XSpike

eXplore the Spike protein sequence in the SARS CoV-2 virus

Evaluating 879 sequences of length 1888
Sampled from 2026-05-07 to 2026-07-06.
Specified Date Range: ('2026-05-07', '2026-07-06')
Highest entropy sites for: Global
  Site Entropy
   445  1.2942
   478  1.1387
   346  0.7380
    31  0.7046
    16  0.0000
    59  0.6929
   184  0.6927
   182  0.6698
   190  0.6646
   444  0.6379
   679  0.6310
   446  0.6240
   420  0.6180
    26  0.5914
   493  0.5735
   572  0.5715
   487  0.5538
    19  0.5495
   529  0.5386
   435  0.5309
   417  0.5181
   441  0.5044
   253  0.4982
    24  0.4939
    25  0.4895
    22  0.4822
    27  0.4546
   486  0.4401
   264  0.4388
   681  0.4317
   142  0.4211
   641  0.4147
   704  0.4138
   376  0.4133
   158  0.4116
   456  0.4111
   642  0.4104
    50  0.4095
   481  0.4087
   688  0.4078
   127  0.4066
    67  0.4057
   440  0.4046
  1143  0.4045
   455  0.4037
   654  0.4022
   483  0.4013

Most highly correlated site-pairs for: Global
               cramerV  mutInfo
   445    478   0.7510   0.7308
    59    184   0.9954   0.6847
    31    190   0.9927   0.6471
   182    190   0.9879   0.6371
    31    182   0.9877   0.6314
   346     31   0.6965   0.6271
   346    182   0.9851   0.6244
   346    190   0.9851   0.6225
   478    487   0.9937   0.5415
   478    572   0.9662   0.5046
   572    487   0.9630   0.5028
   445    446   0.7990   0.4969
   182    444   0.9134   0.4902
    31    444   0.9155   0.4893
   190    444   0.9084   0.4843

    19     25   1.0000   0.4820
    26     50   1.0000   0.4271
    26    483   1.0000   0.4143
    26     67   1.0000   0.4142
    26    127   1.0000   0.4111
   529     50   1.0000   0.4098
   445    654   1.0000   0.4098
   478    654   1.0000   0.4053
   445     67   1.0000   0.4042
   529    654   1.0000   0.4025
   445    688   1.0000   0.4016
   529     67   1.0000   0.3975
    26     24   1.0000   0.4821
    26     25   1.0000   0.4792
    26    654   1.0000   0.4205

Most common patterns for local area, where Local = Global
                                              1
           111111223344444444444444445566666671
11222223556245889564712344444557888892744578804
69245671097728240346670501456568136739212491843
VTTLPPASSFAVGRKGRDARTKDANLKVGLFTNVFNQKTNVENPASP  Global     UK  Eu-UK  NAmer   Asia Africa  SAmer  Ocean   Local  Exact  Pct [Context]
                                                      0      0     50    251    368     28     13    169     585 <----------- Totals
.IN---S.LS.FDG.S.GD.ATNSK..HSSL.K-P.E.....KR..L       0      0      0      1    127      0      0      0     128     63  49% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,D253G,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417T,D420N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,I1216V] 
.....L....V.-........N.SR..AD..N.....N.KGKRHDL.       0      0      0     18     43      1      0      2      64     40  62% [P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y144-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,S371F,S373P,S375F,R403K,D405N,R408S,K417N,A435S,N440R,V445A,G446D,L452W,N460K,S477N,T478N,E484K,G496S,Q498R,N501Y,K529N,E554D,A575S,E583D,D614G,H625R,N641K,V642G,E654K,H655Y,N679R,P681H,A688D,S704L,N764K,K795T,D796Y,A852K,S939F,Q954H,N969K,D1184E] 
.IN---S.LS.FDG.S..D.ANNSK..PSSL.K-P.E.....KR..L       0      0      0      1     43      0      0      8      52     37  71% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,D420N,A435S,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L] 
.IN---SPL..FDGR.S.DTAN.SKRRPSSL.K-P.......RR..L       0      0      0      9     40      1      0      1      51     37  72% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,L441R,K444R,V445P,G446S,N450D,L452W,L455S,F456L,N460K,A475V,S477N,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L] 
.IN---S.LS.FDG.S..D.AN.SK..PSSL.K-P.E.....KR..L       0      0      0      6      1      0      0     38      45     34  75% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L] 
.IN---SPL..FDGR.S.DTAN..K.RPSSLKK-PDE.I...KR..L       0      0      1     27      0      1      0      3      32      9  28% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,E96D,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445P,G446S,N450D,L452R,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L] 
.IN---S.LS.FDG.S..D.AN.SK..HSSL.K-P.E.....KR..L       0      0      0      5     13      0      0      2      20     10  50% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,G268S,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L] 
.IN---SPL..FDGR.S.DTAN..K.RRNSLKK-PDE.I...KR..L       0      0      2      5      5      3      0      4      19      8  42% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,A1174V] 
.IN---S.LS.FDG.S..D.AN.SK..PSSLIK-P.E.....KR..L       0      0      0     17      0      0      0      2      19      5  26% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,S943G,Q954H,N969K,P1143L] 
.IN---SPL..FDGR.S.DTAN..K.RRSSLKK-PDE.I...KR..L       0      0      0     14      1      0      2      1      18      3  16% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,A1174V] 
.....L....V..........N.SR..AD..N.....N.KGKRHDL.       0      0      1      0      0      0      0      9      10      7  70% [P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,S371F,S373P,S375F,R403K,D405N,R408S,K417N,A435S,N440R,V445A,G446D,L452W,N460K,S477N,T478N,E484K,G496S,Q498R,N501Y,K529N,E554D,A575S,E583D,D614G,H625R,N641K,V642G,E654K,H655Y,N679R,P681H,A688D,S704L,N764K,K795T,D796Y,A852K,S939F,Q954H,N969K,D1184E]