COVID-19 Viral Genome Analysis Pipeline
Enabled by data from
XSpike
eXplore the Spike protein sequence in the SARS CoV-2 virus
Last update: Mar 12, 2026
Delta and Omicron Variants
Global
Wuhan reference
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Evaluating 12260 sequences of length 1884
Sampled from 2025-12-30 to 2026-02-28.
Specified Date Range: ('2025-12-30', '2026-02-28')
Highest entropy sites for: Global
Site Entropy
445 1.1246
478 1.0375
31 0.7054
16 0.0009
487 0.6608
444 0.6450
346 0.6423
572 0.6322
182 0.6224
435 0.6192
190 0.6073
680 0.5610
59 0.5495
184 0.5463
679 0.4771
529 0.4612
452 0.3616
26 0.3522
96 0.3507
1264 0.3440
22 0.3220
19 0.3166
681 0.3116
486 0.3106
376 0.3069
688 0.3054
24 0.2959
25 0.2918
446 0.2893
27 0.2682
493 0.2614
604 0.2443
212 0.2394
101 0.2382
211 0.2373
127 0.2368
440 0.2341
158 0.2257
481 0.2225
483 0.2223
441 0.2206
67 0.2202
641 0.2197
326 0.2196
243 0.2190
704 0.2186
1143 0.2177
Most highly correlated site-pairs for: Global
cramerV mutInfo
445 478 0.6684 0.6141
182 190 0.9890 0.5809
31 182 0.4897 0.5726
31 190 0.9742 0.5617
487 444 0.6700 0.5403
478 487 0.6676 0.5398
346 190 0.9677 0.5392
346 182 0.4814 0.5344
487 572 0.9423 0.5338
59 184 0.9932 0.5299
31 346 0.4777 0.5288
478 31 0.4726 0.5129
478 444 0.9221 0.4955
478 435 0.9284 0.4908
31 435 0.9316 0.4896
24 25 0.9996 0.2873
529 604 0.9742 0.2306
376 101 0.9671 0.2206
24 27 0.9587 0.2455
212 211 0.9479 0.2285
478 59 0.9430 0.4726
22 24 0.9388 0.2205
688 704 0.9360 0.1780
478 704 0.9313 0.1770
445 704 0.9307 0.1758
529 704 0.9297 0.1749
481 243 0.9275 0.1678
26 704 0.9258 0.1793
446 704 0.9235 0.1711
26 158 0.9230 0.1822
Most common patterns for local area, where Local = Global
11
111111222333444444444444455666666712
11222223569025889114247344444578888927047888046
69245671976178240123666501456281367392419018434
VTTLPPASFAEIVRKGRNLAIRTANLKVGLTNVFNQKTTNNSPASPV Global UK Eu-UK NAmer Asia Africa SAmer Ocean Local Exact Pct [Context]
0 453 1695 8523 304 95 437 753 7330 <----------- Totals
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDE.I..K.R..L. 0 10 133 1133 14 0 12 9 1311 503 38% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HSW.K-P.E....K.R..L. 0 6 83 476 44 0 0 25 634 344 54% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP..D.FGR.S-I..TA.K.RPSRKK-PDE.I..K.R..L. 0 3 24 450 1 0 0 3 481 296 61% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,E96D,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445P,G446S,N450D,L452R,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDE.I..KPR..L. 0 6 37 338 6 1 30 7 425 153 36% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDETII.K.R..LL 0 1 9 331 3 0 0 2 346 194 56% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,K529T,E554K,A570V,T572I,T604I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.....L...V.T.....-I-V..SR..ADWN.....N..KR.HDL.. 0 76 164 33 5 0 0 41 319 163 51% [P9L,R21T,P26L,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y144-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,S371F,S373P,S375F,R403K,D405N,R408S,K417N,A435S,N440R,V445A,G446D,L452W,N460K,S477N,T478N,E484K,G496S,Q498R,N501Y,K529N,E554D,A575S,E583D,D614G,H625R,N641K,V642G,E654K,H655Y,N679R,P681H,A688D,S704L,N764K,K795T,D796Y,A852K,S939F,Q954H,N969K,D1184E]
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDE.I..R.R..L. 0 3 53 189 15 0 2 20 282 100 35% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219S,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..PSWIK-P.E....K.R..L. 0 0 42 160 38 0 0 17 257 80 31% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HSWIK-P.E....K.R..L. 0 1 37 190 9 0 0 14 251 124 49% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDE.I..KFR..L. 0 0 7 157 1 0 2 15 182 103 56% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.KIRRSWKK-PDE.I..K.R..L. 0 13 21 144 0 0 0 1 179 100 55% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,L441I,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K..RSWEK-P.E....R.R..LL 0 0 14 126 0 0 0 0 140 52 37% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478E,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L,V1264L]
.IN---SP..D.FGR.S-I..TA.K.RPSRKK-PDE.I..K.RV.L. 0 0 1 118 0 0 0 0 119 91 76% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,E96D,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445P,G446S,N450D,L452R,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,A688V,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.I.---S-...TFG...-I...N.K..PSWKK-P.E....R.R..L. 0 0 0 4 0 0 0 92 96 22 22% [+16MPLF,T19I,R21X,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,I101T,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376N,R403K,D405N,R408S,K417N,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,S673T,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.IN---SP..D.FGR.S....TA.K.RPSRKK-PDE.I..K.R..L. 0 0 0 96 0 0 0 0 96 48 50% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,E96D,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445P,G446S,N450D,L452R,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S....TA.K.RRSWKK-PDE.I..K.R..L. 0 0 1 91 0 0 3 0 95 15 15% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I..TASK..HSW.K-P.E....K.R..L. 0 0 2 72 1 0 0 1 76 25 32% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HSW.K-P.E....K.R..LL 0 1 6 41 20 0 0 1 69 24 34% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.IN---S.S...FG.S.-I...ASK..PSW.K-P.E....K.R..L. 0 2 12 9 17 0 0 22 62 15 24% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,D420N,A435S,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K.RPSW.K-P......K.R..L. 0 0 9 12 0 38 0 0 59 17 28% [+16IPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S....TA.K.RRSWKK-PDE.I..KPR..L. 0 0 3 33 0 0 14 0 50 14 28% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HSW.K-P.E.I..K.R..L. 0 0 16 26 1 0 0 1 44 24 54% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.......P....FGR.S-I..TA.K.RRSWKK-PDE.I..K.R..L. 0 0 24 15 0 0 4 0 43 12 27% [S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S....TA.K.RRSWKK-PDETII.K.R..LL 0 0 0 41 0 0 1 0 42 24 57% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,K529T,E554K,A570V,T572I,T604I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.IN---S.S...FG.S.-I...ASK..PSWIK-P.E....KYR..L. 0 0 2 36 1 0 0 0 39 31 79% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680Y,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HSWIK-P.E....R.R..L. 0 0 4 31 2 0 0 1 38 18 47% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I.VTA.K.RRSWKK-PDE.I..KPR..L. 0 0 0 34 0 0 4 0 38 33 86% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I326V,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K.RRNWKK-PDE.I..K.R..L. 0 0 4 28 0 0 0 2 34 16 47% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335F,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,A1174V]
.IN---SP....FGR.S-I..TASKRRPSW.K-P......R.R..L. 0 0 1 0 32 0 0 0 33 23 69% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,M153I,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,L441R,K444R,V445P,G446S,N450D,L452W,L455S,F456L,N460K,A475V,S477N,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HSWIK-P.E.I..K.R..L. 0 0 3 28 0 0 0 0 31 16 51% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,R683Q,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HSW.K-P.E....KFR..L. 0 0 3 20 4 0 0 0 27 12 44% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S....TA.K..RSWEK-P.E....R.R..LL 0 0 0 26 0 0 0 0 26 11 42% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478E,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L,V1264L]
.IN---SP....FGR.S-I..TASK.RPSWKK-PDE.I..K.R..L. 0 0 0 25 0 0 0 0 25 15 60% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,K444R,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,G932S,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TASK.RRSWKK-PDE.I..K.R..L. 0 0 5 17 0 0 0 2 24 10 41% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDE.I..K.R..LL 0 0 4 16 0 2 0 2 24 7 29% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.IN---SP....FGR.S-I..TASKRRPSWKK-P......R.R..L. 0 0 0 23 0 0 0 0 23 18 78% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,L441R,K444R,V445P,G446S,N450D,L452W,L455S,F456L,N460K,A475V,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-IS..ASK..HSW.K-P.E....K.R..L. 0 0 0 23 0 0 0 0 23 20 86% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,A243S,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K..RSW.K-P.E....R.R..L. 0 0 0 22 0 0 0 0 22 17 77% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDE.I.KKPR..L. 0 0 3 12 0 0 6 0 21 13 61% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,N641K,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TS.K.RRSWKK-PDE.I..K.R..L. 0 1 0 20 0 0 0 0 21 12 57% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,S71F,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,L335S,G339H,R346T,K356T,S371F,S373P,S375F,T376S,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HSW.K-P.E....R.R..L. 0 0 0 3 0 0 0 17 20 6 30% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,G1099S,P1143L]
.IN---SP....FGR.S....TA.K.RRSWKK-PDE.I..KFR..L. 0 0 1 15 0 0 4 0 20 9 45% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.KIRRSWKK-PDE.I..KYR..L. 0 0 0 19 0 0 0 0 19 14 73% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,L441I,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680Y,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HSWIK-P.E.I....R..L. 0 0 5 13 0 0 0 0 18 7 38% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,S256L,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HSW.K-P.E....KPR..L. 0 4 3 0 8 0 0 3 18 4 22% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954Y,N969K,P1143L,Q1201H]
.......P....FGR.S-I..TA.K.RRSWKK-PDETII.K.R..LL 0 0 0 18 0 0 0 0 18 12 66% [S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,K529T,E554K,A570V,T572I,T604I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.IN---S.S...FG.S......ASK..HSW.K-P.E....K.R..L. 0 0 1 16 0 0 0 0 17 9 52% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP..D.FGR.S....TA.K.RPSRKK-PDE.I..K.RV.L. 0 0 0 17 0 0 0 0 17 13 76% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,E96D,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445P,G446S,N450D,L452R,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,A688V,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDETI..K.R..LL 0 0 2 4 0 10 0 0 16 4 25% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,F220V,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,K529T,E554K,A570V,T572I,D614G,P621S,V642G,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,N1187X,V1264L]
.IN---SP....FGR.S-I..TA.KIRRSWKK-PDE.I..KPR..L. 0 0 0 13 3 0 0 0 16 12 75% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,L441I,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TASK..HSW.K-P.E....K.H..L. 0 0 0 1 14 0 0 1 16 6 37% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,K150N,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,T676P,Q677R,N679K,P681H,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.IN---SP....FGR.S....TA.K.RRSWKK-PDE.I..R.R..L. 0 0 0 16 0 0 0 0 16 8 50% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,G219S,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.......P....FGR.S-I..TA.K.RRSWKK-PDE.I..KPR..L. 0 0 3 4 0 0 9 0 16 14 87% [S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDE.I.KK.R..L. 0 6 1 9 0 0 0 0 16 6 37% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,N641K,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..HTWIK-P.E....K.R..L. 0 0 1 13 1 0 0 0 15 12 80% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,G257V,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446T,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDE.I..KYR..L. 0 0 2 12 0 0 1 0 15 13 86% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680Y,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.......P....FGR.S-I..TA.K.RRSWKK-PDE.I..KFR..L. 0 0 11 0 0 0 3 0 14 8 57% [S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,V642G,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP..Y.FGR.S-I..TA.K.RPSRKK-PDE.I..K.R..L. 0 0 0 14 0 0 0 0 14 8 57% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,E96Y,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445P,G446S,N450D,L452R,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S....TA.KIRRSWKK-PDE.I..K.R..L. 0 0 1 13 0 0 0 0 14 7 50% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,L441I,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S....TA.K.RRNWKK-PDE.I..K.R..L. 0 0 1 13 0 0 0 0 14 9 64% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,L335F,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446N,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,A1174V]
......SP....FGR.S-I..TA.K.RRSWKK-PDE.I..K.R..L. 0 0 3 10 0 0 1 0 14 4 28% [A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP.V..FGR.S-I..TA.K.RRSWKK-PDE.I..K.R..L. 0 0 0 13 0 0 0 0 13 7 53% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,A67V,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
......SP....FGR.S-I..TA.K.RRSWKK-PDE.I..KPR..L. 0 0 1 5 0 0 7 0 13 8 61% [A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP.....GR.S-I..TA.K.RRSWKK-PDE.I..KPR..L. 0 0 0 0 0 0 13 0 13 10 76% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
......SP....FGR.S-I..TA.K.RRSWKK-PDETII.K.R..LL 0 0 0 13 0 0 0 0 13 10 76% [A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,K529T,E554K,A570V,T572I,T604I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.....F...V.T.....-I-V..SR..ADWN.....N..KR.HDL.. 0 0 9 0 0 0 0 3 12 8 66% [P9L,R21T,P26F,A67V,H69-,V70-,T95I,I101T,C136-,D138-,P139-,F140-,L141-,G142-,V143-,Y144-,Y145-,H146-,K147-,N149-,F157S,N164K,S172F,K187T,N211-,L212I,+214AS,+215TD,A243-,L244-,P251S,I326V,G339Y,A348P,K356T,S371F,S373P,S375F,R403K,D405N,R408S,K417N,A435S,N440R,V445A,G446D,L452W,N460K,S477N,T478N,E484K,G496S,Q498R,N501Y,K529N,E554D,A575S,E583D,D614G,H625R,N641K,V642G,E654K,H655Y,N679R,P681H,A688D,S704L,N764K,K795T,D796Y,A852K,S939F,Q954H,N969K,D1184E]
.IN---SP.....GR.S....TA.K.RRSWKK-PDE.I..KPR..L. 0 0 0 0 0 0 12 0 12 9 75% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TA.K.RRSWKK-PDE.I..KPR.LL. 0 0 1 10 0 0 0 0 11 5 45% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,S704L,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..TASKIRRSWKK-PDE.I..K.R..L. 0 0 1 10 0 0 0 0 11 4 36% [+16KPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,L441I,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---S.S...FG.S.-I...ASK..PSWIK-P.E....KFR..L. 0 0 0 10 1 0 0 0 11 7 63% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IN---SP....FGR.S-I..IA.K.RRSWKK-PDETII.K.R..LL 0 0 0 10 0 0 0 0 10 9 90% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346I,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,K529T,E554K,A570V,T572I,T604I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
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