COVID-19 Viral Genome Analysis Pipeline
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Frequency Changes in Common Forms
Last update: Aug 10, 2026
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SPIKE sequences: Exhaustive list of Last 60 days, Global, Do not break out by lineage
Compute mutations relative to XBB.1.5 baseline sequence
As new lineages emerge, there are often many sequences with many ambiguous base calls. Our pipeline filters out such sequences, and as a consequence we undercount the number of sequences in GISAID that have been specified as members of related Pango lineages. Our strategy, however, enables us to use strictly high quality sequences to identify and track the common forms in emerging lineages.
COMMON FORMS CHANGES FOR SPIKE WITH A GIVEN PANGO LINEAGE DESIGNATION
For each lineage, we show the most common forms of SPIKE, and we show the forms that are most significantly increasing or decreasing. Also shown is the Hamming distance (HD) between each form and the most common form in that lineage. Deletions relative to the baseline reference strain are indicated with a dash (e.g. the two amino acid deletion at positions 156-157 is indicated with 'E156-,F157-'), and insertions are denoted by a plus sign (e.g. an extra T at position 143 is written '+143T'). Abs Differences in later vs early fractions, expressed as percent. Relative Differences range between -100% and +100%, using formula: rel = 100*(later-early)/max(later,early) percent, applied to the early and later fractions. The p-value associated with increase or decrease is computed by Fisher's exact test, and is meant to be used only as a rough guide to the significance of the change. Since the computation is based on assumptions (such as independent and unbiased sampling) that may not hold in practice, the p-value should not be taken too literally. The first line of each lineage section indicates counts for the full lineage relative to all the sequences. 'Lineage Count' in this first line is actually the full sequence count. 'Form Count' in this first line is actually the full lineage count, and 'Form Pct' refers to lineage count relative to full sequence set.
We show all the forms.
[Note: Mutation strings are relative to baseline XBB.1.5].
This output is based on 1401 sequences sampled from 2026-05-29 to 2026-07-28
This total interval is split into two sub-intervals.
Total: 2026-05-29 to 2026-07-28 (1401)
Early: 2026-05-29 to 2026-06-30 (690)
Later: 2026-07-01 to 2026-07-28 (711)
Baseline XBB.1.5: [T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,D614G,H655Y,N679K,P681H,N764K,D796Y,Q954H,N969K]
Pango Lineage Form Form Counts Fractions Differences Lineage Count Count Pct Early/Later Early/Later Abs Relative pval HD [Form as mutation string] N/A 1401 125 8.9% 50/75 0.07246/0.10549 +3.30% +31.3% 3e-2 0 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 61 4.4% 18/43 0.02609/0.06048 +3.44% +56.9% 2e-3 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 59 4.2% 23/36 0.03333/0.05063 +1.73% +34.2% 1e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 50 3.6% 2/48 0.00290/0.06751 +6.46% +95.7% <1e-10 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 40 2.9% 32/8 0.04638/0.01125 -3.51% -75.7% 8e-5 14 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 37 2.6% 28/9 0.04058/0.01266 -2.79% -68.8% 1e-3 83 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 24 1.7% 6/18 0.00870/0.02532 +1.66% +65.7% 2e-2 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 24 1.7% 11/13 0.01594/0.01828 +0.23% +12.8% 8e-1 16 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 23 1.6% 12/11 0.01739/0.01547 -0.19% -11.0% 8e-1 7 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 22 1.6% 13/9 0.01884/0.01266 -0.62% -32.8% 4e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 22 1.6% 19/3 0.02754/0.00422 -2.33% -84.7% 4e-4 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 21 1.5% 8/13 0.01159/0.01828 +0.67% +36.6% 4e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 19 1.4% 11/8 0.01594/0.01125 -0.47% -29.4% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 19 1.4% 3/16 0.00435/0.02250 +1.82% +80.7% 4e-3 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 18 1.3% 12/6 0.01739/0.00844 -0.90% -51.5% 2e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 1401 16 1.1% 9/7 0.01304/0.00985 -0.32% -24.5% 6e-1 27 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 14 1.0% 13/1 0.01884/0.00141 -1.74% -92.5% 8e-4 20 +[T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 13 0.9% 10/3 0.01449/0.00422 -1.03% -70.9% 5e-2 31 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 13 0.9% 13/0 0.01884/0.00000 -1.88% -100.0% 9e-5 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,I1221V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 12 0.9% 7/5 0.01014/0.00703 -0.31% -30.7% 6e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1401 12 0.9% 5/7 0.00725/0.00985 +0.26% +26.4% 8e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 12 0.9% 7/5 0.01014/0.00703 -0.31% -30.7% 6e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 11 0.8% 2/9 0.00290/0.01266 +0.98% +77.1% 6e-2 25 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 10 0.7% 10/0 0.01449/0.00000 -1.45% -100.0% 8e-4 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S] N/A 1401 9 0.6% 7/2 0.01014/0.00281 -0.73% -72.3% 1e-1 21 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 9 0.6% 4/5 0.00580/0.00703 +0.12% +17.6% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 9 0.6% 4/5 0.00580/0.00703 +0.12% +17.6% 1e+0 26 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 8 0.6% 5/3 0.00725/0.00422 -0.30% -41.8% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 8 0.6% 5/3 0.00725/0.00422 -0.30% -41.8% 5e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 8 0.6% 3/5 0.00435/0.00703 +0.27% +38.2% 7e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 8 0.6% 4/4 0.00580/0.00563 -0.02% -3.0% 1e+0 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 8 0.6% 1/7 0.00145/0.00985 +0.84% +85.3% 7e-2 14 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 8 0.6% 1/7 0.00145/0.00985 +0.84% +85.3% 7e-2 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 8 0.6% 8/0 0.01159/0.00000 -1.16% -100.0% 3e-3 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 8 0.6% 8/0 0.01159/0.00000 -1.16% -100.0% 3e-3 13 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,G257-,W258-,T259-,G261D,A262-,A263-,A264-,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,S943G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 7 0.5% 4/3 0.00580/0.00422 -0.16% -27.2% 7e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 7 0.5% 6/1 0.00870/0.00141 -0.73% -83.8% 7e-2 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 7 0.5% 4/3 0.00580/0.00422 -0.16% -27.2% 7e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,R346K,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 7 0.5% 1/6 0.00145/0.00844 +0.70% +82.8% 1e-1 25 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 7 0.5% 7/0 0.01014/0.00000 -1.01% -100.0% 7e-3 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,G446S,E484A,F490S,P681H] N/A 1401 6 0.4% 5/1 0.00725/0.00141 -0.58% -80.6% 1e-1 22 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 6 0.4% 2/4 0.00290/0.00563 +0.27% +48.5% 7e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1401 6 0.4% 2/4 0.00290/0.00563 +0.27% +48.5% 7e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 6 0.4% 5/1 0.00725/0.00141 -0.58% -80.6% 1e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,E156D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 6 0.4% 6/0 0.00870/0.00000 -0.87% -100.0% 1e-2 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 6 0.4% 1/5 0.00145/0.00703 +0.56% +79.4% 2e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,R346K,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 6 0.4% 6/0 0.00870/0.00000 -0.87% -100.0% 1e-2 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258-,A264D,I332V,+344S,R346-,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 1401 5 0.4% 3/2 0.00435/0.00281 -0.15% -35.3% 7e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 5 0.4% 2/3 0.00290/0.00422 +0.13% +31.3% 1e+0 81 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 5 0.4% 0/5 0.00000/0.00703 +0.70% +100.0% 6e-2 11 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 5 0.4% 0/5 0.00000/0.00703 +0.70% +100.0% 6e-2 45 +[S31Y,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446T,N450D,L452K,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,V622-,A623-,N641I,V642-,Q644P,+644MAE,Q675K,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F490S,P681H] N/A 1401 5 0.4% 0/5 0.00000/0.00703 +0.70% +100.0% 6e-2 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,M177I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 4 0.3% 3/1 0.00435/0.00141 -0.29% -67.7% 4e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 4 0.3% 1/3 0.00145/0.00422 +0.28% +65.7% 6e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 4 0.3% 3/1 0.00435/0.00141 -0.29% -67.7% 4e-1 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 4 0.3% 3/1 0.00435/0.00141 -0.29% -67.7% 4e-1 23 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,Q613H,P621S,V642G,N679R,P681R,S939F,H1101N,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1401 4 0.3% 4/0 0.00580/0.00000 -0.58% -100.0% 6e-2 19 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K417T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 1401 4 0.3% 4/0 0.00580/0.00000 -0.58% -100.0% 6e-2 19 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 4 0.3% 0/4 0.00000/0.00563 +0.56% +100.0% 1e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 4 0.3% 0/4 0.00000/0.00563 +0.56% +100.0% 1e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,S256L,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 4 0.3% 0/4 0.00000/0.00563 +0.56% +100.0% 1e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K150R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 4 0.3% 4/0 0.00580/0.00000 -0.58% -100.0% 6e-2 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,G446S,E484A,F490S,P681H] N/A 1401 4 0.3% 0/4 0.00000/0.00563 +0.56% +100.0% 1e-1 28 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,I934V,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1401 3 0.2% 2/1 0.00290/0.00141 -0.15% -51.5% 6e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1146G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 3 0.2% 2/1 0.00290/0.00141 -0.15% -51.5% 6e-1 16 +[+16KPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 19 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 3 0.2% 1/2 0.00145/0.00281 +0.14% +48.5% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153K,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 3 0.2% 2/1 0.00290/0.00141 -0.15% -51.5% 6e-1 72 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 3 0.2% 1/2 0.00145/0.00281 +0.14% +48.5% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258-,A264D,I332V,+344S,R346-,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E,E1258D]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,G446D,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,T478K,E484A,F490S,N679K,P681H] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,P793S,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 3 0.2% 2/1 0.00290/0.00141 -0.15% -51.5% 6e-1 27 +[L5F,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 3 0.2% 2/1 0.00290/0.00141 -0.15% -51.5% 6e-1 10 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,G446D,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,T478K,E484A,F490S,N679K,P681H] N/A 1401 3 0.2% 0/3 0.00000/0.00422 +0.42% +100.0% 2e-1 74 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 3 0.2% 2/1 0.00290/0.00141 -0.15% -51.5% 6e-1 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,S98F,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,R346K,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 3 0.2% 0/3 0.00000/0.00422 +0.42% +100.0% 2e-1 2 +[L5F,+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 3 0.2% 1/2 0.00145/0.00281 +0.14% +48.5% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,K1245R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,G446S,E484A,F490S,P681H] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,G446S,E484A,F490S,P681H] N/A 1401 3 0.2% 1/2 0.00145/0.00281 +0.14% +48.5% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,S1170P]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,P1162S,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 3 0.2% 0/3 0.00000/0.00422 +0.42% +100.0% 2e-1 29 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 3 0.2% 1/2 0.00145/0.00281 +0.14% +48.5% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 3 0.2% 2/1 0.00290/0.00141 -0.15% -51.5% 6e-1 21 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,Q675H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 3 0.2% 3/0 0.00435/0.00000 -0.43% -100.0% 1e-1 33 +[R21T,T22N,P26H,S31P,S50L,V127F,M153I,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 28 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 19 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A684T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 8 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 79 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,T124I,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 79 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1084Y,D1184E]-[T19I,L24-,P25-,P26-,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,Y145N,H146-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,R102G,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,I1198V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,T478E,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,I1132V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 29 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 9 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,D1259Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 27 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,T791A,S939F,P1143L,D1260E,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 24 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 26 +[L5F,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 22 +[T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,K776R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 75 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,A123V,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 75 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,T638I,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,S60P,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,K444T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K150N,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A942V,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,T259I,A262V,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 79 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 34 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446T,N450D,L452K,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,V622-,A623-,N641I,V642-,Q644P,+644MAE,Q675K,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 44 +[S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446T,N450D,L452K,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,V622-,A623-,N641I,V642-,Q644P,+644MAE,Q675K,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 28 +[S31P,S50L,H69-,V70-,V127F,N137T,F157S,R158G,L179R,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679T,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,T676N,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 2 0.1% 0/2 0.00000/0.00281 +0.28% +100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 2 0.1% 2/0 0.00290/0.00000 -0.29% -100.0% 2e-1 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 2 0.1% 1/1 0.00145/0.00141 -0.00% -3.0% 1e+0 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,D138H,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 29 +[L5F,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 29 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 24 +[R21T,T22N,S31P,S50L,I68-,H69-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,R214H,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679T,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S929I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,S680F,P681R,S704L,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,G72R,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,L1203F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157L,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E,R1185H]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 11 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,V615F,P621S,P681R,S939F,S943G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143F,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,L54F,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,W152R,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L,D1184Y]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,D936H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 73 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,G639S,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 73 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E,C1250F]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 73 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,V159F,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,W152R,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 74 +[P9L,R21T,P26L,N30S,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,A243-,L244-,P251S,W258C,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L,P1263S,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K150R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 84 +[P9L,L18F,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,E309G,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,V83F,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 83 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,A688D,S704L,K795T,A852K,S939F,N1125D,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V367I,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 30 +[S31P,S50L,H69-,V70-,V127F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,A688V,S939F,P1143L,D1153A]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F486P,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143F,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,W64L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,G1251V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 39 +[S31P,S50L,H69-,V70-,V127F,F157L,R158G,K182R,R190S,+209T,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,Q613H,P621S,V642G,N679R,P681R,A688T,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 23 +[+16MPLF,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 29 +[S31P,S50L,H69-,V70-,E96D,V127F,E156D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 23 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,M153V,E156D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 8 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,Q677R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,K444T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,G75V,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,T323I,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,T1117I,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,T286I,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 16 +[+16MPLF,R21T,S31-,S50L,H69-,V70-,I101T,V127F,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,T376N,R403K,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,S673T,N679R,P681R,S939F,V1104L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T376A,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 85 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,S477D,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,Q675H,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,S477N,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 85 +[+7F,P9-,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1084Y,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,G257V,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,P807S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,W64R,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K417T,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,A688V,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,C1243F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,G219D,H245N,G252-,+253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 26 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,R683Q,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 26 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,R683Q,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 25 +[L5F,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,T259S,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 26 +[L5F,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,S221L,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N657S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,E224Q,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T274I,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,P807S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,Q677L,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T307I,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 26 +[S31P,S50L,H69-,V70-,V127F,M153I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,V1228L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 20 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A1087S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258S,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 82 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 24 +[L5F,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 10 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 21 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,T859I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,A123V,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,Q675H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,I670M,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 9 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 5 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 27 +[S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,Q677R,S939F,V1104L,P1143L,D1153G]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 16 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,G268S,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,I569V,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H,Q954H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R765L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N641S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 28 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,G446N,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,G446S,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 28 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 8 +[R21T,T22N,S50L,F59S,H69-,V70-,I105V,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 85 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,S98F,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,Q173H,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,P1162L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677L,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 76 +[P9L,R21T,P26L,A67V,H69P,V70-,S71-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 77 +[P9L,R21-,+22I,P26L,A67V,H69-,V70-,T95I,I101T,A123V,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 75 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,A522S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 76 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,A123V,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,P793L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 77 +[P9L,R21T,P26L,A67V,H69P,V70-,S71-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,T678S,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 24 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A879S,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 9 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 22 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,Q134H,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 41 +[T19R,E156G,F157-,R158-,A222V,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 31 +[S31P,S50L,H69-,V70-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,E96D,V127F,Q134H,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 32 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,T500A,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 29 +[S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,T761A,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 27 +[+16MPLF,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,A899V,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 32 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,I1115V,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 29 +[S31P,S50L,H69-,V70-,G75V,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 32 +[S31P,S50L,H69-,V70-,V127F,N148Y,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 29 +[S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,E702D,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 28 +[+16MPLF,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,Q954Y,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H,Q954H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,M177T,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,T250P,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,W64L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,S680F,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 21 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,I105V,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,V622I,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,E309Q,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,S71F,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,N603S,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,G268S,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1061I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,Q218R,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,M1237V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,D1146N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,E1017D,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,W258L,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 15 +[N17M,+17P,T19F,T20N,R21L,T22I,Q23I,L24T,P25N,P26Q,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445Q,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,H49Y,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,K1191M]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,G1124D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,G932S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N185S,N211-,L212I,V213G,L216F,H245N,D253G,S256L,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A684T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251L,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,G482D,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,S60P,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S689G,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 11 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 7 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 19 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 21 +[T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,M1050I,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 22 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,T547I,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 21 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251S,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 21 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,D1118E,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 22 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L,S1170F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 80 +[P9L,R21T,P26L,T63I,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1084Y,D1184E]-[T19I,L24-,P25-,P26-,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 80 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1084Y,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 11 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,R190T,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 82 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 25 +[R21T,T22N,S31P,S50L,A67V,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G257S,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,R408S,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,M177I,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 7 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,A123S,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,I934V,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,R683L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,D1084N,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,Q1113K,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 2 +[+16TPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,K1181N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A899S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,D178N,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K150R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A222V,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,D950E,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1079S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,I1115V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 14 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,V289L,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,K462E,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A852V,S939F,S943G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 9 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,L1203F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,M153I,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,P681R,E748Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 22 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,Q613H,P621S,V642G,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q675K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,E1188D]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,Q134K,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 21 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,P1143L,Q1208H]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F135L,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 84 +[P9L,R21T,P26L,A67V,H69-,V70-,R78M,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 82 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S698L,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 28 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251S,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 28 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 24 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,G482S,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 44 +[S31Y,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446T,N450D,L452K,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,V622-,A623-,N641I,V642-,Q644P,+644MAE,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 26 +[S31P,S50L,H69-,V70-,G72R,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 26 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,G75A,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 29 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 36 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,V445L,F486S,E554K,A570V,P621S,P681R,T791A,S939F,K964R,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 31 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 31 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S750G,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,S371F,S375F,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 53 +[S31Y,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446A,T547K,E554K,A570V,N641I,V642-,Q644P,+644MAE,Q675K,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F486P,F490S,Q498R,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 39 +[L5F,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 10 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 27 +[S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,S254F,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 13 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 82 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,E154A,F157S,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S750G,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,R190S,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 28 +[S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 33 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,T678-,+679K,P681R,S939F,I1115V,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,T961M,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A845S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A688S,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,I105V,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,D88E,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483R,E484-,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,M731I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,V622F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,K113R,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,P384S,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,A688S,S939F,P1143L,S1170F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N641K,P681R,S939F,F1103L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N188S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445Q,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,D1139H,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,P1263S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,S60P,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,A243T,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,E654K,I670M,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,I1115V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147T,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,E156D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,T500A,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 22 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 9 +[R21T,T22N,S50L,F59S,H69-,V70-,S112L,V127F,F157S,R158G,K182R,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,Q1201R,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 22 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,I1227V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 8 +[R21T,T22N,S50L,F59S,H69-,V70-,T95I,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 8 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 6 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445Q,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1069S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 85 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,A123V,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,G1099S,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 21 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G257R,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 5 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 21 +[L5F,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 84 +[P9L,R21T,P26L,H49Y,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,N185D,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,G946R,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211T,L212G,V213-,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I326V,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,D111N,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K417T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,K1245R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,K462T,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 21 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 21 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,R273S,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 22 +[R21T,T22N,S31P,S50L,H69-,V70-,G72E,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 21 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 21 +[T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,G482S,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 8 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,L249F,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,T478K,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 19 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G257R,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1228L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,F1103S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16KPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T284I,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,M177I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,K1086E,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642G,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,K187E,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1401 1 0.1% 0/1 0.00000/0.00141 +0.14% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258R,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 30 +[R21T,T22N,P26H,S31P,S50L,H69-,V70-,V127F,M153I,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 31 +[R21T,T22N,S31P,S50L,V127F,M153I,K182R,R190S,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483G,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1401 1 0.1% 1/0 0.00145/0.00000 -0.14% -100.0% 5e-1 32 +[R21T,T22N,P26H,S31P,S50L,V127F,M153I,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H]
last modified: Mon Jan 8 13:32 2024
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Questions or comments? Contact us at seq-info@lanl.gov.
