,N679K,P681H,Q954H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,P561H,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I834V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,H207Y,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,I1172V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680-,+683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,D796H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[L5I,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 11 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V395I,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,I105V,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,A899S,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 16 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,L176F,G181E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,Y145L,H146-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642G,N679R,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,K1154R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 17 +[Q14H,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,V171I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,D1184N,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 11 +[R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,E619D,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,D1084G,P1143L,N1187S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,M731I,S939F,P1143L,I1172V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,A67V,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S640Y,N641-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S689I,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,P384S,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,E156Q,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,T791A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,L226V,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,V826L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 1 +[+16MPPF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1162L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,V1133I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,A1226T]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,+209S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,S60P,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376S,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T376A,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,A93S,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,A522V,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,I569V,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339Y,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,G339H,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 12 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,Q677R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 12 +[+16MPLF,R21T,T22N,S50L,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679M,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,P862S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L,G1251V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I326V,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258C,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,T716I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 7 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 1/0 0.00042/0.00000 -0.04% -100.0% 5e-1 19 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F135L,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 24 +[R21T,T22N,S31-,S50L,H69-,V70-,V127F,E132Q,F157S,R158G,N211-,L212I,V213G,L216F,I235V,H245N,A264D,I332V,N334K,K356T,N360H,R403K,A435S,V445H,N450D,L452W,L455S,F456L,K462E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,I624M,P681R,D936G,S939F,V1104L,P1143F,D1153G,K1157R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 8 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S673T,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 4826 1 0.0% 0/1 0.00000/0.00041 +0.04% +100.0% 1e+0 6 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y]
last modified: Mon Jan 8 13:32 2024
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Questions or comments? Contact us at seq-info@lanl.gov.
