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COVID-19 Viral Genome Analysis Pipeline
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This website provides analyses and tools for exploring accruing mutations in hCoV-19 (SARS-CoV-2) geographically and over time, with an emphasis on the Spike protein, using data from GISAID.

The SARS-CoV-2 sequence data used for these analyses was updated from GISAID on Sep 18, 2020

The analyses provided are based on a trimmed full length SARS-CoV-2 alignment containing 56,104 sequences:
sequence names and ID numbers used for full-length analyses,
or on a Spike alignment containing 82,859 sequences:
sequence names and ID numbers used for spike-only analyses.

The details of the analyses are described in:
Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus.
Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B, Hastie KM, Parker MD, Partridge DG, Evans CM, Freeman TM, de Silva TI*, McDanal C, Perez LG, Tang H, Moon-Walker A, Whelan SP, LaBranche CC, Saphire EO, and Montefiori DC.
*on behalf of the Sheffield COVID-19 Genomics Group
Cell, June 2020
DOI:10.1016/j.cell.2020.06.043

News

Sep 3, 2020
We have released a summary of SARS-CoV-2 variation, with a focus on Spike mutations that might impact antibodies, and considerations for vaccine reagents.

Aug 25, 2020
FAQs and answers regarding the D614G mutation in the Spike protein

See more

 






Acknowledgements

We gratefully acknowledge the authors, originating and submitting laboratories of the sequences from GISAID on which this research is based. The original data are available from https://www.gisaid.org

This COVID-19 response analysis pipeline is supported by: The Laboratory Directed Research and Development program of Los Alamos National Laboratory (20200706ER), and by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Interagency Agreement No. AAI12007-001-00000.


GISAID data provided on this website is subject to GISAID’s Terms and Conditions

Questions or comments? Contact us at seq-info@lanl.gov

 
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