COVID-19 Viral Genome Analysis Pipeline
Enabled by data from
Frequency Changes in Common Forms
Last update: Jul 24, 2024
Download
SPIKE sequences: Exhaustive list of Last 60 days, Global, Do not break out by lineage
Compute mutations relative to XBB.1.5 baseline sequence
As new lineages emerge, there are often many sequences with many ambiguous base calls. Our pipeline filters out such sequences, and as a consequence we undercount the number of sequences in GISAID that have been specified as members of related Pango lineages. Our strategy, however, enables us to use strictly high quality sequences to identify and track the common forms in emerging lineages.
COMMON FORMS CHANGES FOR SPIKE WITH A GIVEN PANGO LINEAGE DESIGNATION
For each lineage, we show the most common forms of SPIKE, and we show the forms that are most significantly increasing or decreasing. Also shown is the Hamming distance (HD) between each form and the most common form in that lineage. Deletions relative to the baseline reference strain are indicated with a dash (e.g. the two amino acid deletion at positions 156-157 is indicated with 'E156-,F157-'), and insertions are denoted by a plus sign (e.g. an extra T at position 143 is written '+143T'). Abs Differences in later vs early fractions, expressed as percent. Relative Differences range between -100% and +100%, using formula: rel = 100*(later-early)/max(later,early) percent, applied to the early and later fractions. The p-value associated with increase or decrease is computed by Fisher's exact test, and is meant to be used only as a rough guide to the significance of the change. Since the computation is based on assumptions (such as independent and unbiased sampling) that may not hold in practice, the p-value should not be taken too literally. The first line of each lineage section indicates counts for the full lineage relative to all the sequences. 'Lineage Count' in this first line is actually the full sequence count. 'Form Count' in this first line is actually the full lineage count, and 'Form Pct' refers to lineage count relative to full sequence set.
We show all the forms.
[Note: Mutation strings are relative to baseline XBB.1.5].
This output is based on 22004 sequences sampled from 2024-05-18 to 2024-07-16
This total interval is split into two sub-intervals.
Total: 2024-05-18 to 2024-07-16 (22004)
Early: 2024-05-18 to 2024-06-09 (10923)
Later: 2024-06-10 to 2024-07-16 (11081)
Baseline XBB.1.5: [T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,D614G,H655Y,N679K,P681H,N764K,D796Y,Q954H,N969K]
Pango Lineage Form Form Counts Fractions Differences Lineage Count Count Pct Early/Later Early/Later Abs Relative pval HD [Form as mutation string] N/A 22004 4703 21.4% 2198/2505 0.20123/0.22606 +2.48% +11.0% 7e-6 0 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1104 5.0% 518/586 0.04742/0.05288 +0.55% +10.3% 6e-2 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 994 4.5% 168/826 0.01538/0.07454 +5.92% +79.4% <1e-10 1 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 774 3.5% 314/460 0.02875/0.04151 +1.28% +30.8% 3e-7 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 727 3.3% 480/247 0.04394/0.02229 -2.17% -49.3% <1e-10 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 394 1.8% 167/227 0.01529/0.02049 +0.52% +25.4% 4e-3 4 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 388 1.8% 253/135 0.02316/0.01218 -1.10% -47.4% 6e-10 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 385 1.7% 252/133 0.02307/0.01200 -1.11% -48.0% 4e-10 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 371 1.7% 271/100 0.02481/0.00902 -1.58% -63.6% <1e-10 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 290 1.3% 145/145 0.01327/0.01309 -0.02% -1.4% 9e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 257 1.2% 140/117 0.01282/0.01056 -0.23% -17.6% 1e-1 7 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 250 1.1% 162/88 0.01483/0.00794 -0.69% -46.5% 2e-6 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 244 1.1% 112/132 0.01025/0.01191 +0.17% +13.9% 2e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 229 1.0% 168/61 0.01538/0.00550 -0.99% -64.2% <1e-10 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 224 1.0% 89/135 0.00815/0.01218 +0.40% +33.1% 3e-3 4 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 192 0.9% 149/43 0.01364/0.00388 -0.98% -71.6% <1e-10 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 145 0.7% 66/79 0.00604/0.00713 +0.11% +15.2% 4e-1 5 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 142 0.6% 108/34 0.00989/0.00307 -0.68% -69.0% 2e-10 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 133 0.6% 121/12 0.01108/0.00108 -1.00% -90.2% <1e-10 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 120 0.5% 59/61 0.00540/0.00550 +0.01% +1.9% 9e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 118 0.5% 51/67 0.00467/0.00605 +0.14% +22.8% 2e-1 7 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 112 0.5% 46/66 0.00421/0.00596 +0.17% +29.3% 7e-2 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 105 0.5% 23/82 0.00211/0.00740 +0.53% +71.5% 6e-9 5 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 99 0.4% 75/24 0.00687/0.00217 -0.47% -68.5% 1e-7 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 98 0.4% 45/53 0.00412/0.00478 +0.07% +13.9% 5e-1 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 92 0.4% 42/50 0.00385/0.00451 +0.07% +14.8% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 87 0.4% 30/57 0.00275/0.00514 +0.24% +46.6% 5e-3 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 84 0.4% 74/10 0.00677/0.00090 -0.59% -86.7% <1e-10 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 77 0.3% 24/53 0.00220/0.00478 +0.26% +54.1% 1e-3 2 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 72 0.3% 50/22 0.00458/0.00199 -0.26% -56.6% 8e-4 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 65 0.3% 34/31 0.00311/0.00280 -0.03% -10.1% 7e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 65 0.3% 18/47 0.00165/0.00424 +0.26% +61.1% 4e-4 1 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 65 0.3% 25/40 0.00229/0.00361 +0.13% +36.6% 8e-2 4 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 62 0.3% 24/38 0.00220/0.00343 +0.12% +35.9% 1e-1 1 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 54 0.2% 49/5 0.00449/0.00045 -0.40% -89.9% 2e-10 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 52 0.2% 32/20 0.00293/0.00180 -0.11% -38.4% 1e-1 1 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 52 0.2% 27/25 0.00247/0.00226 -0.02% -8.7% 8e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 49 0.2% 35/14 0.00320/0.00126 -0.19% -60.6% 2e-3 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 48 0.2% 2/46 0.00018/0.00415 +0.40% +95.6% <1e-10 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 47 0.2% 25/22 0.00229/0.00199 -0.03% -13.3% 7e-1 4 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 45 0.2% 17/28 0.00156/0.00253 +0.10% +38.4% 1e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 44 0.2% 27/17 0.00247/0.00153 -0.09% -37.9% 1e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 42 0.2% 17/25 0.00156/0.00226 +0.07% +31.0% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 42 0.2% 13/29 0.00119/0.00262 +0.14% +54.5% 2e-2 8 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 41 0.2% 23/18 0.00211/0.00162 -0.05% -22.9% 4e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 41 0.2% 17/24 0.00156/0.00217 +0.06% +28.1% 3e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 40 0.2% 37/3 0.00339/0.00027 -0.31% -92.0% 8e-9 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 40 0.2% 33/7 0.00302/0.00063 -0.24% -79.1% 2e-5 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 38 0.2% 26/12 0.00238/0.00108 -0.13% -54.5% 2e-2 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 38 0.2% 27/11 0.00247/0.00099 -0.15% -59.8% 9e-3 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 38 0.2% 31/7 0.00284/0.00063 -0.22% -77.7% 6e-5 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] (consensus) N/A 22004 37 0.2% 18/19 0.00165/0.00171 +0.01% +3.9% 1e+0 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 37 0.2% 25/12 0.00229/0.00108 -0.12% -52.7% 3e-2 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 37 0.2% 27/10 0.00247/0.00090 -0.16% -63.5% 5e-3 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 37 0.2% 31/6 0.00284/0.00054 -0.23% -80.9% 2e-5 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 36 0.2% 30/6 0.00275/0.00054 -0.22% -80.3% 4e-5 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 36 0.2% 4/32 0.00037/0.00289 +0.25% +87.3% 2e-6 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642A,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 35 0.2% 24/11 0.00220/0.00099 -0.12% -54.8% 3e-2 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 34 0.2% 23/11 0.00211/0.00099 -0.11% -52.9% 4e-2 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 34 0.2% 8/26 0.00073/0.00235 +0.16% +68.8% 3e-3 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 32 0.1% 10/22 0.00092/0.00199 +0.11% +53.9% 5e-2 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 32 0.1% 22/10 0.00201/0.00090 -0.11% -55.2% 3e-2 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 31 0.1% 13/18 0.00119/0.00162 +0.04% +26.7% 5e-1 2 +[+16MPLF,R21-,+22I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 30 0.1% 9/21 0.00082/0.00190 +0.11% +56.5% 4e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D745G,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 30 0.1% 19/11 0.00174/0.00099 -0.07% -42.9% 1e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 30 0.1% 6/24 0.00055/0.00217 +0.16% +74.6% 1e-3 6 +[+16MPLF,R21-,+22N,S31F,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 29 0.1% 13/16 0.00119/0.00144 +0.03% +17.6% 7e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 29 0.1% 10/19 0.00092/0.00171 +0.08% +46.6% 1e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,S477D,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,S477N,E484A,F490S,P681H] N/A 22004 28 0.1% 5/23 0.00046/0.00208 +0.16% +77.9% 9e-4 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I844V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 28 0.1% 12/16 0.00110/0.00144 +0.03% +23.9% 6e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 28 0.1% 3/25 0.00027/0.00226 +0.20% +87.8% 3e-5 1 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 27 0.1% 15/12 0.00137/0.00108 -0.03% -21.1% 6e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 27 0.1% 6/21 0.00055/0.00190 +0.13% +71.0% 6e-3 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 26 0.1% 21/5 0.00192/0.00045 -0.15% -76.5% 1e-3 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 26 0.1% 11/15 0.00101/0.00135 +0.03% +25.6% 6e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 25 0.1% 10/15 0.00092/0.00135 +0.04% +32.4% 4e-1 4 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 25 0.1% 11/14 0.00101/0.00126 +0.03% +20.3% 7e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 25 0.1% 10/15 0.00092/0.00135 +0.04% +32.4% 4e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 25 0.1% 2/23 0.00018/0.00208 +0.19% +91.2% 2e-5 2 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 24 0.1% 9/15 0.00082/0.00135 +0.05% +39.1% 3e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V382L,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 24 0.1% 9/15 0.00082/0.00135 +0.05% +39.1% 3e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 24 0.1% 24/0 0.00220/0.00000 -0.22% -100.0% 5e-8 7 +[R21T,S50L,H69-,V70-,V127F,K150I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 23 0.1% 3/20 0.00027/0.00180 +0.15% +84.8% 5e-4 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 23 0.1% 12/11 0.00110/0.00099 -0.01% -9.6% 8e-1 1 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 23 0.1% 10/13 0.00092/0.00117 +0.03% +22.0% 7e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 23 0.1% 19/4 0.00174/0.00036 -0.14% -79.2% 1e-3 4 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 22 0.1% 9/13 0.00082/0.00117 +0.03% +29.8% 5e-1 1 +[+16MPLF,R21T,P39L,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 22 0.1% 13/9 0.00119/0.00081 -0.04% -31.8% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 22 0.1% 8/14 0.00073/0.00126 +0.05% +42.0% 3e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 22 0.1% 8/14 0.00073/0.00126 +0.05% +42.0% 3e-1 4 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 21 0.1% 14/7 0.00128/0.00063 -0.06% -50.7% 1e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 21 0.1% 8/13 0.00073/0.00117 +0.04% +37.6% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 21 0.1% 15/6 0.00137/0.00054 -0.08% -60.6% 5e-2 5 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 21 0.1% 8/13 0.00073/0.00117 +0.04% +37.6% 4e-1 4 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 21 0.1% 11/10 0.00101/0.00090 -0.01% -10.4% 8e-1 11 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 20 0.1% 18/2 0.00165/0.00018 -0.15% -89.0% 2e-4 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K417T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 20 0.1% 7/13 0.00064/0.00117 +0.05% +45.4% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 20 0.1% 12/8 0.00110/0.00072 -0.04% -34.3% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 19 0.1% 16/3 0.00146/0.00027 -0.12% -81.5% 2e-3 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 19 0.1% 8/11 0.00073/0.00099 +0.03% +26.2% 6e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 18 0.1% 14/4 0.00128/0.00036 -0.09% -71.8% 2e-2 3 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 18 0.1% 5/13 0.00046/0.00117 +0.07% +61.0% 1e-1 3 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 18 0.1% 1/17 0.00009/0.00153 +0.14% +94.0% 1e-4 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 18 0.1% 10/8 0.00092/0.00072 -0.02% -21.1% 6e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 18 0.1% 4/14 0.00037/0.00126 +0.09% +71.0% 3e-2 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,P217S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N1125S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 18 0.1% 16/2 0.00146/0.00018 -0.13% -87.7% 7e-4 4 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 17 0.1% 12/5 0.00110/0.00045 -0.06% -58.9% 9e-2 9 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 17 0.1% 9/8 0.00082/0.00072 -0.01% -12.4% 8e-1 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 17 0.1% 15/2 0.00137/0.00018 -0.12% -86.9% 1e-3 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 16 0.1% 15/1 0.00137/0.00009 -0.13% -93.4% 3e-4 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 16 0.1% 7/9 0.00064/0.00081 +0.02% +21.1% 8e-1 7 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 15 0.1% 8/7 0.00073/0.00063 -0.01% -13.7% 8e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,A1174V]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 15 0.1% 13/2 0.00119/0.00018 -0.10% -84.8% 4e-3 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 15 0.1% 4/11 0.00037/0.00099 +0.06% +63.1% 1e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 15 0.1% 8/7 0.00073/0.00063 -0.01% -13.7% 8e-1 5 +[+16MPLF,R21T,S50L,H69F,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 15 0.1% 7/8 0.00064/0.00072 +0.01% +11.2% 1e+0 2 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 15 0.1% 7/8 0.00064/0.00072 +0.01% +11.2% 1e+0 3 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 15 0.1% 14/1 0.00128/0.00009 -0.12% -93.0% 5e-4 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 14 0.1% 11/3 0.00101/0.00027 -0.07% -73.1% 3e-2 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 14 0.1% 4/10 0.00037/0.00090 +0.05% +59.4% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 14 0.1% 12/2 0.00110/0.00018 -0.09% -83.6% 7e-3 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 14 0.1% 12/2 0.00110/0.00018 -0.09% -83.6% 7e-3 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 14 0.1% 11/3 0.00101/0.00027 -0.07% -73.1% 3e-2 2 +[+16IPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 14 0.1% 12/2 0.00110/0.00018 -0.09% -83.6% 7e-3 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V407I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 14 0.1% 4/10 0.00037/0.00090 +0.05% +59.4% 2e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N148T,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 14 0.1% 11/3 0.00101/0.00027 -0.07% -73.1% 3e-2 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 14 0.1% 5/9 0.00046/0.00081 +0.04% +43.6% 4e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,S151I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 14 0.1% 7/7 0.00064/0.00063 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 14 0.1% 5/9 0.00046/0.00081 +0.04% +43.6% 4e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R765L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 13 0.1% 12/1 0.00110/0.00009 -0.10% -91.8% 2e-3 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 13 0.1% 0/13 0.00000/0.00117 +0.12% +100.0% 2e-4 2 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 13 0.1% 6/7 0.00055/0.00063 +0.01% +13.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 13 0.1% 10/3 0.00092/0.00027 -0.06% -70.4% 6e-2 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 13 0.1% 2/11 0.00018/0.00099 +0.08% +81.6% 2e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 13 0.1% 2/11 0.00018/0.00099 +0.08% +81.6% 2e-2 11 +[N17M,+17P,+18FNI,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 13 0.1% 12/1 0.00110/0.00009 -0.10% -91.8% 2e-3 4 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 13 0.1% 3/10 0.00027/0.00090 +0.06% +69.6% 9e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,L84I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 13 0.1% 4/9 0.00037/0.00081 +0.04% +54.9% 3e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 13 0.1% 9/4 0.00082/0.00036 -0.05% -56.2% 2e-1 8 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 13 0.1% 8/5 0.00073/0.00045 -0.03% -38.4% 4e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q675R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 7/5 0.00064/0.00045 -0.02% -29.6% 6e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 3/9 0.00027/0.00081 +0.05% +66.2% 1e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 5/7 0.00046/0.00063 +0.02% +27.5% 8e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 12 0.1% 4/8 0.00037/0.00072 +0.04% +49.3% 4e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258R,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 10/2 0.00092/0.00018 -0.07% -80.3% 2e-2 3 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 7/5 0.00064/0.00045 -0.02% -29.6% 6e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 10/2 0.00092/0.00018 -0.07% -80.3% 2e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 2/10 0.00018/0.00090 +0.07% +79.7% 4e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 8/4 0.00073/0.00036 -0.04% -50.7% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,D80Y,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 7/5 0.00064/0.00045 -0.02% -29.6% 6e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 1/11 0.00009/0.00099 +0.09% +90.8% 6e-3 5 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 3/9 0.00027/0.00081 +0.05% +66.2% 1e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 12 0.1% 2/10 0.00018/0.00090 +0.07% +79.7% 4e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K304N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 4/8 0.00037/0.00072 +0.04% +49.3% 4e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,L84V,V127F,F157S,R158G,Q173K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 2/10 0.00018/0.00090 +0.07% +79.7% 4e-2 1 +[L5I,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 12/0 0.00110/0.00000 -0.11% -100.0% 2e-4 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S698L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 12 0.1% 1/11 0.00009/0.00099 +0.09% +90.8% 6e-3 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 2/9 0.00018/0.00081 +0.06% +77.5% 7e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 6/5 0.00055/0.00045 -0.01% -17.9% 8e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 9/2 0.00082/0.00018 -0.06% -78.1% 4e-2 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 7/4 0.00064/0.00036 -0.03% -43.7% 4e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P793S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 5/6 0.00046/0.00054 +0.01% +15.5% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 7/4 0.00064/0.00036 -0.03% -43.7% 4e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 11 0.0% 7/4 0.00064/0.00036 -0.03% -43.7% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 4/7 0.00037/0.00063 +0.03% +42.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 0/11 0.00000/0.00099 +0.10% +100.0% 1e-3 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 4/7 0.00037/0.00063 +0.03% +42.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 11 0.0% 11/0 0.00101/0.00000 -0.10% -100.0% 4e-4 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,F1103S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 7/4 0.00064/0.00036 -0.03% -43.7% 4e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,N556K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 2/9 0.00018/0.00081 +0.06% +77.5% 7e-2 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 4/7 0.00037/0.00063 +0.03% +42.0% 5e-1 11 +[R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 11 0.0% 1/10 0.00009/0.00090 +0.08% +89.9% 1e-2 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 10 0.0% 6/4 0.00055/0.00036 -0.02% -34.3% 5e-1 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 1/9 0.00009/0.00081 +0.07% +88.7% 2e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 7/3 0.00064/0.00027 -0.04% -57.8% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 10 0.0% 7/3 0.00064/0.00027 -0.04% -57.8% 2e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 6/4 0.00055/0.00036 -0.02% -34.3% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441V,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 7/3 0.00064/0.00027 -0.04% -57.8% 2e-1 1 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 5/5 0.00046/0.00045 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 6/4 0.00055/0.00036 -0.02% -34.3% 5e-1 3 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 5/5 0.00046/0.00045 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 3/7 0.00027/0.00063 +0.04% +56.5% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T299I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 4/6 0.00037/0.00054 +0.02% +32.4% 8e-1 6 +[+16MPLF,R21T,S50L,F59S,F65Y,H69-,V70-,V127F,F157S,R158G,Q183P,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 3/7 0.00027/0.00063 +0.04% +56.5% 3e-1 6 +[+16MPLF,R21-,+22N,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 5/5 0.00046/0.00045 -0.00% -1.4% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 8/2 0.00073/0.00018 -0.06% -75.4% 6e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 10 0.0% 6/4 0.00055/0.00036 -0.02% -34.3% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 10 0.0% 3/7 0.00027/0.00063 +0.04% +56.5% 3e-1 5 +[+16MPLF,R21T,T33A,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 6/3 0.00055/0.00027 -0.03% -50.7% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,E309Q,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 3/6 0.00027/0.00054 +0.03% +49.3% 5e-1 1 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 8/1 0.00073/0.00009 -0.06% -87.7% 2e-2 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q239R,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 1/8 0.00009/0.00072 +0.06% +87.3% 4e-2 1 +[+16MPLF,R21T,V36I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 4/5 0.00037/0.00045 +0.01% +18.8% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P793T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 1/8 0.00009/0.00072 +0.06% +87.3% 4e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N149S,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 9 0.0% 3/6 0.00027/0.00054 +0.03% +49.3% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 6/3 0.00055/0.00027 -0.03% -50.7% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157L,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 2/7 0.00018/0.00063 +0.04% +71.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,A942T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 1/8 0.00009/0.00072 +0.06% +87.3% 4e-2 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 1/8 0.00009/0.00072 +0.06% +87.3% 4e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237M,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 8/1 0.00073/0.00009 -0.06% -87.7% 2e-2 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 6/3 0.00055/0.00027 -0.03% -50.7% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 6/3 0.00055/0.00027 -0.03% -50.7% 3e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,P251S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 7/2 0.00064/0.00018 -0.05% -71.8% 1e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,R78S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1228A]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 1/8 0.00009/0.00072 +0.06% +87.3% 4e-2 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,L189F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 2/7 0.00018/0.00063 +0.04% +71.0% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q173R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 0/9 0.00000/0.00081 +0.08% +100.0% 4e-3 1 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 0/9 0.00000/0.00081 +0.08% +100.0% 4e-3 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,Y269H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 8/1 0.00073/0.00009 -0.06% -87.7% 2e-2 11 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 9/0 0.00082/0.00000 -0.08% -100.0% 2e-3 4 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 9 0.0% 8/1 0.00073/0.00009 -0.06% -87.7% 2e-2 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 6/2 0.00055/0.00018 -0.04% -67.1% 2e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 4/4 0.00037/0.00036 -0.00% -1.4% 1e+0 2 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 5/3 0.00046/0.00027 -0.02% -40.9% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 4/4 0.00037/0.00036 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 5/3 0.00046/0.00027 -0.02% -40.9% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 3/5 0.00027/0.00045 +0.02% +39.1% 7e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 5/3 0.00046/0.00027 -0.02% -40.9% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 5/3 0.00046/0.00027 -0.02% -40.9% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 8 0.0% 4/4 0.00037/0.00036 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 4/4 0.00037/0.00036 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 4/4 0.00037/0.00036 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,D1084H,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 3/5 0.00027/0.00045 +0.02% +39.1% 7e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,D1153G]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 6/2 0.00055/0.00018 -0.04% -67.1% 2e-1 4 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 7/1 0.00064/0.00009 -0.06% -85.9% 4e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,I651V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 3/5 0.00027/0.00045 +0.02% +39.1% 7e-1 7 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 0/8 0.00000/0.00072 +0.07% +100.0% 8e-3 2 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D745G,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 5/3 0.00046/0.00027 -0.02% -40.9% 5e-1 3 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 0/8 0.00000/0.00072 +0.07% +100.0% 8e-3 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 8/0 0.00073/0.00000 -0.07% -100.0% 4e-3 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 8/0 0.00073/0.00000 -0.07% -100.0% 4e-3 8 +[R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 8 0.0% 1/7 0.00009/0.00063 +0.05% +85.5% 7e-2 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 3/4 0.00027/0.00036 +0.01% +23.9% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 4/3 0.00037/0.00027 -0.01% -26.1% 7e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 4/3 0.00037/0.00027 -0.01% -26.1% 7e-1 10 +[+16MPLF,R21T,Y28H,S50L,H69-,V70-,V127F,F157S,R158G,G184A,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 5/2 0.00046/0.00018 -0.03% -60.6% 3e-1 1 +[+16MPLF,R21T,S50L,F58L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 2/5 0.00018/0.00045 +0.03% +59.4% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 5/2 0.00046/0.00018 -0.03% -60.6% 3e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211T,L212G,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 4/3 0.00037/0.00027 -0.01% -26.1% 7e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,F186W,K187-,N188-,L189-,R190-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 5/2 0.00046/0.00018 -0.03% -60.6% 3e-1 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 5/2 0.00046/0.00018 -0.03% -60.6% 3e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 7 0.0% 7/0 0.00064/0.00000 -0.06% -100.0% 7e-3 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,D287E,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 6/1 0.00055/0.00009 -0.05% -83.6% 7e-2 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 2/5 0.00018/0.00045 +0.03% +59.4% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 5/2 0.00046/0.00018 -0.03% -60.6% 3e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 1/6 0.00009/0.00054 +0.04% +83.1% 1e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P793S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 3/4 0.00027/0.00036 +0.01% +23.9% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 3/4 0.00027/0.00036 +0.01% +23.9% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,A575S,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 3/4 0.00027/0.00036 +0.01% +23.9% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,G72E,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 7/0 0.00064/0.00000 -0.06% -100.0% 7e-3 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 3/4 0.00027/0.00036 +0.01% +23.9% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,H146K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 2/5 0.00018/0.00045 +0.03% +59.4% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 3/4 0.00027/0.00036 +0.01% +23.9% 1e+0 13 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 7 0.0% 3/4 0.00027/0.00036 +0.01% +23.9% 1e+0 5 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 7 0.0% 2/5 0.00018/0.00045 +0.03% +59.4% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G184D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 2/5 0.00018/0.00045 +0.03% +59.4% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 4/3 0.00037/0.00027 -0.01% -26.1% 7e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1070S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 5/2 0.00046/0.00018 -0.03% -60.6% 3e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 7 0.0% 3/4 0.00027/0.00036 +0.01% +23.9% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G261R,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 5/2 0.00046/0.00018 -0.03% -60.6% 3e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 2/5 0.00018/0.00045 +0.03% +59.4% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 5/2 0.00046/0.00018 -0.03% -60.6% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679M,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 7 0.0% 0/7 0.00000/0.00063 +0.06% +100.0% 2e-2 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 0/7 0.00000/0.00063 +0.06% +100.0% 2e-2 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,K529N,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 0/7 0.00000/0.00063 +0.06% +100.0% 2e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,V772I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 2/5 0.00018/0.00045 +0.03% +59.4% 5e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 2/5 0.00018/0.00045 +0.03% +59.4% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 0/7 0.00000/0.00063 +0.06% +100.0% 2e-2 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,G72R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 0/7 0.00000/0.00063 +0.06% +100.0% 2e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 5/2 0.00046/0.00018 -0.03% -60.6% 3e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 7/0 0.00064/0.00000 -0.06% -100.0% 7e-3 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,S1252F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 6/1 0.00055/0.00009 -0.05% -83.6% 7e-2 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 7 0.0% 0/7 0.00000/0.00063 +0.06% +100.0% 2e-2 2 +[+16MPLF,R21T,T33I,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N960S,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 5/1 0.00046/0.00009 -0.04% -80.3% 1e-1 8 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K278E,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K964R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 2/4 0.00018/0.00036 +0.02% +49.3% 7e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,G72R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 6/0 0.00055/0.00000 -0.05% -100.0% 1e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 0/6 0.00000/0.00054 +0.05% +100.0% 3e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1241F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 0/6 0.00000/0.00054 +0.05% +100.0% 3e-2 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,S155N,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 7 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 5/1 0.00046/0.00009 -0.04% -80.3% 1e-1 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 5/1 0.00046/0.00009 -0.04% -80.3% 1e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1020S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,K113T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 2/4 0.00018/0.00036 +0.02% +49.3% 7e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 3 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 2/4 0.00018/0.00036 +0.02% +49.3% 7e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547I,E554K,A570V,P621S,N641K,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 1 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 2/4 0.00018/0.00036 +0.02% +49.3% 7e-1 6 +[+16MPLF,R21T,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 6 0.0% 2/4 0.00018/0.00036 +0.02% +49.3% 7e-1 3 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 5/1 0.00046/0.00009 -0.04% -80.3% 1e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,R246K,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 0/6 0.00000/0.00054 +0.05% +100.0% 3e-2 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A845S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 6/0 0.00055/0.00000 -0.05% -100.0% 1e-2 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K964R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,I1114T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 0/6 0.00000/0.00054 +0.05% +100.0% 3e-2 4 +[+16MPLF,R21T,F32-,S50L,W64R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 0/6 0.00000/0.00054 +0.05% +100.0% 3e-2 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,I1114F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 2/4 0.00018/0.00036 +0.02% +49.3% 7e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681-,+683W,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 11 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 0/6 0.00000/0.00054 +0.05% +100.0% 3e-2 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 5/1 0.00046/0.00009 -0.04% -80.3% 1e-1 3 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,T76I,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 0/6 0.00000/0.00054 +0.05% +100.0% 3e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 6 0.0% 6/0 0.00055/0.00000 -0.05% -100.0% 1e-2 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 5/1 0.00046/0.00009 -0.04% -80.3% 1e-1 4 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 0/6 0.00000/0.00054 +0.05% +100.0% 3e-2 5 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 5/1 0.00046/0.00009 -0.04% -80.3% 1e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 6/0 0.00055/0.00000 -0.05% -100.0% 1e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 0/6 0.00000/0.00054 +0.05% +100.0% 3e-2 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,A352S,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 6 0.0% 5/1 0.00046/0.00009 -0.04% -80.3% 1e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 4/2 0.00037/0.00018 -0.02% -50.7% 4e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 1/5 0.00009/0.00045 +0.04% +79.7% 2e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 6/0 0.00055/0.00000 -0.05% -100.0% 1e-2 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 6/0 0.00055/0.00000 -0.05% -100.0% 1e-2 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 6/0 0.00055/0.00000 -0.05% -100.0% 1e-2 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K417T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 6 0.0% 0/6 0.00000/0.00054 +0.05% +100.0% 3e-2 3 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 5 +[+16MPLF,R21T,S50L,S60P,W64L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 4/1 0.00037/0.00009 -0.03% -75.4% 2e-1 8 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 2/3 0.00018/0.00027 +0.01% +32.4% 1e+0 5 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 1/4 0.00009/0.00036 +0.03% +74.6% 4e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,K535T,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 4/1 0.00037/0.00009 -0.03% -75.4% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 1/4 0.00009/0.00036 +0.03% +74.6% 4e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 4/1 0.00037/0.00009 -0.03% -75.4% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,S162G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 1/4 0.00009/0.00036 +0.03% +74.6% 4e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 2/3 0.00018/0.00027 +0.01% +32.4% 1e+0 5 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 4/1 0.00037/0.00009 -0.03% -75.4% 2e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681-,+683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 5 +[+16MPLF,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 4/1 0.00037/0.00009 -0.03% -75.4% 2e-1 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 2/3 0.00018/0.00027 +0.01% +32.4% 1e+0 9 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 5 0.0% 2/3 0.00018/0.00027 +0.01% +32.4% 1e+0 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,R346K,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 5 0.0% 2/3 0.00018/0.00027 +0.01% +32.4% 1e+0 6 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,K147E,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Y660R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 5 +[+16MPLF,R21T,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 1/4 0.00009/0.00036 +0.03% +74.6% 4e-1 5 +[+16MPLF,R21T,F32-,S50L,W64R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441F,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 0/5 0.00000/0.00045 +0.05% +100.0% 6e-2 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,S940F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 4/1 0.00037/0.00009 -0.03% -75.4% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 3 +[+16MPLF,R21T,S50L,L56V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 5 +[+16MPLF,R21T,S31-,S50L,F65S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,E1092D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 1/4 0.00009/0.00036 +0.03% +74.6% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 1/4 0.00009/0.00036 +0.03% +74.6% 4e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 1/4 0.00009/0.00036 +0.03% +74.6% 4e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 1/4 0.00009/0.00036 +0.03% +74.6% 4e-1 7 +[+16MPLF,R21-,+22N,S50L,F58L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 0/5 0.00000/0.00045 +0.05% +100.0% 6e-2 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,P251L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 1/4 0.00009/0.00036 +0.03% +74.6% 4e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 2 +[+16MPVF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,F275L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681-,+683Q,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 7 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 2/3 0.00018/0.00027 +0.01% +32.4% 1e+0 11 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 4/1 0.00037/0.00009 -0.03% -75.4% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 4/1 0.00037/0.00009 -0.03% -75.4% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478Q,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 5 0.0% 3/2 0.00027/0.00018 -0.01% -34.3% 7e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 0/5 0.00000/0.00045 +0.05% +100.0% 6e-2 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 1/4 0.00009/0.00036 +0.03% +74.6% 4e-1 5 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 2/3 0.00018/0.00027 +0.01% +32.4% 1e+0 9 +[R21T,T33A,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 0/5 0.00000/0.00045 +0.05% +100.0% 6e-2 5 +[+16MPLF,R21T,S50L,H69-,V70-,D80Y,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 4/1 0.00037/0.00009 -0.03% -75.4% 2e-1 13 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 16 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 13 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 7 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,N334K,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 4/1 0.00037/0.00009 -0.03% -75.4% 2e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S689R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1176F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 5 0.0% 5/0 0.00046/0.00000 -0.05% -100.0% 3e-2 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 4 +[+16MPLF,R21T,N30D,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,F306L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 8 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V622A,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 5 +[S13T,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,D138N,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 4 +[+16KPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 5 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 1 +[+16MPLF,R21T,T33K,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258C,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 9 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 10 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 8 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,+374F,T376-,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S375F,T376A,V445P,E484A,F490S] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 5 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 3 +[+16MPLF,R21T,F32V,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 4 +[+16MPLF,R21T,N30H,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250I,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q218H,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,Q613H,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 5 +[+16MPLF,R21T,S31-,S50L,F65Y,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,W152R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S31P,S50L,F58Y,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 4 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,Q183H,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 6 +[L5F,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A684T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 2 +[+16MPLF,R21T,H49Q,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1235F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,Q957R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 7 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,K187R,N211T,L212G,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V382L,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478R,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,H1058Y,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,H1088R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V635I,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q173E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 9 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1263L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F175L,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 2 +[+16MPLF,R21T,G35R,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 10 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,V193L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 6 +[+16MPLF,R21T,S31-,S50L,H69Y,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 6 +[R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 1/3 0.00009/0.00027 +0.02% +66.2% 6e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 8 +[R21T,S31-,S50L,H69-,V70-,G72E,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,R765L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,H519Y,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,T478E,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 11 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 16 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 6 +[R21T,S31-,H49Y,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 4 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,K182I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A771S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 2/2 0.00018/0.00018 -0.00% -1.4% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 0/4 0.00000/0.00036 +0.04% +100.0% 1e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,K187R,R190S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 3/1 0.00027/0.00009 -0.02% -67.1% 4e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T274N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,V171F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 6 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 3 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 4 0.0% 4/0 0.00037/0.00000 -0.04% -100.0% 6e-2 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I931V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,G75V,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 8 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N960S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,K182R,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 7 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 1 +[+16LPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,K529T,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 8 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,+209T,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D796H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V407I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q173E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 12 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 6 +[+16MPLF,R21T,S31-,R34C,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 13 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,Y453F,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,D138H,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D936E,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[S12F,+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 9 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 8 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,R634H,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N148T,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 9 +[+16MPLF,R21-,+22N,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,H1101Y,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N501Y,Y505H,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N148S,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V171L,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T747I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 4 +[+16MPLF,R21T,S31Y,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 4 +[+16MPLF,R21T,F32-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445Y,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[+16MPLF,R21T,N30I,S31-,F32-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,D1260Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,Q613H,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,N137K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 5 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 8 +[+16MPLF,R21-,+22N,S31F,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I934V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,V826M,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255-,S256-,G257-,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 3 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,E1202Q]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,H1083Y,V1104L,P1143L,M1237I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441V,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,I651V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 5 +[+16MPLF,R21T,S31-,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 6 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,R1185H]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 10 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,P217S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N1125S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S704L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,R567K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,I100L,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 7 +[+16MPLF,R21T,A27-,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 7 +[+16MPLF,R21T,F59S,F65Y,H69-,V70-,V127F,F157S,R158G,Q183P,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 5 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 4 +[+16MPLF,R21T,S31P,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D745A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,P217H,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 6 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 4 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,S155I,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 6 +[L5F,+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,E180D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,I1132V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N188D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 4 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 10 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,H146-,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,E780A,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,S940F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,F377L,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680Y,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A845S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 6 +[+16MPLF,R21-,+22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,P384S,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N960S,P1143L,S1252F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A243N,L244-,H245-,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,V1122A,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T732I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 3 +[+16IPLF,R21T,S50L,H69-,V70-,V127F,D138G,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,E1092A,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 6 +[+16MPLF,R21T,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 9 +[R21T,S31-,S50L,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 1 +[+16MPLF,R21T,H49Y,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 3 +[+16MPLF,+18V,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 6 +[R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D936H,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 9 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683L,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 8 +[R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258R,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 5 +[R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,F186S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,H146K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1157N]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 2 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,S255-,S256-,G257-,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,N148T,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1020S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T284I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 1/2 0.00009/0.00018 +0.01% +49.3% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,E154Q,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A879S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 11 +[+19I,R21-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,P251H,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,D1259Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,H1088R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 6 +[+16MPLF,R21T,S50L,T51I,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,F186L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,D111N,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 4 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 3 +[+16MPLF,R21T,S50L,F58S,H69-,V70-,K77M,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 6 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,R273S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 0/3 0.00000/0.00027 +0.03% +100.0% 3e-1 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L,K1191N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A845V,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 8 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N185S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L,D1168G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 3/0 0.00027/0.00000 -0.03% -100.0% 1e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,V736I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 3 0.0% 2/1 0.00018/0.00009 -0.01% -50.7% 6e-1 5 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,S940F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,E780A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1168E]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 10 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182Q,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,G1219C]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,V308L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,M177T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1112Q,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A771S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,A1174V,E1195Q]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A942V,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S691P,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 2 +[+16MPL,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 16 +[R21T,S50L,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 9 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,Q1180K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P793S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,I1232V]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[L5F,+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,G75V,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181R,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,V267L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 13 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,R408S,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,C1247S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257D,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[+16MPLF,R21T,S31-,S50L,H69Y,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D796H,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 11 +[R21-,+22I,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1237I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 8 +[R21T,S50L,I68M,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I285V,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 9 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 8 +[R21T,S50L,F65Y,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 12 +[N17M,+17P,+18FNII,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,L1197F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,P85L,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[+16MPLF,R21T,S50L,I68T,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T732I,A845S,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,D745G,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S256P,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 2 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P793S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 11 +[+16MPLF,R21T,Y28H,S50L,H69-,V70-,N121D,V127F,F157S,R158G,G184A,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T827A,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1078S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 11 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q218E,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1228L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,E1202Q]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V120I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 8 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,N334K,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181A,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,P85S,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A831V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257R,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,R78M,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 10 +[+19I,R21-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A684S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,P85S,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,F565L,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,T76I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 10 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 10 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,N334S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I909V,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T747A,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 11 +[+16MPLF,R21T,Y28H,S50L,H69-,V70-,V127F,F157S,R158G,G184A,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,E654Q,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,W258-,T259-,G261-,A263D,A264-,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,A344V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I844V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,M153V,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T941A,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[F4C,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,M731I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N960S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,P251H,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,M1237I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N641Y,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 9 +[+16MPLF,+18V,R21-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,L585F,P621S,P681R,S939F,P1143L,P1263L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,N1178D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,A67V,H69-,V70-,V127F,F157S,R158G,Q183H,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[L5F,+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481R,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,G1219C]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,D80N,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 11 +[R21T,L24S,P25T,P26Q,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[L24-,P25-,P26-,V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H,Q954H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 8 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L179P,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[L5F,+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,L56V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1122M,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,K187I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T791I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[+16MPLF,R21T,G35V,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,I1225V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,P251L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I119V,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F58S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,G639S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,D178N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A783V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,T29I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,F32-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,K558N,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 8 +[+16MPLF,R21T,N30S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,Y28H,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A845V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 7 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 13 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,V551I,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 8 +[R21T,N30K,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I934V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,Q804K,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 9 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679T,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,G476-,T478N,+478K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,A684T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 7 +[R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 8 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478R,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 13 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N137-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,N148-,N149-,K150-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S31F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,K182R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,I1114V,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,D1199N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1070T,H1083Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G261C,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,D574N,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,E309Q,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D936N,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,A522V,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,D253Y,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R765L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486L,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,H1083Y,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1020V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[V6A,+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,I105L,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 12 +[N17M,+17P,+18FNFI,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681-,+683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A846V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,M153V,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V622F,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,L1200F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P812L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N501Y,Y505H,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 14 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 13 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[L5F,+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V622A,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,Y269H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,P85S,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L,Q1180K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I834S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,A623-,I624-,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1020V,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 10 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,+370F,A372P,S373F,S375A,T376-,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S371F,S373P,S375F,T376A,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V622A,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V83I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,G1219C]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 10 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,K187R,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 11 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,E1202A]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,H1083Y,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,I1225T]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,D253A,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,Q787K,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,D1199V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157L,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T761A,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPVF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,N334K,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 9 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G252S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,V615I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21-,+22I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D745G,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 8 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N657K,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1162S]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A893S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T573I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[+16MPLF,R21-,+22N,S31F,S50L,T63N,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478Q,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P793S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,R78S,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1228A]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 7 +[L5F,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,H1101Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 8 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,E1150D]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,S60A,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 11 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,S50L,F59I,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 10 +[R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A845S,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,Q1002H,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,G181E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1237I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V382L,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E471Q,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T470I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,E1092D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 14 +[S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T284I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A879T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[L5F,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,W152G,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,R765L,S939F,P1143L,K1181E]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,E1195Q]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,A344S,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,L1224F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,S1242I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,S112P,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,C1247S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237M,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H,N764K] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D820E,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,G35V,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,E154G,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,T33I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[L5F,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452R,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1263T]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,N282S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N148D,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I326V,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,P251S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G261-,+264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,F186L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,P384S,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 18 +[N17M,+17P,+18FNFI,R21-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,D80Y,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,N1187K]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,E1202Q]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,T124I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1070S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S50L,L54S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,A344S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,P479L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,M177I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,G946R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,G72R,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 12 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 14 +[R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 10 +[R21T,S50L,H69-,V70-,V127F,M153I,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 12 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 11 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 13 +[L18F,+18I,R21-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 11 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547I,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 9 +[L5F,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 8 +[+16MPLF,R21-,+22N,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,L118F,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[L5F,R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 9 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,V159A,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,A1087S,P1143L,E1188V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[+16MPLF,R21-,+22N,S31P,S50L,F58Y,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 9 +[+16MPLF,R21-,+22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,Y453F,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,D111N,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 10 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K150R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681-,+683Q,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,F32S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T732I,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,P139T,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A243N,L244-,H245-,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,G482S,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A845V,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,Q1071K,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 10 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,D253E,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,I203L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 18 +[S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,N658D,P681R,S939F,P1143L,E1150D]-[T19I,L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 14 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1129I,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I931V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,D1146H]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 17 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S373P,S375F,T376A,D405N,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L,G1219C]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 5 +[+16MPLF,R21T,S50L,L56V,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 11 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,N394D,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,R34L,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 2 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,A626V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681-,+683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,G184A,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 9 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,T1117I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 6 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,H146K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1157N]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A684V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,G72E,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N185K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N188S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,A475V,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 0/2 0.00000/0.00018 +0.02% +100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,M177T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 2/0 0.00018/0.00000 -0.02% -100.0% 2e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G184D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,Q836L,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 2 0.0% 1/1 0.00009/0.00009 -0.00% -1.4% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,H655F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,H655Y,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,V622-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G252D,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S50L,F59L,H69S,S71-,G72-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1176F,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1254F,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A688V,S704L,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,I197V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486L,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V407I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L,V1177I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69Y,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,N1178Y,L1203F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,D979E,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,V1122L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 47 +[Q52H,H146K,F456L,V595I,S640P,V656I,V1133I]-[H146Q] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[L5F,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21-,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Y660R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,L179R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,K113T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,E702D,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[L18F,+18I,R21-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,F1103L,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N641T,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681-,+683Q,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,G184A,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T284I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T547I,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S929I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V952F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,D1118E,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,T1273I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,R1185H]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,K182T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[R21-,+22I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211T,L212G,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,F306L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N185Y,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,I1114T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,G35S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L,D1168G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,Q613H,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S689T,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T747I,S939F,K1086R,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,F377L,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,K462R,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,G504D,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A831V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,D1260Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F,P1143L,E1150D,D1168N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,T1273I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,K147I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,I1130T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[R21-,+22N,N30I,S31-,F32-,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T732I,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,L1224F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,S939F,V1104L,P1143L,G1251V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,L1203F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P812S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S50L,H69-,V70-,G72E,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q675H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 13 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A879T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N501Y,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N148T,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[R21T,S31-,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A924S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,E154Q,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1162T]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,N17-,L18-,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E516G,E554K,A570V,P621S,P681R,P812S,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T859A,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Y170H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S31-,S50L,H69-,V70-,T109I,L110-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21-,+22N,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,Y453F,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K150I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S31-,S50L,H69Y,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,T638I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[R21T,S50L,I68T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,V705I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,G257V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,W152G,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,T500S,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1070V,A1087S,P1143L,C1247F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,I651V,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,I434T,N439K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,Y248H,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,Y453F,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,D467E,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,F186S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,T478R,N481K,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 15 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456V,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S373P,S375F,T376A,D405N,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456V,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,S373P,S375F,T376A,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,F186S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456V,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S373P,S375F,T376A,D405N,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 16 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456V,E554K,A570V,P621S,P681-,+683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S373P,S375F,T376A,D405N,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 16 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456V,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S373P,S375F,T376A,D405N,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S373P,S375F,T376A,D405N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L,Q1201L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,F592S,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D,S1252F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,N30D,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F490L,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,I1132T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237W,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,F186S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,I68M,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,R190K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A684V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,D985G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554N,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264A]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,S60P,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[P9S,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R357I,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,D1199Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,P384S,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,N824S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,L841F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,A67S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255P,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,G482D,V483-,E484K,E554K,A570V,P621S,Q677L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681-,+683W,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N188D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,E918A,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H,N764K] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,V1104I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A871V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T274I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,T1273I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,Q804K,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A684T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,S1252P]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,N679-,+681SKS,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,+19I,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,W64R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1045T,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69F,V70-,S71-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,Q314R,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S375F,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A706V,S939F,N960S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 35 +[S50L,F59S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,N481K,E554K,A570V,P621S,V642A,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,S371F,S373P,S375F,T376A,N440K,V445P,G446S,N460K,S477N,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,E1150D,C1236F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,F515L,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 47 +[T29N,T51I,Q52H,F157L,L455F,F456L,K462T,T470N,N481K,T572I] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N501Y,Y505H,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,D1139G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1201H]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,D1168Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N196S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S640Y,N641-,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[+16MPLF,R21T,Y28H,S50L,H69-,V70-,V127F,F157S,R158G,G184A,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,E654K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,T19R,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L,C1247F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,L585F,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,N603S,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G252D,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,G72W,V127F,F157S,R158G,V159F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q173R,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G252D,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,D614G,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,P272L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,P174T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,N30I,S31-,F32-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,S60F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,E661Q,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,V860L,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,G72R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,T284I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[L5F,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S937T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1228L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,F32-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A892V,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,L84Q,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D745G,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683L,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A263S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 23 +[N17M,+18I,+20C,T22C,Q23L,+23*,P25Q,P26T,A27Q,+27S,S50L,A67V,H69-,V70-,D88G,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,T29I,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N960S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,G75S,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A688V,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S691F,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A846V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,R273S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,T478E,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K147I,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31P,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T284I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683L,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,R273G,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,I1210L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,R34L,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,P521R,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,I670V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,N540K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E484K,F486L,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D745G,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255Y,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[Q14H,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,Q1113K,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A846S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,G268C,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,L296P,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,G72E,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S31-,S50L,I68T,H69-,V70-,V127F,M153I,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481R,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,G35R,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,K150I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G261R,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,I1114T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D936E,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I934V,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,C1248F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,D1084G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,T33P,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q173K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N185S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T638I,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16IPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,S371F,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642G,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,V327I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21-,+22N,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,R34L,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q173H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,F59S,W64R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,W886L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 14 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,T33I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A262V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N501Y,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S371F,S373P,S375F,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G261S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,M740I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 13 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T719I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1133I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[V6A,+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,D215H,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T768A,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,L822F,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[L5F,+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452R,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,A27-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S640F,P681R,A871S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,S151R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,D198E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N137K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21-,+22I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621-,V622-,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A879V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T638I,P681R,S939F,V1104L,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21-,+22N,S31F,T33I,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,+19I,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,H1083Y,V1104L,P1143L,K1191N]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,P174S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,G1219C]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,F58S,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,A292T,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,E309Q,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,Y269H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N532S,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P793S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,T108I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q239R,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S50L,F59S,H69-,V70-,V90A,V127F,F157S,R158G,N211-,L212I,V213G,L216F,P217S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N1125S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[L5F,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,P217S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486S,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,V42I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V952F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,N30Y,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,P499H,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,K558N,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,G35R,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N164H,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A879S,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,D614S,P621S,P681R,S939F,P1143L,M1237I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,D614G,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G261C,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1020S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T747I,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T883I,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,M1237I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,F59I,H69-,V70-,G75V,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,N764K] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16TPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1228L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,+211G,V213-,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,Y369D,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,S680F,P681R,S939F,S940F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V159I,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,L828F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[R21T,S31-,S50L,H69S,S71-,G72-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T676N,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,G72R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,T961A,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 13 +[N17M,+17P,+18FNFI,R21-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+682L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,N532S,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N501Y,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69F,V70-,S71-,V127F,S151I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681-,+683Q,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,D80Y,V127F,F157S,R158G,P174S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S689N,S939F,P1143L,D1260Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,V308L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1260Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,P230S,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,L84V,V127F,F157S,R158G,Q173K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445Y,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L,D1146H]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,W64C,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A879V,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A899V,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,D1084E,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,+374F,T376-,R403K,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S375F,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T961M,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G252S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,H625Q,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,F32-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445Y,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,Q1005H,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,K187S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,G35R,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21-,+22I,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,A1020S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,V635A,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,A344V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339Y,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I805V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,G446I,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21-,+22N,S31F,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,I101M,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K304Q,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,L752F,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q675H,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H,D796Y] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,A397V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,Y508H,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,I402V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,G219D,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1176F]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681-,+683L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,H69-,V70-,G72E,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,G75D,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,K558N,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A688V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,V1268I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642A,P681R,N856S,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[R21T,L24S,P25T,P26Q,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N148Y,F157S,R158G,M177I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,R346K,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 46 +[Q52H,F157L,T385I,L452R,F456L]-[T19I,G339H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,+482K,E484P,G485-,F486-,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S689T,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q675K,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T274I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,A27-,S31P,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S810L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,S940F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677P,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,T1273I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,L54F,H69F,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,L176F,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,M153R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,K558N,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V83F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[S12Y,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,E309Q,I332V,K356T,A397V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21I,S50L,H69-,V70-,V127F,F157S,R158G,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V90A,V127F,F157S,R158G,N211-,L212I,V213G,L216F,P217S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N1125S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K147E,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H66N,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,K41R,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,+19I,R21-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,S155I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681-,+683W,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157L,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,S477D,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,S477N,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A879S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,E1207D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A942V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,V687L,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547I,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A871S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,L56V,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,I670L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T1027S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[+16MPLF,S50L,F59S,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[+16MPLF,S50L,H69F,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A701T,S939F,P1143L,E1150D]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[R21T,S50L,H69-,V70-,+126F,I128-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,N1187Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157L,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,T33A,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,K535T,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,S1252P]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,T29I,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K150N,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D,D1168Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,K41N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A845S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P807S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,R273S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642G,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T1009I,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,G35V,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,T638I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258C,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,D111N,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q239R,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T547K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[L5F,R21T,S31-,S50L,H69-,V70-,V127F,W152R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,N1178D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 14 +[N17M,+17P,+18FNFI,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,R765L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,D111N,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,K304N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,P85R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S704L,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L,V1228L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,K1086R,V1104L,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211I,L212R,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,A163V,Q173K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q173K,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,V503I,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,M731I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,H49Y,S50L,H69-,V70-,V127F,F157S,R158G,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,E154K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,I844T,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441F,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A829T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L]-[L24-,P25-,P26-,A27S,V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L293F,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P681R,S939F,V1104L,V1122M,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478R,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1128I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T912K,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,L864F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,G482-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q218R,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F,V1268I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,G75R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1122L,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,D950V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A701V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486H,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,W152R,F157S,R158G,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,F186S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T1117I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T1117I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,K147-,N149-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[+16MPLF,R21T,S31-,V42I,S50L,H69-,V70-,P85S,V127F,F157S,R158G,V171I,S205F,N211-,L212I,V213G,L216F,H245N,A264D,R273K,I332V,K356T,T385I,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,Q949L,P1143L,A1226V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,G482-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A958S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,Y396F,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N960S,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[P9L,+16MPLF,R21T,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,I358V,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D745G,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[P9L,+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,I358V,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,E654Q,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F140L,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,A288S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S31-,H69-,V70-,G72R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69F,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,C1248F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,K147E,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q173R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,+482K,E484P,G485-,F486-,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,Q1113K,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,P272S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,S943G,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A852V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,D111N,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q218H,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T547I,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,V1129I,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q218H,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D936N,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,L461I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T676I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,+209F,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R765C,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,M177I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642G,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,D1259Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,R190K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[V6I,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,N30K,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I692F,I934V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V622A,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P793S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475S,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P793T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S698L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D796H,S939F,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,A93S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,N394S,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681-,+683L,S939F,V1104L,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P812L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,K150I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,H1058N,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[L8F,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A684S,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,K150I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,F559L,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V622A,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,+147K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,D1163V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,L1200F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L,L1200F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A879V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,P39F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1247F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,N501F,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N501Y,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,A647V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,V736L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[L5F,+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L,D1260Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,V171F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N148T,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,P139S,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T638A,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,A243N,L244-,H245-,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,P209H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,P85Q,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,E156D,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T259R,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,R1091H,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,G35R,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,S494P,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S704L,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257D,A264D,I332V,R346K,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,V193L,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,D215G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21-,+22N,G35R,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,T33I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,L110-,D111-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,A522V,E554K,A570V,P621S,P681R,K854R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,E1202Q]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[V11F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445Y,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L,C1235F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1229I,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A930V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T415A,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,S1252F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31F,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,E1092K,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,G594D,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,R78S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,T678S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,F32S,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T299I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486L,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A845S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N501Y,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 17 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,S477N,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 14 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,T33P,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 14 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 19 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S371F,S373P,S375F,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 19 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,T961M,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1228L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,F92V,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,E1072D,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21-,+22N,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,G798S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[L8F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,L1200F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,A123V,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,N556S,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,V42F,L48S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681-,+683W,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S640F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,S943I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,A352S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,A67V,H69-,V70-,V127F,F157S,R158G,G184D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,P809S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,E96A,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,W886L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,G1124V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N148T,F157S,R158G,K182R,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,F65Y,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,M177I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,G72R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,M177-,D178-,L179-,E180-,G181-,K182-,Q183-,G184-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+682L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I844V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 14 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,M177-,D178-,L179-,E180-,G181-,K182-,Q183-,G184-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+682L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,T29I,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,D215G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21-,+22I,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H,N764K] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,Y269H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,R634L,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264Y,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[V11I,+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,G1219S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,F643-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H,N764K] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H,N764K] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680Y,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,H69-,V70-,G72E,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H,Q954H,N969K] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,G1167S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,D80G,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,H146-,F157S,R158G,S205F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S371F,S373P,S375F,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 13 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D936H,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,S438P,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[L5F,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69F,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A871S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,N603S,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,H146K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,G946R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 59 +[P9L,N17I,L18-,T20-,H69-,V70-,S98F,P139S,V143-,Y145-,K147N,L212S,V213G,R214L,G339D,K417T,+444A,G447-,L452R,Y453F,F486A,N501F,N556K,P631S,A688V,E1195Q]-[T19I,V83A,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,R408S,K417N,V445P,G446S,N460K,T478K,F486P,F490S,N501Y] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,N282K,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A262S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T676I,P681R,S939F,P1143L,M1233T]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,D88H,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,G1167R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,A27-,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1078T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,D53N,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69P,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 14 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q173E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,E554K,A570V,P621S,P681R,S939F,D950E,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N641I,V642-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,D1084N,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,R237S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A831T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478R,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,K535T,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 13 +[R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,I1018M,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,L752F,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLL,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q675K,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T547I,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S704L,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,Q52H,W64R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680-,+683R,S939F,K1086R,V1104L,P1143L,K1245R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,H1083Y,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,N487D,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1040A,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,+215F,P217-,H245N,T250N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,I1225T]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,L585F,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A845S,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,P479S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,F32-,S50L,W64R,H69-,V70-,V127F,F157S,R158G,K202N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[V16I,+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,P174S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939L,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,Q134L,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,G446S,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,G1246C]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,T500A,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 50 +[V126A,I210T,R214H,P272L,T274N,L455F,F456L,A475V,M1229I,C1236F] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,S375F,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q675H,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A243N,L244-,H245-,L249F,A264D,I332V,A352V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,S60P,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D936Y,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G252S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,V772I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,T29I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,N556K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 17 +[N17M,+17P,+18FNFI,R21-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190M,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,E309D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,D1260E]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,L176F,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P807S,S939L,A1070E,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K147E,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,L84V,V127F,F157S,R158G,Q173K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1096I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,D574N,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,C1247S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,G594S,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,G1251R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,K444N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,K97T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V407I,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V90F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L189P,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,Y1155H]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,T1117I,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[N17M,+17P,+18FNFI,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,G482D,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G184A,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,G1219V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,I670M,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T1009I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,G72E,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,A123V,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,+681SQS,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,+215F,P217-,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T632N,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P728T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,A27-,S50L,L56V,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,K113N,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,Q23K,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181A,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,L1186I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,V622F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,N334K,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,G35R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,I68T,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,F186S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,F186S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680Y,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K147-,N149-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,V193L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,E96Q,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T1006A,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680Y,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V952I,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A262V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,H625R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I794T,S929T,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,W152R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1262D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,H1101Y,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[V16F,+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A522V,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,H1058Y,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,T33I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T859I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,Q607E,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T761K,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1208H]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,K150I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T887I,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T547I,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,D950N,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1247F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V83F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,D1146V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16LPLF,R21T,S31-,S50L,H69-,V70-,R78K,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,P272S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D,I1216M]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,+266Y,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K147E,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,K529T,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[F2L,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,E340K,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1137I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445Y,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D820N,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,E96K,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,S477K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T547I,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A684S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,G35R,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T778I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,G482-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455A,N481K,V483-,E484K,T547K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260G,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,T478E,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,T76I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Y200H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,N30D,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,P209L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,S940F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A688V,S704L,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,R78M,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1241F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,G72R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,G184D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1254F,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A942V,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 34 +[S50L,F59S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,E554K,A570V,P621S,V642A,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,S373P,K417N,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 35 +[S50L,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,E554K,A570V,P621S,Q677R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,S371F,S373P,S375F,T376A,K417N,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 33 +[S50L,F59S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,E554K,A570V,P621S,V642A,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,K795R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,M1233V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1020V,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P793S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P812L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,V42I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,D571G,P621S,T645I,P681R,A688V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,T29N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,R78K,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MSLF,R21T,S31-,S50L,H69-,V70-,E96D,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D936Y,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,A352S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D808N,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,N17-,L18-,R21-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,H1101Y,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,F186L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,Q613H,P621S,P681R,S939F,K1086R,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,H49Y,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V407I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,G1219V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441F,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 14 +[R21T,Y28H,S50L,H69-,V70-,V127F,F157S,R158G,G184A,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 17 +[N17M,+17P,+18FNFI,R21-,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,G72W,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240N,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S640F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,L179H,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,A67G,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,G946E,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S640Y,N641-,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264Y,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,V289L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,I100L,V127F,F157S,R158G,K182N,F192I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,L455S,F456L,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,I68-,H69-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478Q,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478Q,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S50L,H69-,V70-,L84V,V127F,F157S,R158G,Q173K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L455S,F456L,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S373P,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S673T,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[L5F,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,M177I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,T63I,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,V503I,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,T63I,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Y489H,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S50L,F59S,H69-,V70-,S98F,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,E1092D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,N440K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,F175L,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680Y,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S50L,H69-,V70-,T73I,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,Q690P,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,P561H,A570V,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,N137K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P793S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,A1020S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,S940F,V1104L,I1114T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,Y204H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,+374F,T376-,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S375F,T376A,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,P85S,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339D,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,G339H,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,P521S,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,L176F,Q183H,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486L,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,R273S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,D111N,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31P,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478R,N481K,V483-,E484K,E554K,A570V,P621S,N641S,P681-,+683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,E780D,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K150R,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185M,F186-,K187-,N188-,L189-,R190-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,T1027N,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486L,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G184D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A899S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T274A,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,A222T,H245N,A264D,I332V,K356T,R403K,L441I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185M,F186-,K187-,N188-,L189-,R190-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D936H,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1162T]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I934V,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,S940F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,D80Y,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T732I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I834V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,S494P,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,S494P,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,T1231I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31F,V36I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A262V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,A123V,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,V42F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,L54F,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A522S,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D936H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,+344S,R346-,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V976F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,V503I,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,T109I,L110-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,A845V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,I670V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,P793S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,G72W,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,P57S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,R1014K,I1114T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,E224Q,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,A647S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 52 +[S151I,G181A,V367F,N440R,Q613H,A623-,I624-,V642G,E1144D]-[N440K] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,F59S,H69-,V70-,R78M,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,K1086R,V1104L,P1143L,K1245R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,A575S,P621S,P681R,L822F,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,F32S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,T33S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,G1219S,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,+209V,N211G,L212-,V213-,L216F,H245N,A264D,T307I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,N1187S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I726V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,P330L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P809L,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S31-,S50L,H69-,V70-,V127F,F140L,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,D745G,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,A344S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N148T,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,G1267V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,S939F,V1104L,P1143L,G1251V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,L54F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,E554K,A570V,P621S,Q677R,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I794L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[S12F,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,R765L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69F,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,N657D,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,G1124V,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V193L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+19I,R21-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D745G,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,E484A,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,G476-,T478N,+478K,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D,D1163G]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,S477N,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642G,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[L5F,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,T33K,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T1117A,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 81 +[P9L,K77E,T95I,C136-,N137-,D138-,P139-,F140-,G142-,V143-,Y145-,H146-,K147-,N148-,N149-,K150-,S151-,W152-,M153-,R158K,D215G,L244-,H245-,R246-,Y248-,L249-,T250-,P251-,D253-,S254-,S255-,S256-,G257-,I332V,G339D,E340K,K356T,R403K,K417T,N440R,K444R,L452R,T478I,E484-,S494P,G496S,V615A,V642G,P681R,A688V,G838S,L841R,D936H,S939F,E1150K]-[V83A,G142D,H146Q,G252V,G339H,L368I,K417N,N440K,V445P,G446S,N460K,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478R,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,T33A,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31P,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S640F,V642G,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,H1088R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,T95S,A123V,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69F,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,G639D,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,E281A,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A243S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,S940F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,Q836H,Y837-,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,I1115V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I844V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S371F,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,P809Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,T259I,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,T51I,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260G,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,D745A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69A,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S884A,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A829S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1189I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,H1101R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,E340Q,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 14 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,P251L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 16 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T274I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 16 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I850V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[S50L,H69-,V70-,V127F,F157S,R158G,P174S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[S50L,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 17 +[S50L,F59S,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[S50L,H69-,V70-,V127F,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,N1178S]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 16 +[S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,+215F,P217-,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 13 +[S50L,F59S,H69-,V70-,V127F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 15 +[S50L,H69-,V70-,V127F,R158G,N211-,L212I,V213G,L216F,H245N,A264D,N317S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 15 +[S50L,H69-,V70-,V127F,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 14 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I742V,S939F,E1092D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,E1150D]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 18 +[S50L,H69-,V70-,V127F,K187R,N211-,L212I,V213G,+215F,P217-,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 17 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,F59S,H69-,V70-,V127F,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 16 +[S50L,F59S,H69-,V70-,V127F,W152L,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,A1087S,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 74 +[V3G,L5F,F157S,S255F,Y449S,T573I,I624M,T859N,D985N,K1149R]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,Q498R,Y505H,H655Y,N679K,N764K,D796Y,Q954H,N969K] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 78 +[V3G,L5F,A67-,I68-,H69-,D215G,R246G,S255F,G261S,Y449S,F490L,T573I,I624M,T859N,D985N,K1149R]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445P,G446S,N460K,S477N,T478K,F486P,F490S,Q498R,Y505H,H655Y,N679K,N764K,D796Y,Q954H,N969K] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,M153K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K300R,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,Q1002H,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,V615I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 14 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,S940F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,D614G,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,F59-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486L,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,K182I,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[Q14R,R21T,S31-,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K304N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T284I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T961M,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31Y,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T874I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,Y38-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1168E]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A262V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,Q675R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31P,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,N30D,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,V826L,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,G35R,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101V,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,R1107K,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,E154Q,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1208H]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V622A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,G932C,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,V656I,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,K147E,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Y660R,P681R,A871S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,S254F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,A1078T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,M177I,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,E1092D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486L,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F486P,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,T29I,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,I1130V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,T345S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A771S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,R190S,N211I,+211G,V213-,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L,D1163Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,N30D,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,A575S,P621S,P681R,S939F,K1086R,V1104L,P1143L,R1185H]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,N856S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T573I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185S,F186-,K187-,N188-,L189-,R190-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346S,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1122L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A893V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A942S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,N30D,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,I68T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,A1226S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31F,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,V826L,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,N354K,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,N30I,S31-,F32-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,F32-,S50L,W64R,H69-,V70-,G72E,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,R408G,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,Y269F,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,+58L,S60-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258R,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T723I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,Q1201L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,T307I,I332V,A352S,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,T29I,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,R273S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642A,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21-,+22N,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L,S1252F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D808N,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,H69-,V70-,L84I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475T,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P793S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,G476-,T478N,+478K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,S477N,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 52 +[P9L,H69-,V70-,T95I,P139S,H146K,N148T,N185D,R214S,G339R,R403K,N440R,K444N,V445T,G446R,N481K,F486H,S704L,M740T,V1129I]-[H146Q,G339H,N440K,V445P,G446S,F486P,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1208Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,K558N,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,H1088Y,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,H69-,V70-,G72E,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,P272L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I805V,S939F,S940F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,A831V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,W64L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,P809S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L,D1260Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,T1117I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T761A,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,G639A,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,F32-,S50L,W64R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Y1155H]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,E1092D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,A575S,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K150R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,P39L,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,I1225T]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,R34S,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,E96Q,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N532Y,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69P,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D936Y,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,D111N,V127F,H146K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,S943G,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,G72E,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,+126F,I128-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493A,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,Q1113H,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,T29I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,K921R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,G446T,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,D1260Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[L5F,+16MPLF,R21T,F32-,S50L,W64R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,Q1071H,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A879V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642A,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,C1235F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264Y,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E471Q,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S375F,T376A,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T1136P,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,H49Y,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,P681R,S939F,V1104L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,Y636-,S637-,T638-,G639-,S640-,N641-,V642-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V90F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T299I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[Q52H,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S31-,R34C,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,F1156L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,+266Y,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D745A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,I1114T,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,F65S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,G476-,T478N,+478K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,T33I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,H146K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S31-,S50L,H69-,V70-,V127F,N148T,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,I1225V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,+209T,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21-,+22N,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P809L,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R357I,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,M153K,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,S155I,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190S,N211-,L212I,V213G,L216F,E224Q,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,D138H,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,T29I,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,Q321L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,K147E,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,T76I,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q239R,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V622A,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,E1202Q,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,W64R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,E1150V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,S477K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,S477N,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,M177I,N211-,L212I,V213G,L216F,H245N,A264D,E309K,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,Q836E,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,P39S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,H1058Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,V445H,N450D,L452W,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,L1200I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,N641I,V642-,P681R,L699I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,E96D,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A846V,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T547K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,G72E,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A831V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A845V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,D80Y,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,G35R,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N185S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 48 +[Q14H,Q52H,K147N,D253G,S256L,V445L,F456L,S494P]-[V445P] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1176F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,G639S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N185S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212W,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,G639A,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,G72R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,K147E,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,L56V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,W152L,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[+16MPLF,R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,G744D,S939F,P1143L,I1169T]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+682W,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,G482S,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,H1101N,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,P251L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E554K,A570V,P621S,V622A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484-,G485-,F486-,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Y144-,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A846V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21-,+22N,V47L,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1237I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,H69-,V70-,S112P,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,+32S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S637F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,P174S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,D1127G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S750G,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,M153V,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680Y,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,A1174V]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,L84I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21-,+22N,S31F,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,Q613E,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A684V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S691F,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[Q14H,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,I197V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,E748Q,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,D88N,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260D,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I850T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Y160H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,S494P,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,E96G,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,P337S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,A623-,I624-,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157L,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,Q690K,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D936H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S689N,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,L865H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N1023S,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P809S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,H1058Y,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,H1101Y,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G261V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,S205F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,A668S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,M902I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,K558N,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,Y1110H,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,D215H,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S640F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A262V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486H,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,G35C,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P812L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,N148Y,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T1117I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,T1009I,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681-,+683L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,D1259E]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,H1101D,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,N556K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T719I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677L,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,N1187D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q173E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,N30K,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I692F,I934V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31P,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,P217S,H245N,A264D,I332V,K356T,+374F,T376-,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N960D,N1125S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,D80Y,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,Q239R,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V120F,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q675K,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,D88N,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,M153R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,S1196F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S929I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,D290E,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 44 +[E554K,T618I]-[N460K] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,S98F,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[R21T,P39L,S50L,H69-,V70-,V127F,M153I,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,K854N,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,V642F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,E1150Q]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,E1195Q]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 49 +[T19L,E180A,K304N,T307I,R408N,T478R]-[T19I,R408S,T478K] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,+374F,T376-,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1128I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,T376A,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,V785A,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N164H,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A879S,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,P85Q,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T676A,S680F,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1233I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,A352N,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P807L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,G1219C]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L,K1154E]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1236F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212W,V213-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A243S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183P,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T732I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[P9S,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,A668T,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,M731I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,K854N,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D936Y,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,R21-,+22N,S50L,F58L,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,F486S,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,N460K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,R34P,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1230L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,N148S,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,F32-,S50L,W64R,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,F565L,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D808V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[R21T,S31-,S50L,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,G446T,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P809S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S50L,S60P,W64L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[R21T,S31-,S50L,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 11 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181V,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 13 +[R21T,S31-,S50L,H69-,V70-,G75V,V127F,F157S,R158G,Q183H,R190T,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S31-,S50L,H69-,V70-,G75D,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1060I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,K150E,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,P812L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1240W]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,P479L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,A163V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,D80Y,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,L1197F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 18 +[N17M,+17P,+18FNFI,R21-,N30I,S31-,F32-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A845S,S939F,V1104L,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S640F,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R765H,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H66R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V622-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T734I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,E748Q,S939F,H1083Y,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I794T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,Q779L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 45 +[G184V,D253G,P521S]-[G252V] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,D1139Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,G1219V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,K147I,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,T33A,S50L,H69-,V70-,K97N,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,R237M,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[N17M,+17P,+18FNFI,R21-,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,D1259V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,G476-,T478N,+478K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S477N,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16KPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T500A,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,N87K,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,V1164I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T732I,A845S,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681-,+683W,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21-,+22N,S31F,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69Y,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A243S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,G842S,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[L8F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,Y508H,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S50L,H69-,V70-,V127F,K150R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,Y145N,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,D287G,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,N928S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 48 +[G181A,V367F,Q613H,V642G,E1144D] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[L5F,R21T,S50L,A67V,H69-,V70-,V127F,S151I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S50L,A67V,H69-,V70-,V127F,S151I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,F59L,H69-,V70-,V127F,S155I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680Y,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,G35S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,E1144Q]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483R,E484-,E554K,A570V,P621S,P681R,P812L,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S691T,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A892V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 18 +[N17M,+17P,+18FNFI,R21-,S31P,S50L,F58Y,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q239R,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,L585F,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,Q613H,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 13 +[R21T,S50L,H69-,V70-,V127F,F157S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,K921R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,E1151D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,G482D,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,Q1113K,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,S940F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I934V,S939F,A1078T,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,T1273I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,T19L,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,I624M,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,L118F,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,D1127G,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[F2L,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681-,+683W,D843G,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,G381R,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,P337S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,S940F,A1070E,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,D178N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,Y269H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,K182R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A846V,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D820E,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,N703I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,G35V,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P862R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[L8F,+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,S477K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,+19I,R21-,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1247F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,I1183V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,Q52H,F59-,+60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I834V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,P499S,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,S1242G]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A684T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,K1086R,V1104L,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K150R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1235S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,N1125D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,R408S,V445P,G446S,N460K,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,I100M,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A942V,V1104L,P1143L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A684V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,R190S,N211-,L212I,V213G,L216F,H245N,W258C,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,H207Y,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678I,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,N334K,K356T,R403K,V445H,N450D,L452W,L455S,A475V,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G181R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339R,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,G339H,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,I410V,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,A845S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,G268S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,W152L,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[L5F,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69S,S71-,G72-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1070S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S735L,K854R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211T,L212G,V213-,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,C1236F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,R273S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,L754F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,V622-,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T259S,A264D,I332V,K356T,+374F,T376-,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S375F,T376A,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S45F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,A626V,P681R,D936H,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A879S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 15 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V83F,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,P85L,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,E180D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1191N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,P85Q,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,S205F,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21T,N30I,S31-,F32-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1070V,K1086R,V1104L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,R765L,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,I670M,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,K814R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T719S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[L8F,+16MPLF,R21T,S31P,S50L,F58Y,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,F65Y,H69-,V70-,V127F,F157S,R158G,Q183P,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,I434V,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E554K,A570V,P621S,T676A,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E554K,A570V,P621S,S680Y,P681R,S939F,P1143L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,H1058Y,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[L24-,P25-,P26-,A27S,V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T732I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1129L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 70 +[P9L,T20I,A67V,H69-,V70-,T95I,C136F,V143-,Y145-,S151-,W152-,L176F,N211-,L212I,+214EPE,I231T,G339D,R346K,N354K,S371L,P384A,K417T,V445A,F486V,G496S,T547K,V772D,N856K,L981F,P1079S,P1162L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,S371F,T376A,D405N,R408S,K417N,V445P,N460K,F486P] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[F2L,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,G142N,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441V,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A879T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,F59S,W64R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,G566S,A570V,P621S,R646F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K150E,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 44 +[H69-,V70-,V213G,D253G,T299I,G339Y,N440R,K444T,L452R,F486V,T572I,I666V,S982L,E1195Q]-[V83A,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,N440K,V445P,G446S,F486P,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21-,L48F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478R,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,V1104L,P1143L,L1244F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,L1244I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,Q52R,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,P272T,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[L5F,+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,Q677L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A766S,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,K147E,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A766S,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,F186L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,E309Q,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,V615F,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 44 +[T76I,L455F,F456L,S704L] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,P272L,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 64 +[Q14H,H69Y,V70-,S71-,W152R,F157S,K187E,H207R,V213A,+213GG,G257D,A348P,N354K,K356Q,R403K,N440R,V445A,Y449N,L452R,T478R,Q493R,G496S,K529N,T547K,A570V,A575S,N606D,I651V,Q675H,N679R,S691Y,R765S,A942S,S1147L,I1216T]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182E,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V90I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,T73A,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 17 +[N17M,+17P,T19F,T20N,R21F,+21I,Q23T,L24N,P25Q,S31F,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,L24-,P25-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21-,+22N,S31F,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,D1184Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,T29N,S50L,H69-,V70-,V127F,F157S,R158G,G181R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,S494P,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,K814R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,T95I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V642F,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D936Y,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,H69-,V70-,V127F,F157S,R158G,Q173K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,V642F,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,G482-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,I1210T]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21-,+22I,H49Y,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,T29N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,G1085R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,R34C,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1078S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31P,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681-,+683W,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[L5F,+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452R,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A771V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A831V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,P57S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,R34C,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A899S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MLLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S50L,H69-,V70-,R78K,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,T478E,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681-,+683Q,D745G,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,D839N,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1078S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,L84I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,F643-,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,H1271Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P809S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,L1203F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P809Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,K558N,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,L293F,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,S60F,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,L118F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,W152R,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q173R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,W152L,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[L5F,+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P792L,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,H207Y,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,D1084Y,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N501Y,Y505H,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,T678-,+679K,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S371F,S373P,S375F,T376A,V445P,E484A,F490S,N501Y,Y505H,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21-,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[P9S,Q14P,C15L,V16F,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 23 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 17 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E554K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D,D1184N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,H1101Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[N17M,+17P,+18FI,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,Y449D,N450-,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,Q134L,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,G1099S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 15 +[+16MPLF,R21T,S50L,H69-,V70-,A123V,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,L56V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,I670L,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[N17M,+17P,+18FNFI,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S254F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,G1085A,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L,I1183L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,D111N,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[L8F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,G446S,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,G476-,T478N,+478K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,I197V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T732A,S939F,P1143L,P1162S]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,S477N,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,G504D,E554K,A570V,P621S,P681R,S939F,P1143L,E1182D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,N440R,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,D1127N,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,T29I,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,L585F,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,Y1155F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478R,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,V622A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G261R,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,F59V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,D88N,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,D1260Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[Q14R,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,P812L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,P85S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,H625R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S31-,S50L,F59-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,Y837H,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,W1102L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1045T,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[V3F,+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,L822F,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,V503I,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,D950N,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A892V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T284I,I332V,K356T,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,I624M,P681R,A845V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1096I,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,P330S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 16 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 16 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 16 +[V47F,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,E1092D,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[L5F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,A1087S,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,P337S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,P174L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,Y789H,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1237T]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,Y789H,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,K150E,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31-,S50L,H69-,V70-,P85R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,Y453F,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483K,G485P,F486-,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,N1187K]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G261V,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,Y453F,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1237T]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,M153T,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T547I,E554K,A570V,P621S,T676I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G261V,A264D,I332V,K356T,R403K,K444R,V445H,N450D,L452W,Y453F,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,Y505H,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,F1075L,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A262V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,I870T,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,V36I,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,E748Q,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,H625Q,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,V1104L,P1143L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,Q580L,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260T,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[L5F,+16MPLF,R21T,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,M740I,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,E554K,A570V,P621S,P681R,S939F,P1143L,L1200F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S373P,S375F,T376A,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 13 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S373P,S375F,T376A,D405N,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S373P,S375F,T376A,D405N,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 16 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,M177I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S373P,S375F,T376A,D405N,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 16 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S373P,S375F,T376A,D405N,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 16 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S373P,S375F,T376A,D405N,V445P,S477N,T478K,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,P85S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211I,L212G,V213H,R214-,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,Y145L,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,P85R,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,E661D,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,Q613H,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[N17M,+17P,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16IPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21-,+22N,S31F,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A262V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T747I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,T33A,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,G482-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[+16MPLF,R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,Q173P,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,E340K,K356T,R403K,V445H,N450D,L452W,L455S,K462T,N481K,V483-,E484K,E554K,A570V,P621S,S680Y,P681R,N801D,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,K1086R,V1104L,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A892V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,S680A,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P812S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,R408G,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,+938F,T941-,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,F92L,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21-,+22N,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T547I,E554K,A570V,P621S,P681R,T747I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69F,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346I,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G184V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A852T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N501Y,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N501Y,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,I670M,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143F,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,S155G,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,G446T,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,G446S,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,T732I,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,E583D,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,P39T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,N556K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,D178Y,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,V503I,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,G946R,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,N30Y,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,I997V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 52 +[N137M,P139D,F140Q,L141-,G142-,V143-,Y145-,H146-,P384S,T430I]-[G142D,H146Q] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481R,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,P174S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,K558N,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T500-,+501Y,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N501Y,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,N148Y,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,F486S,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L,D1168N]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T500A,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPMF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 11 +[R21T,N30T,S31I,F32-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,F59L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[Q14R,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,I472T,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,F565L,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,L244S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T724I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,N556K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,P174L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,R634H,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S371F,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,S151I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,A623-,I624-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,A570V,P621S,P681R,S758I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,K529R,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,N460K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,N1192D,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,K77T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A243S,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,D1184H]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,+374F,T376-,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,S375F,T376A,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q644P,P681R,I844V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V407I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,G232V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,S112P,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,V620I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I834V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332A,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 9 +[R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P812R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 8 +[R21T,S31-,S50L,H69-,V70-,V127F,W152C,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 10 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[R21T,S50L,H69-,V70-,N87K,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[R21T,S31-,S50L,H69-,V70-,G72R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,F186L,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1229I]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D936E,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D936E,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21-,+22N,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250I,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486L,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,H146K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1157N]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681-,+683W,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N185T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,Q677K,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,N30K,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,I934V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T250N,A264D,P272H,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T573I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441V,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21I,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N137S,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,T478R,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A706V,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[L5F,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,P39L,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T573I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,K558R,A570V,P621S,P681R,S939F,S943N,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[P9S,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681-,+683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,T76I,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T791K,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K278E,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,S1239N]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Y170F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,G594S,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,E661D,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,V503I,E554K,A570V,P621S,P681R,V722I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481E,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621-,V622-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,T208S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A243V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,P1143L,G1251V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,I584V,P621S,P681R,S704L,P812S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,D215N,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A893V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,I584V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,G75R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 14 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V382L,R403K,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,S477N,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I850V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,Q954Y,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,Q954H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,V1129I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1202Q]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,M902V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,Q218R,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,F643-,Q677H,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,F1095L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D427N,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31F,S50L,H69-,V70-,V127F,K150I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,P337S,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,T29I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,F32S,S50L,H69-,V70-,V127F,F157S,R158G,L176F,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,P1263L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,V510I,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,D138H,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[V6A,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,F59V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680-,+683R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,I670M,N679M,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S689R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[L5F,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T778I,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,D936Y,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,Q1180R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,T478Q,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D,W1217L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S750N,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257C,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,K304N,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,K558N,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[L5F,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31P,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,F59S,H69F,V70-,S71-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,R34P,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[L5F,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T791K,S939F,V1104L,P1143L,D1168Y]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 16 +[N17M,+17P,+18FNI,R21-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[T19I,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,N148I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,D198G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,G932S,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,T240P,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,L141F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,K182I,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,G1124V,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1045T,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V362F,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,W258L,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[L5F,R21T,S50L,H69-,V70-,G75R,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,C1247S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 7 +[R21T,S50L,H69-,V70-,P85S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,A475V,N481K,V483-,E484K,E554K,A570V,P621S,E1188K]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1020S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,F58L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,M731I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,I1114T,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,E309Q,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,G257S,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,F92L,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,H146K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S813T,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,V705F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,G1171S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,H146-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[+16MPLF,R21-,+22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L,C1247F,D1260Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,K97T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,V642A,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,A288V,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,M731I,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,L56V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185I,F186-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,E340K,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,G35S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPVF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T284I,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,M177I,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q675K,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPVF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,Q218H,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S60P,W64L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S60P,W64L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1176F]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,R273S,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 12 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S680-,+683R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S31-,S50L,H69-,V70-,T73I,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,R237M,H245N,A264D,I332V,K356T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A845S,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,S940F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,G566S,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T696N,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,S60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,T259P,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,W152R,F157S,R158G,N185M,F186-,K187-,N188-,L189-,R190-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,Q1201K]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 12 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185M,F186-,K187-,N188-,L189-,R190-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,T1027N,P1143L,E1150D]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,A222T,H245N,A264D,I332V,K356T,R403K,L441I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,P39L,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,Y144C,Y145-,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 8 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,N960S,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 10 +[R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,A352S,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,L1203F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T385I,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,A67S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,A575S,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1078S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S31-,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T732I,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,A1078S,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 56 +[A67V,H69-,V70-,T95I,V143-,Y145-,N211-,L212I,+214EPE,G339D,R346K,S371L,Q493R,G496S,T547K,N856K,L981F]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,S371F,T376A,D405N,R408S,V445P,N460K,F486P,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356M,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,P85L,V127F,F157S,R158G,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,L84V,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59-,+60P,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,Q804K,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69F,V70-,S71-,V127F,F157S,R158G,Q183R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21-,+22N,S31F,S50L,H69-,V70-,V127F,M153I,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,P561H,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681-,+683W,S939F,V1104L,P1143L,C1253F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[L5F,+16MPLF,R21T,N30T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,T549I,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[Q14R,+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,R190K,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V362I,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I818V,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,P39S,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L,Q1208H]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,P561H,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,T33I,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681-,+683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,A27-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,E340Q,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,F456V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[P9L,+16MPLF,R21T,S50L,H69-,V70-,T95S,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,L922F,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 1 +[P9L,+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,R78S,L118F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,V1228A]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S50L,F59S,H69-,V70-,V127F,F157S,R158G,Q183R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,S943G,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 6 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,P85L,V127F,F157S,R158G,G181V,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,+126F,I128-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L,M1233T]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 2 +[+16MPLF,R21T,S50L,W64C,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,T430I,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K182N,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,K1086R,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,P384S,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,E554K,A570V,P621S,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,S477N,T478K,E484A,F490S,P681H,Q954H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16IPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,E1150D,R1185S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,D936H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,E1262G]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 4 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,V1104L,P1143L,P1162S]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,S98F,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 5 +[+16MPLF,R21T,S50L,F59L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,V1104L,P1143L,K1266R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 3 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 0/1 0.00000/0.00009 +0.01% +100.0% 1e+0 2 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1020V,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,H146K,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,K187R,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 9 +[+16MPLF,R21T,S50L,V62F,H69-,V70-,V127F,G142V,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,+374F,T376-,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,S375F,T376A,V445P,E484A,F490S] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,S31F,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,N440K,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,A570V,P621S,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 5 +[+16MPLF,R21T,S50L,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A260V,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21T,T33A,S50L,H69-,V70-,V127F,F157S,R158G,N185D,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 7 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,V127F,F157S,R158G,Q183H,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,E484A,F490S,P681H] N/A 22004 1 0.0% 1/0 0.00009/0.00000 -0.01% -100.0% 5e-1 6 +[+16MPLF,R21I,S50L,A67V,H69-,V70-,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,E484A,F490S,P681H]
last modified: Mon Jan 8 13:32 2024
GISAID data provided on this website is subject to GISAID's Terms and Conditions
Questions or comments? Contact us at seq-info@lanl.gov.
Questions or comments? Contact us at seq-info@lanl.gov.
