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COVID-19 Viral Genome Analysis Pipeline
Enabled by data from   gisaid-logo


XSpike

eXplore the Spike protein sequence in the SARS CoV-2 virus

Last update: Feb 8, 2024

Dates of current data

Delta and Omicron Variants
Global
Wuhan reference
Early 2021 Variants color key
Delta Variants color key
Delta Omicron Variants color key

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Evaluating 100233 sequences of length 1710
Sampled from 2023-12-10 to 2024-01-31.
Specified Date Range: ['2023-12-10', '2024-02-08']
Highest entropy sites for: Global
  Site Entropy
   451  0.9134
   153  0.8148
   448  0.8119
   480  0.7326
    16  0.0041
   142  0.6715
   677  0.6612
    21  0.6606
   479  0.6585
   441  0.6581
   179  0.6548
    66  0.6430
   208  0.6415
   209  0.6377
   486  0.6356
   207  0.6351
    67  0.6342
   154  0.6334
   399  0.6331
   342  0.6329
   477  0.6263
    47  0.6247
  1139  0.6192
   550  0.6181
   617  0.6175
   935  0.6162
   212  0.6161
    80  0.6155
   124  0.6152
   566  0.6138
   241  0.6130
   260  0.6130
   328  0.6110
   446  0.6103
   352  0.6099
   364  0.6029
   452  0.5932
   248  0.5895
    49  0.5140
   474  0.2610
   700  0.1914
   471  0.1835
   568  0.1316
    23  0.0022
    14  0.1075


Most highly correlated site-pairs for: Global
               cramerV  mutInfo
   153    448   0.6825   0.6997
    66     67   0.5000   0.6321
   208    207   0.7131   0.6251
   480    479   0.4740   0.6244
   480    441   0.3780   0.6041
   480     66   0.4941   0.6040
   441     66   0.4939   0.6034
    66     47   0.9868   0.6016
   441    486   0.5741   0.6007
   448    441   0.5035   0.6003
    21     66   0.4922   0.5993
   153    154   0.7031   0.5993
   480     67   0.4932   0.5988
   480     21   0.4027   0.5988
   441     67   0.4929   0.5978


   566    328   0.9920   0.5884
   480    328   0.9882   0.5845
   328    352   0.9881   0.5776
   617    328   0.9879   0.5796
   241    328   0.9878   0.5702
   212    328   0.9874   0.5790
  1139    328   0.9872   0.5786
   209    212   0.9870   0.5820
   441    328   0.9866   0.5825
   328    364   0.9860   0.5719
   124    328   0.9853   0.5743
    66    328   0.9840   0.5879
   209    328   0.9830   0.5700
   935    328   0.9825   0.5698
    67    328   0.9822   0.5831


Most common patterns for local area, where Local = Global
                                            1
         111112222222333334444444444455566791
112244668245570001446245694445577778856617033
461379670423497892180822491681214790606877059
QVRQSQHVAVQFRENLELXXXITKIRXXXXXVKNVASEATPHSSP  Global     UK  Eu-UK  NAmer   Asia Africa  SAmer  Ocean   Local  Exact  Pct [Context]
                                                    0  10526  26376  45917  12591    189   1626   3008   64084 <----------- Totals
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0   1026   7968  19550   2903     32    302   1166   32947  21073  63% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H.....L......HVA.....PNRLLA.............       0    119    306   4278    114      0     80     81    4978   2509  50% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....H............HVA.....PNLFLA.............       0    106    300   1225   1065      0     39    265    3000   1314  43% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..................HVA.....PNLFL..............       0    164    432   1222     59      0    180     75    2132    785  36% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWLFA.K-KFKV.SR.FL       0    158    679    629    460     10      0    195    2131   1037  48% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKVISR.FL       0     60    373    893     31      0      8     33    1398    725  51% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,T568I,P617S,H677R,S935F,P1139L] 
.....H............HVA.....PNLFLA..........L..       0    114    438    603     69      0     17     26    1267    599  47% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S700L] 
K....H............HVA.....PNLFLA.............       0     34     69    191    453      0      3     34     784    340  43% [Q14K,Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....H............HVA.....PDLFLA..........L..       0      3     16    677     16      0      0      1     713    382  53% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S700L] 
..................HVA.....PNLLLAR............       0     37     62    503      3      0      5      1     611    149  24% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,A697V] 
.....H............HVA.....PNLLLA.............       0     48    106    364     51      0     11     17     597    252  42% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..................HVA.....PNLLFAR............       0     48     81    302     33      1      0      8     473     85  17% [E176V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,P517T] 
..T.L.--VFHSGQ-IGFNGDV.TLKHDWSFA.K-KFKV.SR.FL       0     28    106    247     50      2      3      6     442    209  47% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..................HGA.....PNLLFAT............       0    167      6    186      4      5      0      0     368    168  45% [K74R,N144T,N181I,F182-,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249G,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,+370F,F371S,A372-,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474T,P517S] 
..................HVA.....PNLLLAR....K.......       0     79     47    139     68      1      3     15     352    168  47% [E176V,K178Q,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,E550K,A697V] 
..T.L.--VFHSGH-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0     11     28    292      8      0      0      3     342    255  74% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179H,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ..GFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0    276      4     24      0     32      0     336    210  62% [R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K.EFKV.SR.FL       0      0      0      0    323      0      0      0     323    208  64% [+16MPLF,R21T,+23LPP,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,A480E,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..................HVA.....PNLFLAR............       0     24     24    224     14      0      2      9     297    162  54% [E176V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R] 
..................HVA.....PNLFLA..........L..       0      5     30    141     72      0     35      3     286    124  43% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,T569I,S700L] 
..................HGA.....PNLLFAR............       0     64     92    107     10      4      0      2     279     97  34% [N181D,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249G,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,P517S] 
.....H.....L......HVA.....PNLFLA.............       0     25     24    110     74      0      0     38     271    122  45% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....H.....L......HVA.....PNRLLA..........L..       0      4      2    230      4      0      0      0     240    118  49% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440N,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S700L] 
..T.L.--VFHSGQ-IGFNGDVRTL.HDWSFA.K-KFKV.SR.FL       0      1    107      9     33      4     86      0     240     96  40% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..................HVA.....PNLLLA.K..P....R...       0     14     50    174      0      0      0      0     238    178  74% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,S486P,H677R,A697V] 
.....H....KL......HVA.....PNRLLA.............       0      1     12    170      4      0      2      0     189    118  62% [Q49H,Q142K,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.S-.FL       0      1     42    114     25      0      1      4     187     36  19% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677-,+679W,S935F,P1139L] 
..T...--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0    137     39      6      0      0      0     182    105  57% [+16MPLF,R21T,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWLF..K-KFKV.SR.FL       0     15    118     32     11      0      0      3     179    111  62% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H....K.......HVA.....PNLFLA.............       0      2     22     75     67      0      6      5     177     71  40% [Q49H,Q142K,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....H.....L......HVA.....PNLLLA.............       0      5     15    136      5      0      1      8     170     86  50% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..T.L.--VFH..Q-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0    122      3     40      0      0      0     165     95  57% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..................HVA.....PNLFL.I....K.......       0     92     12     43     12      1      0      1     161     30  18% [F76S,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,K474I,E550K] 
R....H............HVA.....PNLFLA.............       0      6      3     44     75      0      0      8     136     69  50% [Q14R,Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....H............HVA.....PNLFL..............       0      5     41     37     36      0      1     11     131     65  49% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E] 
..T.L.--VFHS.Q-IGFNGDVRTLKHDWSFA.K.KFKV.SR.FL       0      0      0      0    130      0      0      0     130     93  71% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SRLFL       0      1     60     53     13      0      0      0     127     63  49% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S700L,S935F,P1139L] 
.....H............HVA.....PNLFLAR............       0     31     29     46      9      0      0      7     122     48  39% [Q49H,K178Q,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R] 
..-.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      6     25     64     10      1      0     12     118     29  24% [N17M,+17P,+18FNFI,I19T,R21-,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV..R.FL       0      0      3     94      5      0      0      0     102     81  79% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,H677R,S935F,P1139L] 
..................HVA.....PNLLFAR......I.....       0      1      7     71     19      0      0      0      98     37  37% [M149I,F182S,Y196C,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243N,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,T568I] 
........V.HL.Q..G.HGA...L.VNRFLA....F........       0      2     22     55      6      0      2     10      97     42  43% [A80V,+140Y,Q142H,K143E,W148R,F153L,E179Q,N181D,I206V,E209G,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253S,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I364L,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440T,X441V,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,P482S,S486F,L854I] 
..T.L.--VFHS.Q-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0      6      0     90      0      0      0      96     60  62% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
H....H............HVA.....PNLFLA.............       0      0      4     21     66      0      1      2      94     66  70% [Q14H,Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSLA.K-KFKV.SR.FL       0      3     14     53     13      0      1      2      86     49  56% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..................HVA.....PNLFL......K....L..       0      3      4     38      3      0     32      0      80     41  51% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,E550K,S700L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KF.V.SR.FL       0      0     29     10     40      0      0      0      79     55  69% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.S..FL       0      2     19     33     17      0      0      2      73     44  60% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,S935F,P1139L] 
..T.L.--VFHSGQ-IVFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0     67      0      0      0      0      0      67     37  55% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209V,+209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
....L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0     58      8      0      1      0      0      67     26  38% [S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H....HL......HVA.....PNRLLA.............       0      0      0     61      3      0      2      0      66     46  69% [Q49H,Q142H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..................HVA....KPNLLFAR............       0      8      6     43      0      2      0      3      62     14  22% [Q169K,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,L331S,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R] 
.....H.....L......HVA.....PNWLLA.............       0      1      0     61      0      0      0      0      62     40  64% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448W,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR..L       0      0      3     24     33      0      0      0      60     43  71% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,P1139L] 
..................HVA.....PNLFL...........L..       0     10      3     25      1      0     20      1      60     19  31% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,S700L] 
K....H....K.......HVA.....PNLFLA.............       0      0      2      5     52      0      0      0      59     27  45% [Q14K,Q49H,Q142K,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....H....K.......HVA.....PNLFLA..........L..       0      5     16     31      1      0      0      2      55     15  27% [Q49H,Q142K,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S700L] 
..........K.......HVA.....PNLFL..............       0      5     14     28      2      0      2      1      52     17  32% [Q142K,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E] 
..T.L.--VFHSGQ-IGFNGDVRTLKVNLLFA.K-KFKV.SR.FL       0      0      3     29     19      0      0      0      51     25  49% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436N,X437L,X438D,X439S,X440K,X441V,X442G,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456N,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H............HVA.....PNLLLAR............       0      6     11     30      2      0      0      1      50     26  52% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R] 
..................HVA.....PNLLLA.............       0      2      4     29      3      0     11      0      49     14  28% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
........V.HL.Q..G.HGA...L.VNRFLA....F.....L..       0     10     23     11      0      0      0      4      48     34  70% [A80V,+140Y,Q142H,K143E,W148R,F153L,E179Q,N181D,I206V,E209G,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253S,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I364L,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440T,X441V,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,P482S,S486F,S700L,L854I] 
.....H............HVA.....PNLFLAR.........L..       0      1      2     41      2      0      0      0      46     30  65% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,S700L] 
..T.L.--VF-SGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      2     16     24      3      0      1      0      46     15  32% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,+140Y,Q142-,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWLFA.K-KFKVISR.FL       0     10     29      5      2      0      0      0      46     27  58% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,T568I,P617S,H677R,S935F,P1139L] 
..T.L.--V.HSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0      0     29     14      0      2      0      45     24  53% [+16MPLF,R21T,S47L,H66-,V67-,A80V,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H............HVA.....PNQFLA.............       0      1      1      4      7      0      0     28      41     26  63% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448Q,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..T.L.--VF.SGQ-IGFNGDVRTLKHDWSFA.K-KFKVISR.FL       0      0      0     41      0      0      0      0      41     38  92% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,T568I,P617S,H677R,S935F,P1139L] 
.....R............HGA.....PDLLFAR............       0      1      5     23      8      0      0      3      40     17  42% [Q49R,K178N,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249G,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,P517S,V1118A] 
.....H.....L..I...HVA.....PNRLLA.............       0      0      0      8      1      0      0     30      39     21  53% [I19X,Q49H,F153L,N207I,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,T1113I] 
..................HVA....KPNLLFA.............       0      1      9     28      0      0      0      0      38     10  26% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,A340T,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S490P,A697V] 
..T.L.--VFHSGQ-IGFNGAVRTLKHDWSFA.K-KFKV.SR.FL       0      1     11     11     14      0      0      0      37     11  29% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257-,X258A,X259A,X260A,+260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
K....H............HVA.....PNLFLA..........L..       0      6      3     17     10      0      0      0      36     20  55% [Q14K,Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S700L] 
.....H.....L.Q....HVA.....PNRLLA.............       0      0      0     36      0      0      0      0      36     22  61% [Q49H,F153L,E179Q,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..................HVA.....PNLFLA.............       0      1      2     23      3      0      1      6      36      9  25% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,V507I] 
..T.L.--VFHSGQ-IGFNGDVSTLKHDWSFA.K-KFKV.SR.FL       0      0      2     32      1      0      0      0      35     29  82% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342S,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..................HVA.....PNLFLAR.........L..       0      0      0     34      0      0      0      0      34     15  44% [A218S,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,T569I,S700L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K.KFKV.SR.FL       0      0      4      0     30      0      0      0      34     22  64% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H.....S......HVA.....PNLFLA.............       0      0      1      3     29      0      0      0      33     20  60% [Q49H,F153S,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....R............HGA.....PDLLFAR....K.......       0      0      3     10      9     11      0      0      33     19  57% [Q49R,K178N,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249G,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,P517S,E550K,V1118A] 
.....H.....L......HVA.....PNRLLAR............       0      0      0     30      2      0      0      0      32     19  59% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R] 
.....H............HVA.....PNLFLA.K...........       0      4      0      0     27      0      1      0      32     20  62% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,N699S] 
..................HVA..T.KPNLLFA.............       0     18      2     11      0      0      0      0      31     12  38% [N144T,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,K352T,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,P482S,A680T,A697V] 
.....H.....L......HVA.....PNRLLA.........R...       0      0      1     30      0      0      0      0      31     17  54% [Q49H,F153L,T204M,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,H677R] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.F.       0     11      3     10      2      0      4      0      30     17  56% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F] 
..................HVA.....PNLLFA.............       0      0      8     11     11      0      0      0      30      9  30% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....H....K.......HVA.....PNLLLA.............       0      1      6     17      5      0      0      0      29      9  31% [Q49H,Q142K,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..................HGA.....PDLLFAR............       0      7      3     17      1      0      0      1      29      8  27% [K178N,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249G,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,P517S] 
..................HVA.R...PNLFL..............       0      0      0      0      0      0     28      0      28      8  28% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244H,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,T342R,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E] 
..T.L.--VFHSGQ-I.FNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0     18      5      4      0      0      0      27     15  55% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,M149X,F153S,R154G,E179Q,N207-,L208I,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..........K.......HVA.....PNLLLAR............       0      0      0     24      3      0      0      0      27      5  18% [Q142K,E176V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R] 
..T.L.--VFHSGQ-.GFNGDVRTLKHDWSFA.K.EFKV.SR.FL       0      0      0      0     26      0      0      0      26      8  30% [+16MPLF,R21T,+23LPP,S24A,S47L,+64A,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,A480E,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..................HVA.....PNLLFA.......I.....       0      1      4      4     17      0      0      0      26     10  38% [Y196C,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,T568I] 
..T.L.--VFHSGQ-IGFNGDVITLKHDWSFA.K-KFKV.SR.FL       0      0      3     16      4      0      0      3      26     15  57% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342I,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
....L...VFHSGQ-IGFNGDVRTLKVNLLFAT..EFKV.SR.FL       0      0      0     25      0      0      0      0      25      7  28% [I19T,+23LPP,S24A,S47L,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,F367S,P369S,F371S,A372T,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413K,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436N,X437L,X438D,X439S,X440K,X441V,X442G,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456N,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N473S,K474T,A480E,P482F,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SP.FL       0      1      2     14      3      0      1      4      25     18  72% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,S676-,H677P,+679R,S935F,P1139L] 
.....H.....L......HVA.....PDRLLA.............       0      0      0     17      2      0      0      6      25     10  40% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..................HVA.....PNLLFAR....K.......       0      2      8     15      0      0      0      0      25      6  24% [E176V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,E550K] 
.....H.....L......NGD.....PNRLLA.............       0      0      0     25      0      0      0      0      25     15  60% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..T.L.--VFHSGQ..GFNGDVRTL.HDWSFA.K-KFKV.SR.FL       0      0     18      0      0      0      7      0      25     14  56% [R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..........K.......HVA.....PNLLFAR............       0      3      2     15      4      0      0      0      24      4  16% [Q142K,E176V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,K300N,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R] 
..................HVA.....PNLFL......Q.......       0      0      0      4     20      0      0      0      24     20  83% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,E550Q] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FF       0      1     13     10      0      0      0      0      24     17  70% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139F] 
..................HVA.....PNLFL......K.......       0     10      7      3      0      0      4      0      24     11  45% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,E550K] 
.....H.....L......HVA.....PNRLLA.....K.......       0      0      0     23      0      0      0      0      23      7  30% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,E550K] 
........V.H--Q.SV.HGA.S.L.VNRLFA....F........       0      0      0      0     11      0      0     11      22      5  22% [+23LSP,S24A,A80V,Q142H,E152G,F153-,R154-,E179Q,P205L,L208S,E209V,D211H,A218V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239-,X240-,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252L,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,H335G,T342S,I364L,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441V,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456N,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S486F,N699I] 
.....H....-L......HVA.....PNRLLA.............       0      0      1     19      0      1      0      1      22      3  13% [Q49H,V140Q,Y141-,Q142-,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..T.L.--VFHLGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0      4     14      0      0      2      2      22     14  63% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153L,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFH..Q-IGFNGDVRTLKHDWLFA.K-KFKV.SR.FL       0      0     22      0      0      0      0      0      22     11  50% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,A684V,S935F,P1139L] 
.....H............HVA.....PNLFL...........L..       0      0     17      2      1      0      0      1      21     10  47% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,S700L] 
..T.L.--VFHSGQ-IGFNGDVRTLKVDWSFA.K-KFKV.SR.FL       0      0      6     14      1      0      0      0      21     10  47% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441V,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..................HVA.....PNLLLAR...PK.......       0      1      2     16      2      0      0      0      21     11  52% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,S486P,E550K,A697V] 
..................HVA.....PNRLLAR....K.......       0      0      0      0      0      0      0     21      21     16  76% [I19X,I65T,N181I,F182-,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,E550K,A697V,A1016S] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWLVA.K-KFKV.SR.FL       0      2     16      1      2      0      0      0      21      6  28% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452V,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H............HVA.....PNLLLA....P........       0      0      0      5     15      0      0      0      20     13  65% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S486P] 
..T.L.F-VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0     12      6      1      0      1      0      20      9  45% [+16MPLF,R21T,S47L,H66F,V67-,S68-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..................HVA.....PNLFL.R............       0      3      1     14      1      0      1      0      20      4  20% [E176V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,K474R] 
........V.........HVA.....PNLFL..............       0      0      1      3      0      0     16      0      20      7  35% [A80V,P82X,F83X,N84X,D85X,G86X,V87X,Y88X,F89X,A90X,+140Y,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,R494X,P495X,T496X,Y497X,G498X,V499X,G500X,H501Y] 
.....H............HVA.....PNLWLA.............       0      5      7      0      6      0      0      1      19      5  26% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451W,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..................HGA.....PNLLFA.............       0      0      5     11      2      0      1      0      19      6  31% [K178N,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249G,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,P517S] 
..................YVA..T..PNLLFAR....K....L..       0      5      1     11      0      2      0      0      19      3  15% [D211H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241Y,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,K352T,X404N,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,E550K,S700L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-EFKV.SR.FL       0      0     16      0      1      0      0      1      18     13  72% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480E,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
...........L......HVA.....PDLFLA..........L..       0      1      3      7      0      0      4      3      18      6  33% [F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,T569I,S700L] 
..........K.......HVA.....PNLFLA..........L..       0      0      2     10      2      0      4      0      18      7  38% [Q142K,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,T569I,S700L] 
.....H.....L......HVA.....PNRLLA........S....       0      2      0     16      0      0      0      0      18     14  77% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,P617S] 
.....H....-.......HVA.....PNLFLA.............       0      0      2      5      9      0      0      2      18      3  16% [Q49H,V140D,+140Q,Y141-,Q142-,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWLFA.K-KF.V.SR.FL       0      0     12      0      6      0      0      0      18      9  50% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKYDWSFA.K-KFKV.SR.FL       0      0      2      9      1      0      0      6      18     13  72% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441Y,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVKTLKHDWSFA.K-KFKV.SR.FL       0      0      3     12      2      0      0      0      17     14  82% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342K,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.R-KFKV.SR.FL       0      1      3     10      1      0      0      2      17     12  70% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477R,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..........-.......HVA.....PNLFL..............       0      0      8      8      1      0      0      0      17      2  11% [+140Y,Y141P,Q142-,G177R,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466N,X467E,R642H] 
..........K.......HVA.....PNLFLAR............       0      0      0     15      0      0      0      2      17      8  47% [Q142K,E176V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.FR.FL       0      1      4      5      6      0      0      1      17      8  47% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617F,H677R,S935F,P1139L] 
.....H.....L......HVA.....PNRFLA.............       0      0      1     12      4      0      0      0      17      9  52% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..................HVA.....PDLFL...........L..       0      0      0      1      0      0     16      0      17     13  76% [L5F,Y196C,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,S700L] 
.....H...FHSGQ-IGFNGDVRTLKPNLFLA.....KV.SR.FL       0      0     17      0      0      0      0      0      17     17 100% [Q49H,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGAVRTLKHDWLFA.K-KFKV.SR.FL       0      0      0      0     16      0      0      0      16      2  12% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSF..K-KFKV.SR.FL       0      2      4      7      3      0      0      0      16     12  75% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKVIS-.FL       0      0      0     16      0      0      0      0      16      8  50% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,T568I,P617S,H677-,+679Q,S935F,P1139L] 
..T.L.--VFHSGQG--FNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0      2     11      2      0      0      0      15      9  60% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,+205T,N207G,L208-,E209-,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H.....L......HVA.....PNRLLAI............       0      0      1     14      0      0      0      0      15     11  73% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474I] 
..I.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0      5      9      0      0      0      1      15     13  86% [+16MPLF,R21I,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..................HVA.....PNLFL......G.......       0      1      2      1      3      0      0      8      15      8  53% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,E550G] 
..T.L.--VFHS.Q-IGFNGDVRTLKHDWLFA.K-KFKV.SR.FL       0      0      1      0     14      0      0      0      15      8  53% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H............HVA.....PNLFLA.....K.......       0      0     12      0      2      0      0      0      14      5  35% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,E550K] 
H.................HVA.....PNLFL..............       0      2      4      2      5      0      1      0      14     10  71% [Q14H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244H,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWLFA.K-KFKV.S-.FL       0      1      3      7      1      0      0      2      14      2  14% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677-,+679W,S935F,P1139L] 
..................HVA.....PNLLFAR.........L..       0      0      0     14      0      0      0      0      14      7  50% [K143N,E176V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,P517S,S700L] 
.....H....K.......HVA.....PDLFLA..........L..       0      1      0     13      0      0      0      0      14     11  78% [Q49H,Q142K,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S700L] 
.....H.....L......YVA.....PNRLLA.............       0      0      0     14      0      0      0      0      14     11  78% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241Y,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
...........L......HVA.....PNLFL..............       0      3      2      2      1      0      4      2      14      8  57% [F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E] 
..................HVA..T..PNLLFA.......I.....       0      0      7      6      1      0      0      0      14      7  50% [R186S,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,K352T,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,T568I,Q671H,A895S,A1066T] 
........V.H--Q.SV.HGA.R.L.VNMLFA....F........       0      0      0      0      8      0      0      5      13      6  46% [+23LSP,S24A,A80V,Q142H,E152G,F153-,R154-,E179Q,P205L,L208S,E209V,D211H,A218V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239-,X240-,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252L,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,H335G,T342R,I364L,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441V,X442S,X443G,X444N,X445Y,X446N,X447Y,X448M,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456N,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S486F,N699I] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWLFA.K-KFKV.SR...       0      0      0      2     10      0      0      1      13      8  61% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSVA.K-KFKV.SR.FL       0      0      8      5      0      0      0      0      13      6  46% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452V,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGD.RTLKHDWSFA.K-KFKV.SR.FL       0      0     10      0      3      0      0      0      13      4  30% [I19T,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H.....L......HVA.....PNRLLA...........F.       0      0      0     12      0      0      1      0      13      9  69% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S935F] 
..T.L.--VFHSGQ-IGFNGDVR.LKHDWSFA.K-KFKV.SR.FL       0      0      6      5      1      0      1      0      13      2  15% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,R353-,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
H.................HVA.....PNLLLA...K.........       0      0     10      3      0      0      0      0      13      6  46% [Q14H,K178E,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,A480K] 
..................HVA.....PDLFL..............       0      8      1      4      0      0      0      0      13      3  23% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E] 
.....H..T.........HVA.....PNLFLA.............       0      0      0      0      0      0      0     13      13     11  84% [I19X,Q49H,A80T,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..........K.......HGA.....PNLLFAR............       0      3      3      6      1      0      0      0      13      2  15% [+140Y,Q142K,K178N,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249G,X250S,X251S,X252S,X253D,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,P517S] 
.....H............HVA.....PNRLLA.............       0      0      3      9      1      0      0      0      13      5  38% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
K....H...........FHVA.....PNLFLA.....K.......       0      0      5      0      8      0      0      0      13      5  38% [Q14K,Q49H,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,E550K] 
..T.L.--VFHSGQ-IGFNGDVRTL.HDWLFA.K-KFKV.SR.FL       0      1      5      0      5      1      0      0      12      3  25% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H.......G....HVA.....PNLFLA.............       0      0      1      3      4      0      0      4      12     10  83% [Q49H,E179G,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
..................YVA.....PNLFLA..........L..       0      0      0     11      0      0      1      0      12     10  83% [X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241Y,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S700L] 
.....H............HVA.....PNLLFAR............       0      0      1     11      0      0      0      0      12      2  16% [Q49H,E176V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R] 
..T.L.--VFHSGQ-IGFNGAVRTL.HDWSFA.K-KFKV.SR.FL       0      0     12      0      0      0      0      0      12      8  66% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..-.L.--VFHSGH-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0      0     11      0      0      0      0      11      7  63% [N17M,+17P,+18FNFI,I19T,R21-,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179H,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
........V.H--Q.SV.HGA.S.L.ANRLFA....F........       0      0      0      0      0      0      0     11      11      8  72% [+23LSP,S24A,A80V,Q142H,E152G,F153-,R154-,E179Q,P205L,L208S,E209V,D211H,A218V,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239-,X240-,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252L,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,H335G,T342S,I364L,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441A,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456N,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,S486F,N699I] 
..T.L.S.VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0      3      2      6      0      0      0      11      6  54% [+16MPLF,R21T,S47L,H66S,S68-,G69-,A80V,V124F,Q142H,W148R,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
...........L......HVA.....PNRLLA.............       0      0      0     11      0      0      0      0      11      1   9% [V44X,L45X,H46X,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,N401D,X404R,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413K,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,L861X] 
.....H.....L......HVA.....PNRLLA.....V.......       0      0      0     11      0      0      0      0      11      6  54% [Q49H,N144T,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,E550V] 
.....HY...K.......HVA.....PNLFLA.............       0      0      0     11      0      0      0      0      11      8  72% [Q49H,H66Y,Q142K,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,E650V] 
.....H..V..L......HVA.....PNRLLA.............       0      0      1     10      0      0      0      0      11      6  54% [Q49H,A80V,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448R,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....H............YVA.....PNLFLA.............       0      2      1      6      2      0      0      0      11      5  45% [Q49H,R210H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241Y,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....H............HVA.....PNLFLA.......I.....       0      0      1      7      2      0      0      1      11      5  45% [Q49H,T92I,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,T568I] 
R.................HVA.....PNLFLA.............       0      2      2      7      0      0      0      0      11      5  45% [Q14R,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,V507I,V1260L] 
...........L......HVA.....PNLLLAR............       0      0      0     11      0      0      0      0      11      4  36% [F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R,A697V] 
..T.L.--VFHSGQ..GFNGDVRTLKHDWLFA.K-KFKV.SR.FL       0      0      9      1      0      0      1      0      11      5  45% [R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451L,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ..GFNGDVRTLKHDWSFA.K-KFKVISR.FL       0      0     11      0      0      0      0      0      11      7  63% [R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,T568I,P617S,H677R,S935F,P1139L,E1146D] 
.....H............HVA..T..PNLFLA.............       0      0      0      0     11      0      0      0      11      8  72% [Q49H,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,K352T,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N699I] 
...........L.Q....HVA.....PDLFLA..........L..       0      0      0     11      0      0      0      0      11      9  81% [F153L,E179Q,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,T569I,S700L] 
..T.L.--VFHSGQ-IGFNGDVRTLKPDWSFA.K-KFKV.SR.FL       0      0      5      5      0      0      0      0      10      4  40% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VF.SGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0      4      5      0      0      0      1      10     10 100% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDV.TLKHDWSFA.K-KFKVISR.FL       0      0      0      8      2      0      0      0      10      8  80% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,T568I,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFA.K-KFK..SR.FL       0      0      3      5      2      0      0      0      10      8  80% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,P617S,H677R,S935F,P1139L] 
..T.L.--V.HSGQ-IGFNGDVRTL.HDWSFA.K-KFKV.SR.FL       0      0      0      8      2      0      0      0      10      2  20% [+16MPLF,R21T,S47L,H66-,V67-,A80V,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
.....H....KL......HVA.....PNLLLA.............       0      0      0     10      0      0      0      0      10      2  20% [Q49H,L51F,Q142K,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451L,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A] 
.....H.....L......HVA.....PNLFLAR............       0      3      6      0      0      0      1      0      10      7  70% [Q49H,F153L,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241H,X242R,X243S,X244Y,X245L,X246T,X247P,X248V,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260A,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441P,X442S,X443G,X444N,X445Y,X446N,X447Y,X448L,X449Y,X450R,X451F,X452L,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,K474R] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDWSFAT..EFKV.SR.FL       0      0      0     10      0      0      0      0      10      4  40% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N473S,K474T,A480E,P482F,S486F,R494Q,Y497N,H501Y,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T.L.--VFHSGQ-IGFNGDVRTLKHDLSFA.K-KFKV.SR.FL       0      0      5      4      1      0      0      0      10      5  50% [+16MPLF,R21T,S47L,H66-,V67-,A80V,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448L,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 
..T......FHSGQ-IGFNGDVRTLKHDWSFA.K-KFKV.SR.FL       0      0      8      2      0      0      0      0      10      4  40% [+16MPLF,R21T,V124F,Q142H,F153S,R154G,E179Q,N207-,L208I,E209G,L212F,X225L,X226P,X227I,X228G,X229I,X230N,X231I,X232T,X233R,X234F,X235Q,X236T,X237L,X238L,X239A,X240L,X241N,X242R,X243S,X244Y,X245L,X246T,X247P,X248G,X249D,X250S,X251S,X252S,X253G,X254W,X255T,X256A,X257G,X258A,X259A,X260D,X261Y,X262Y,X263V,X264G,X265Y,X266L,X267Q,X268P,X269R,X270T,X271F,X272L,X273L,X274K,X275Y,X276N,X277E,X278N,X279G,X280T,X281I,X282T,X283D,X284A,X285V,I328V,T342R,K352T,I364L,R399K,X404S,X405Q,X406I,X407A,X408P,X409G,X410Q,X411T,X412G,X413N,X414I,X415A,X416D,X417Y,X418N,X419Y,X420K,X421L,X422P,X423D,X424D,X425F,X426T,X427G,X428C,X429V,X430I,X431A,X432W,X433N,X434S,X435N,X436K,X437L,X438D,X439S,X440K,X441H,X442S,X443G,X444N,X445Y,X446D,X447Y,X448W,X449Y,X450R,X451S,X452F,X453R,X454K,X455S,X456K,X457L,X458K,X459P,X460F,X461E,X462R,X463D,X464I,X465S,X466T,X467E,V471A,N477K,V479-,A480K,S486F,E550K,A566V,P617S,H677R,S935F,P1139L] 

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