COVID-19 Viral Genome Analysis Pipeline
Enabled by data from
Frequency Changes in Common Forms
Last update: Sep 9, 2026
Download
SPIKE sequences: Exhaustive list of Last 60 days, Global, Do not break out by lineage
Compute mutations relative to XBB.1.5 baseline sequence
As new lineages emerge, there are often many sequences with many ambiguous base calls. Our pipeline filters out such sequences, and as a consequence we undercount the number of sequences in GISAID that have been specified as members of related Pango lineages. Our strategy, however, enables us to use strictly high quality sequences to identify and track the common forms in emerging lineages.
COMMON FORMS CHANGES FOR SPIKE WITH A GIVEN PANGO LINEAGE DESIGNATION
For each lineage, we show the most common forms of SPIKE, and we show the forms that are most significantly increasing or decreasing. Also shown is the Hamming distance (HD) between each form and the most common form in that lineage. Deletions relative to the baseline reference strain are indicated with a dash (e.g. the two amino acid deletion at positions 156-157 is indicated with 'E156-,F157-'), and insertions are denoted by a plus sign (e.g. an extra T at position 143 is written '+143T'). Abs Differences in later vs early fractions, expressed as percent. Relative Differences range between -100% and +100%, using formula: rel = 100*(later-early)/max(later,early) percent, applied to the early and later fractions. The p-value associated with increase or decrease is computed by Fisher's exact test, and is meant to be used only as a rough guide to the significance of the change. Since the computation is based on assumptions (such as independent and unbiased sampling) that may not hold in practice, the p-value should not be taken too literally. The first line of each lineage section indicates counts for the full lineage relative to all the sequences. 'Lineage Count' in this first line is actually the full sequence count. 'Form Count' in this first line is actually the full lineage count, and 'Form Pct' refers to lineage count relative to full sequence set.
We show all the forms.
[Note: Mutation strings are relative to baseline XBB.1.5].
This output is based on 1920 sequences sampled from 2026-06-27 to 2026-08-26
This total interval is split into two sub-intervals.
Total: 2026-06-27 to 2026-08-26 (1920)
Early: 2026-06-27 to 2026-07-19 (950)
Later: 2026-07-20 to 2026-08-26 (970)
Baseline XBB.1.5: [T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,N501Y,Y505H,D614G,H655Y,N679K,P681H,N764K,D796Y,Q954H,N969K]
Pango Lineage Form Form Counts Fractions Differences Lineage Count Count Pct Early/Later Early/Later Abs Relative pval HD [Form as mutation string] N/A 1920 167 8.7% 88/79 0.09263/0.08144 -1.12% -12.1% 4e-1 0 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 123 6.4% 58/65 0.06105/0.06701 +0.60% +8.9% 6e-1 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 109 5.7% 55/54 0.05789/0.05567 -0.22% -3.8% 8e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 72 3.8% 39/33 0.04105/0.03402 -0.70% -17.1% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 67 3.5% 21/46 0.02211/0.04742 +2.53% +53.4% 3e-3 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 60 3.1% 31/29 0.03263/0.02990 -0.27% -8.4% 8e-1 16 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 45 2.3% 32/13 0.03368/0.01340 -2.03% -60.2% 4e-3 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 30 1.6% 18/12 0.01895/0.01237 -0.66% -34.7% 3e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 29 1.5% 16/13 0.01684/0.01340 -0.34% -20.4% 6e-1 83 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 26 1.4% 9/17 0.00947/0.01753 +0.81% +45.9% 2e-1 27 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 25 1.3% 16/9 0.01684/0.00928 -0.76% -44.9% 2e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 24 1.2% 12/12 0.01263/0.01237 -0.03% -2.1% 1e+0 14 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 23 1.2% 11/12 0.01158/0.01237 +0.08% +6.4% 1e+0 14 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 19 1.0% 9/10 0.00947/0.01031 +0.08% +8.1% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 17 0.9% 7/10 0.00737/0.01031 +0.29% +28.5% 6e-1 7 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 17 0.9% 1/16 0.00105/0.01649 +1.54% +93.6% 3e-4 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 17 0.9% 13/4 0.01368/0.00412 -0.96% -69.9% 3e-2 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 17 0.9% 5/12 0.00526/0.01237 +0.71% +57.5% 1e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445Q,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 16 0.8% 13/3 0.01368/0.00309 -1.06% -77.4% 1e-2 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 1920 16 0.8% 7/9 0.00737/0.00928 +0.19% +20.6% 8e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 13 0.7% 6/7 0.00632/0.00722 +0.09% +12.5% 1e+0 11 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 13 0.7% 8/5 0.00842/0.00515 -0.33% -38.8% 4e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1920 12 0.6% 2/10 0.00211/0.01031 +0.82% +79.6% 4e-2 26 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 11 0.6% 2/9 0.00211/0.00928 +0.72% +77.3% 6e-2 22 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,Q613H,P621S,V642G,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 10 0.5% 6/4 0.00632/0.00412 -0.22% -34.7% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 10 0.5% 6/4 0.00632/0.00412 -0.22% -34.7% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,R346K,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 10 0.5% 5/5 0.00526/0.00515 -0.01% -2.1% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 10 0.5% 3/7 0.00316/0.00722 +0.41% +56.2% 3e-1 74 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 10 0.5% 9/1 0.00947/0.00103 -0.84% -89.1% 1e-2 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 9 0.5% 4/5 0.00421/0.00515 +0.09% +18.3% 1e+0 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 9 0.5% 1/8 0.00105/0.00825 +0.72% +87.2% 4e-2 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 9 0.5% 7/2 0.00737/0.00206 -0.53% -72.0% 1e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258-,A264D,I332V,+344S,R346-,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 1920 9 0.5% 4/5 0.00421/0.00515 +0.09% +18.3% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251S,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 9 0.5% 8/1 0.00842/0.00103 -0.74% -87.8% 2e-2 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 9 0.5% 7/2 0.00737/0.00206 -0.53% -72.0% 1e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,R346K,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 9 0.5% 9/0 0.00947/0.00000 -0.95% -100.0% 2e-3 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 8 0.4% 5/3 0.00526/0.00309 -0.22% -41.2% 5e-1 20 +[T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 8 0.4% 2/6 0.00211/0.00619 +0.41% +66.0% 3e-1 81 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 8 0.4% 3/5 0.00316/0.00515 +0.20% +38.7% 7e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 8 0.4% 4/4 0.00421/0.00412 -0.01% -2.1% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 8 0.4% 5/3 0.00526/0.00309 -0.22% -41.2% 5e-1 25 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 8 0.4% 0/8 0.00000/0.00825 +0.82% +100.0% 8e-3 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,N679K,P681H] N/A 1920 8 0.4% 4/4 0.00421/0.00412 -0.01% -2.1% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P793S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 7 0.4% 2/5 0.00211/0.00515 +0.30% +59.2% 5e-1 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 6 0.3% 5/1 0.00526/0.00103 -0.42% -80.4% 1e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 6 0.3% 4/2 0.00421/0.00206 -0.21% -51.0% 4e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 6 0.3% 1/5 0.00105/0.00515 +0.41% +79.6% 2e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 6 0.3% 3/3 0.00316/0.00309 -0.01% -2.1% 1e+0 39 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,L110S,V127F,F157S,R158G,K182R,R190S,N211I,L212G,V213H,R214N,D215I,L216-,S221W,H245N,A264D,T307P,G311E,I332V,L335F,A344D,+355T,R357N,I358-,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,Q474R,N481K,V483-,E484K,N487D,Q493E,G496E,F497I,P499T,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,A1174V,D1199H]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 6 0.3% 0/6 0.00000/0.00619 +0.62% +100.0% 3e-2 25 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 6 0.3% 3/3 0.00316/0.00309 -0.01% -2.1% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,S256L,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 6 0.3% 6/0 0.00632/0.00000 -0.63% -100.0% 1e-2 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 6 0.3% 5/1 0.00526/0.00103 -0.42% -80.4% 1e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,M177I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 6 0.3% 4/2 0.00421/0.00206 -0.21% -51.0% 4e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 5 0.3% 5/0 0.00526/0.00000 -0.53% -100.0% 3e-2 31 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 5 0.3% 0/5 0.00000/0.00515 +0.52% +100.0% 6e-2 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 5 0.3% 5/0 0.00526/0.00000 -0.53% -100.0% 3e-2 45 +[S31Y,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446T,N450D,L452K,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,V622-,A623-,N641I,V642-,Q644P,+644MAE,Q675K,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F490S,P681H] N/A 1920 5 0.3% 4/1 0.00421/0.00103 -0.32% -75.5% 2e-1 21 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,Q675H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 4 0.2% 1/3 0.00105/0.00309 +0.20% +66.0% 6e-1 4 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 4 0.2% 0/4 0.00000/0.00412 +0.41% +100.0% 1e-1 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 4 0.2% 1/3 0.00105/0.00309 +0.20% +66.0% 6e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,G446S,T478K,E484A,F490S,P681H] N/A 1920 4 0.2% 0/4 0.00000/0.00412 +0.41% +100.0% 1e-1 29 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 4 0.2% 3/1 0.00316/0.00103 -0.21% -67.4% 4e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,I934V,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1920 4 0.2% 2/2 0.00211/0.00206 -0.00% -2.1% 1e+0 17 +[+16KPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 4 0.2% 3/1 0.00316/0.00103 -0.21% -67.4% 4e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 4 0.2% 4/0 0.00421/0.00000 -0.42% -100.0% 6e-2 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 4 0.2% 1/3 0.00105/0.00309 +0.20% +66.0% 6e-1 5 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,P681H] N/A 1920 4 0.2% 2/2 0.00211/0.00206 -0.00% -2.1% 1e+0 75 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,A123V,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 4 0.2% 2/2 0.00211/0.00206 -0.00% -2.1% 1e+0 16 +[+16KPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 4 0.2% 3/1 0.00316/0.00103 -0.21% -67.4% 4e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K150R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 4 0.2% 1/3 0.00105/0.00309 +0.20% +66.0% 6e-1 28 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 4 0.2% 2/2 0.00211/0.00206 -0.00% -2.1% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,E156D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 4 0.2% 4/0 0.00421/0.00000 -0.42% -100.0% 6e-2 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K150N,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 4 0.2% 3/1 0.00316/0.00103 -0.21% -67.4% 4e-1 21 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 4 0.2% 0/4 0.00000/0.00412 +0.41% +100.0% 1e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 1/2 0.00105/0.00206 +0.10% +48.9% 1e+0 22 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 3 0.2% 1/2 0.00105/0.00206 +0.10% +48.9% 1e+0 83 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,S98F,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,Q173H,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N185S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 30 +[S31P,S50L,H69-,V70-,V127F,W152R,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 3 0.2% 1/2 0.00105/0.00206 +0.10% +48.9% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 3 0.2% 1/2 0.00105/0.00206 +0.10% +48.9% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 3 0.2% 1/2 0.00105/0.00206 +0.10% +48.9% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 1/2 0.00105/0.00206 +0.10% +48.9% 1e+0 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 3/0 0.00316/0.00000 -0.32% -100.0% 1e-1 10 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 2/1 0.00211/0.00103 -0.11% -51.0% 6e-1 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,S98F,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,R346K,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 3 0.2% 3/0 0.00316/0.00000 -0.32% -100.0% 1e-1 2 +[L5F,+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 3/0 0.00316/0.00000 -0.32% -100.0% 1e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,S1170P]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 2/1 0.00211/0.00103 -0.11% -51.0% 6e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 2/1 0.00211/0.00103 -0.11% -51.0% 6e-1 29 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 10 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 3/0 0.00316/0.00000 -0.32% -100.0% 1e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 1/2 0.00105/0.00206 +0.10% +48.9% 1e+0 34 +[+16MPLF,R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446T,N450D,L452K,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,V622-,A623-,N641I,V642-,Q644P,+644MAE,Q675K,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F490S,P681H] N/A 1920 3 0.2% 3/0 0.00316/0.00000 -0.32% -100.0% 1e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,G257V,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 3 0.2% 1/2 0.00105/0.00206 +0.10% +48.9% 1e+0 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 2/1 0.00211/0.00103 -0.11% -51.0% 6e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211I,L212R,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 3 0.2% 1/2 0.00105/0.00206 +0.10% +48.9% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,P793S,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 8 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 2/1 0.00211/0.00103 -0.11% -51.0% 6e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 3 0.2% 0/3 0.00000/0.00309 +0.31% +100.0% 2e-1 21 +[L18F,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 9 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,S98F,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I909V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 28 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,P793S,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 23 +[+16MPLF,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 26 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 79 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 13 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,D796H,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H,D796Y] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 38 +[R21T,T22N,S31-,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446T,N450D,L452K,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,V622-,A623-,N641I,V642-,Q644P,+644MAE,Q675K,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,K113R,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 1 +[+16MPLF,R21T,T22N,H49Y,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,K776R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 75 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,T638I,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,S60P,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,S71F,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,A942V,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,T259I,A262V,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 44 +[S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446T,N450D,L452K,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,V622-,A623-,N641I,V642-,Q644P,+644MAE,Q675K,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 28 +[S31P,S50L,H69-,V70-,V127F,N137T,F157S,R158G,L179R,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679T,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,M731I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,P1263S]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,T676N,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 8 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 5 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K417T,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 19 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153K,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T284I,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,T478E,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 22 +[T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 28 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,K444T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 23 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,Q613H,P621S,V642G,N679R,P681R,S939F,H1101N,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,N185D,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 21 +[T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688S,S939F,P1143L,D1153A]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,H1101Q,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 17 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,I1216V,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,S943G,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,A942S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 8 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,I818V,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 2 0.1% 1/1 0.00105/0.00103 -0.00% -2.1% 1e+0 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,T547K,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 22 +[+16MPLF,R21T,T22N,S31P,S50L,F59V,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,Q613H,P621S,V642G,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,D138H,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 2 0.1% 2/0 0.00211/0.00000 -0.21% -100.0% 2e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,G932S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K150N,S151N,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,R346K,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683L,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 4 +[+16MPLF,R21I,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 20 +[L5F,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 2 0.1% 0/2 0.00000/0.00206 +0.21% +100.0% 5e-1 2 +[+16MPLF,R21T,T22N,F32L,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 25 +[R21T,T22N,S31P,S50L,H69-,V70-,S112L,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,D1165N]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 21 +[L5F,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441F,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339L,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,G339H,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,Y145R,H146-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441F,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,+373L,S375A,T376-,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,V772I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,S375F,T376A,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,N556Y,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,Q677H,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,A222S,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529N,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[Q14H,+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,F186L,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 12 +[V3I,R21T,T22N,T33I,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S704L,S939F,S940F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 26 +[P9L,R21T,P26L,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,K444T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 86 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,S98F,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,Q173H,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E,L1234F]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 83 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,G184V,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K150R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 9 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,I235V,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,M1233V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 22 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 5 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 16 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,L176F,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q675R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 28 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,T274N,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 13 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,A942S,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 25 +[S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676P,Q677R,S939F,V1104L,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683Q,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 31 +[S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,S98F,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,Q173H,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,Q677H,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 13 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q675R,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 82 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,S98F,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,Q173H,K187T,N211-,L212I,A243-,L244-,P251S,I326V,G339Y,A348P,A352S,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,D1153H]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q675R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 15 +[S50L,F59S,H69-,V70-,I101M,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 13 +[R21T,P26L,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251S,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,G1124V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 9 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,N280I,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 13 +[S31F,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,R346K,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,N280I,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,G142N,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688S,S939F,P1143L]-[V83A,G142D,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,P174S,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 22 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251S,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,S659L,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251S,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,N334K,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 34 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,Q613H,V615A,P621S,V642G,N679R,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 31 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,T961M,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 30 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,A222S,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258-,A264D,I332V,+344S,R346-,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641K,S680P,P681R,I794T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S704L,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,A475V,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,W64L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,G1251V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,V642G,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,G72W,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,D950N,P1143L,D1146G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,F643-,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 18 +[+16KPLF,R21T,T22N,S31P,S50L,H69-,V70-,S112P,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 85 +[P9L,R21T,P26L,H49Y,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,V705I,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 86 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,K300R,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E,C1247F]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,S477N,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPPF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I844V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,N81D,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,I569V,A570V,P621S,P681R,R683Q,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 27 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,T478I,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,A123V,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 9 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T286I,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R765L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N641S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 28 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,G446N,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,G446S,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 76 +[P9L,R21T,P26L,A67V,H69P,V70-,S71-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 77 +[P9L,R21-,+22I,P26L,A67V,H69-,V70-,T95I,I101T,A123V,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 75 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,A522S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 76 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,A123V,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,P793L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 77 +[P9L,R21T,P26L,A67V,H69P,V70-,S71-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,T678S,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,Y144-,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 9 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 22 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,Q134H,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 41 +[T19R,E156G,F157-,R158-,A222V,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 30 +[S31P,S50L,H69-,V70-,E96D,V127F,Q134H,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 32 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,T500A,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 29 +[S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,T761A,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 32 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,I1115V,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 32 +[S31P,S50L,H69-,V70-,V127F,N148Y,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 29 +[S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,E702D,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 28 +[+16MPLF,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,Q954Y,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H,Q954H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,T250P,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,W64L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,S680F,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 21 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,I105V,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,V622I,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,N603S,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,G268S,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,Q218R,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,M1237V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,D1146N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,E1017D,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,W258L,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[N17M,+17P,T19F,T20N,R21L,T22I,Q23I,L24T,P25N,P26Q,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,K1191M]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,G1124D,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,G932S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,G482D,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 8 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 11 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,R346K,K356T,R403K,A435S,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 7 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,R683L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,D1084N,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 2 +[+16TPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,K1181N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A899S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,D178N,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K150R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A222V,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,D950E,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1079S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,I1115V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 9 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,L1203F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,M153I,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,K1086R,V1104L,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,Q134K,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 21 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,P1143L,Q1208H]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F135L,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 84 +[P9L,R21T,P26L,A67V,H69-,V70-,R78M,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 82 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S698L,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 28 +[S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251S,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 28 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 24 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 26 +[L5F,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,G482S,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 44 +[S31Y,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446T,N450D,L452K,L455S,F456L,N481K,V483-,E484K,Q493E,T547K,E554K,A570V,P621S,V622-,A623-,N641I,V642-,Q644P,+644MAE,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 26 +[S31P,S50L,H69-,V70-,G72R,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 30 +[S31P,S50L,H69-,V70-,G75A,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 36 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,V445L,F486S,E554K,A570V,P621S,P681R,T791A,S939F,K964R,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,N460K,S477N,T478K,E484A,F486P,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 31 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 31 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S750G,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,S371F,S375F,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 53 +[S31Y,S50L,H69-,V70-,V127F,F157S,R158G,R190S,N211G,L212-,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N439K,G446A,T547K,E554K,A570V,N641I,V642-,Q644P,+644MAE,Q675K,P681R,+793P,D839K,S939F,A958S,V1104L,P1143L,D1146G,I1169F,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,G446S,E484A,F486P,F490S,Q498R,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 24 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 39 +[L5F,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,N460K,S477N,T478K,E484A,F486P,F490S,Q498R,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 27 +[S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,S254F,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 13 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 82 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,E154A,F157S,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S750G,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,R190S,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 28 +[S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 33 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,T678-,+679K,P681R,S939F,I1115V,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,D88E,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483R,E484-,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,V622F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,P384S,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680F,P681R,A688S,S939F,P1143L,S1170F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N641K,P681R,S939F,F1103L,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N188S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445Q,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,D1139H,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,E654K,I670M,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,I1115V,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147T,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,E156D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,T500A,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 9 +[R21T,T22N,S50L,F59S,H69-,V70-,S112L,V127F,F157S,R158G,K182R,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,I1227V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 8 +[R21T,T22N,S50L,F59S,H69-,V70-,T95I,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 6 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445Q,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1069S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 85 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,A123V,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,G1099S,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 84 +[P9L,R21T,P26L,H49Y,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,E554K,A570V,T572I,P621S,P681R,S939F,G946R,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,D1146G]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211T,L212G,V213-,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I326V,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,D111N,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,K1245R]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,K462T,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 21 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,R273S,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,F1103S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,D138H,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,M177I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,N440R,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,N440K,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,K1086E,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,V642G,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,K187E,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258R,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,I1198V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,S256L,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,Y145N,H146-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T732I,S939F,P1143L]-[V83A,Y144-,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,K462E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T678I,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,T676N,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,V227I,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679T,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,G72R,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,W258S,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,I670M,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,Q675H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 26 +[S31P,S50L,H69-,V70-,V127F,M153I,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,K444T,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,M177T,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,E309Q,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1061I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 3 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N185S,N211-,L212I,V213G,L216F,H245N,D253G,S256L,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A684T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,P251L,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,S60P,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,Q1113K,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,P681R,E748Q,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 28 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 29 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 27 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 27 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,S680F,P681R,T791A,S939F,P1143L,D1260E,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 27 +[L5F,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 26 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,S60P,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,A243T,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 22 +[R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 21 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G257R,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 21 +[L5F,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 21 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,G257R,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 33 +[R21T,T22N,P26H,S31P,S50L,V127F,M153I,K182R,R190S,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,H1088Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 86 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,M153I,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,K300R,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445S,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E,C1247F]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,E654K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S31F,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 7 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,N280D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,I934V,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,G1267E]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,W152R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,G446I,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,G446S,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 26 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,Q613H,P621S,V642G,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 21 +[T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 25 +[R21T,T22N,S31P,S50L,H69-,V70-,I105V,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,S940C,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T323I,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,A701S,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 6 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,G1219C]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,K147E,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 16 +[S50L,F59S,H69-,V70-,S112L,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 13 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,P1162L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 12 +[S50L,F59S,H69-,V70-,T95I,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,T573I,P621S,P681R,S939F,P1143L,A1174V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 29 +[S31P,S50L,H69-,V70-,E96D,V127F,E156D,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P793S,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 29 +[S31P,T33I,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 32 +[S31P,S50L,H69-,V70-,V127F,H146P,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,Y144-,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,G446S,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 8 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445Q,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 23 +[+16MPLF,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 30 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,T1006S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 10 +[+16MPLF,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 26 +[S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 15 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 11 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 82 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,T547K,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 12 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 11 +[S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445Q,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,G1099S,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S704L,S939F,P1143L,H1159N]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 7 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211I,L212R,V213-,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E516Q,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N641T,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,M153K,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,L441F,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,V1060I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69P,V70-,S71-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,V1104L,P1143L,D1146G,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,T333K,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 24 +[+16MPLF,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,P793S,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 27 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,P793S,S939F,V1104L,P1143L,V1264L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,N641K,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 12 +[N17M,+17P,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T299I,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,T478I,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,L938V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147Q,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,Q1071R,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 23 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,G72E,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532S,E554K,A570V,T572I,Q613H,P621S,V642G,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,T259I,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441R,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,A713S,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,H1101Q,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 21 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446D,N450D,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 5 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S659T,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,V772I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N658K,P681R,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 20 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,S71F,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,I235T,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 26 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 26 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L,V1264L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 28 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,A688V,S939F,P1143L,V1264L]-[L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,F486S,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F486P,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 20 +[+16MPLF,R21T,T22N,S31P,S50L,W64L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264Y,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,G1251V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[+16KPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,A352S,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1228A]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q675H,P681R,S939F,H1083Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,L1224F]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 84 +[F2L,P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 22 +[L5F,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157L,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 24 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 24 +[R21T,T22N,A27-,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[P25-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 85 +[P9L,R21T,P26L,H49Y,A67V,H69-,V70-,P85L,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,Q218H,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,A688V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,V1104I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,S255F,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,V534I,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 85 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,Q677H,N679R,A688D,S704L,K795T,A852K,S939F,G946R,D1184E]-[T19I,L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59-,+60F,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,P681R,A688V,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 82 +[P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,R403K,A435S,N440R,V445A,G446D,L452W,T478N,E484K,G496S,K529N,E554D,A575S,E583D,H625R,N641K,V642G,E654K,N679R,A688D,S704L,K795T,A852K,S939F,D1184E]-[L24-,P25-,P26-,A27S,V83A,G142D,H146Q,Q183E,V213E,G252V,G339H,R346T,L368I,T376A,N440K,V445P,G446S,T478K,E484A,F486P,F490S,Y505H,N679K] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,T259I,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 18 +[+16KPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,S71F,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S704L,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,T1117I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A222S,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445Q,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L,Q1208E]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,L1234I]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683W,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S746T,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,T250I,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 22 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 21 +[R21T,T22N,S31P,S50L,F59S,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 22 +[+16MPLF,R21T,T22N,S31P,S50L,S60P,H69-,V70-,V127F,K147E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,T618I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S689G,S939F,P1143L,A1174V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 10 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,R237K,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,D936N,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 22 +[+16MPLF,R21T,T22N,S31P,S50L,V62A,H69-,V70-,V127F,L141F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,E471Q,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,T678I,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A260V,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,G446D,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 5 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,G446S,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A222S,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,I1216V]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 19 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,V622D,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,T19V,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,P681R,A688V,T791A,S939F,P1143L,V1264L]-[T19I,V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 26 +[S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,S680Y,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,A27S,V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K150E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,N532D,E554K,A570V,T572I,P621S,S680F,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441F,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 10 +[R21T,T22N,S50L,F59S,H69-,V70-,V127F,W152L,+152R,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,T299A,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,T791I,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,V327L,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,N148Y,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 15 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679T,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 16 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,L176F,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A263V,A264D,I332V,K356T,R403K,A435S,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,N487D,Q493E,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,I1221V]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 4 +[+16MPLF,R21T,T22N,H49Y,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 17 +[Q14R,+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,V1133I,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 1/0 0.00105/0.00000 -0.11% -100.0% 5e-1 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L,A1174V,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 21 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,K147E,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,L441I,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,N532K,E554K,A570V,T572I,P621S,S680P,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,G446S,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,A123V,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,D936H,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A222V,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,T95I,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,S680P,P681R,S939F,Q954Y,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H,Q954H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 5 +[+16MSLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 1 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,I1130M,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 7 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184-,N185-,F186-,K187-,N188-,L189-,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,P812S,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,L249S,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,F168V,K182R,R190S,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,G72R,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,D420N,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 15 +[N17M,+17P,T19F,T20N,R21L,T22I,Q23I,L24T,P25N,P26Q,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,Q677H,P681R,S939F,P1143L]-[T19I,L24-,P25-,P26-,V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 4 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,R683W,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,Q134H,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,V534I,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,P1263L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 23 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,L216F,H245N,A264D,I332V,K356T,R403K,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,K529T,E554K,A570V,T572I,T604I,P621S,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,G252V,L368I,V445P,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 20 +[R21T,T22N,S31P,S50L,H69-,V70-,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441I,K444R,V445R,N450D,L452W,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,Q218E,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445H,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L,C1235F]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 2 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,K356T,R403K,K417T,D420N,A435S,V445Q,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,I850V,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,K417N,V445P,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621F,N679R,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,E96D,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,N450D,L452R,L455S,F456L,N481K,V483-,E484K,N487D,Q493E,E554K,A570V,T572I,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 18 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,V127F,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,A435S,L441R,K444R,G446N,N450D,L452W,L455S,F456L,A475V,N481K,V483-,E484K,E554K,A570V,P621S,N679R,P681R,S939F,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,G446S,T478K,E484A,F490S,N679K,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 6 +[+16MPLF,R21T,T22N,S50L,F59S,H69-,V70-,D88E,V127F,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,I358V,R403K,A435S,N450D,L452W,L455S,F456L,N481K,V483-,E484K,Q493E,E554K,A570V,P621S,P681R,S939F,P1143L]-[V83A,H146Q,Q183E,V213E,G252V,R346T,L368I,T478K,E484A,F490S,P681H] N/A 1920 1 0.1% 0/1 0.00000/0.00103 +0.10% +100.0% 1e+0 17 +[+16MPLF,R21T,T22N,S31P,S50L,H69-,V70-,K77R,V127F,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,K356T,R403K,V445R,N450D,L452W,L455S,F456L,T478E,N481K,V483-,E484K,Q493E,E554K,A570V,T572I,P621S,N679R,P681R,S939F,V1104L,P1143L,V1264L]-[V83A,H146Q,Q183E,V213E,G252V,L368I,V445P,T478K,E484A,F490S,N679K,P681H]
last modified: Mon Jan 8 13:32 2024
GISAID data provided on this website is subject to GISAID's Terms and Conditions
Questions or comments? Contact us at seq-info@lanl.gov.
Questions or comments? Contact us at seq-info@lanl.gov.
