COVID-19 Viral Genome Analysis Pipeline
Enabled by data from
XSpike
eXplore the Spike protein sequence in the SARS CoV-2 virus
Last update: Oct 2, 2025
Delta and Omicron Variants
Global
Wuhan reference
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Evaluating 21618 sequences of length 1879
Sampled from 2025-07-28 to 2025-09-26.
Specified Date Range: ('2025-07-28', '2025-09-26')
Highest entropy sites for: Global
Site Entropy
31 0.7921
478 0.7496
445 0.7461
487 0.6626
444 0.6410
572 0.6344
182 0.6326
16 0.0048
346 0.5925
190 0.5677
435 0.5573
59 0.5457
184 0.5407
680 0.3472
679 0.3249
1104 0.3090
22 0.2549
1086 0.2307
186 0.2182
441 0.1913
376 0.1703
1084 0.1473
493 0.1213
212 0.1171
475 0.1073
1264 0.1057
681 0.1019
21 0.0959
101 0.0953
529 0.0925
211 0.0869
1174 0.0798
19 0.0793
26 0.0774
24 0.0758
673 0.0755
484 0.0718
27 0.0671
403 0.0658
958 0.0657
486 0.0649
25 0.0642
677 0.0616
157 0.0544
604 0.0534
417 0.0530
946 0.0523
Most highly correlated site-pairs for: Global
cramerV mutInfo
31 182 0.4955 0.5889
444 182 0.6669 0.5256
31 59 0.5696 0.5178
346 190 0.6892 0.5170
444 572 0.9376 0.5127
31 444 0.6621 0.5114
59 184 0.5674 0.5060
31 190 0.6722 0.5029
445 190 0.6735 0.5016
487 444 0.6557 0.4991
487 572 0.9255 0.4990
31 184 0.5626 0.4950
478 184 0.5561 0.4948
445 435 0.9563 0.4940
31 445 0.4889 0.4931
376 101 0.9975 0.0965
24 25 0.9893 0.0534
435 184 0.9613 0.4848
212 211 0.9601 0.0832
435 59 0.9543 0.4743
31 435 0.9471 0.4634
478 435 0.9393 0.4611
190 435 0.9110 0.4251
1086 186 0.9104 0.1753
346 435 0.9054 0.4159
572 182 0.8955 0.4491
31 572 0.8886 0.4392
376 673 0.8756 0.0661
101 673 0.8671 0.0650
22 21 0.8549 0.0404
Most common patterns for local area, where Local = Global
11111
1111112233444444444444556666669900112
11222222350588891147013444778889270777884588076
69124567191724601266375145584673924379016846444
VTRTLPPASFIFKGFRNLRTRKALKVATEFNQKTTSQNSPGADKVAV Global UK Eu-UK NAmer Asia Africa SAmer Ocean Local Exact Pct [Context]
0 2532 6282 8195 2078 69 772 1690 11700 <----------- Totals
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...K.R....... 0 144 1747 2542 158 13 141 75 4820 2525 52% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.S.S..-I.AKNS..H.IKP.E.....K.R....... 0 35 252 411 986 1 1 324 2010 1078 53% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...KPR....... 0 18 131 193 61 0 167 4 574 332 57% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.S.S..-I.AKNS..H..KP.E.....K.R....... 0 16 65 94 297 0 1 71 544 257 47% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...K.R..G.... 0 13 138 72 30 1 7 6 267 123 46% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,D1084G,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...KFR....... 0 2 42 92 3 0 75 7 221 148 66% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN.IRR.KKPDE.I...K.R....... 0 15 86 83 8 0 0 4 196 100 51% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,L441I,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT.---S-.TS....-I.NKN...P.KKP.E...T.R.R....L.. 0 0 1 1 0 0 0 174 176 113 64% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,I101T,V127F,G142D,Y144-,F157S,R158G,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376N,R403K,D405N,R408S,K417N,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,S673T,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.IT.---S-..S..LS-ITAKN...R.KKP.E.....R.R...RL.. 0 8 42 113 3 1 5 2 174 57 32% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...K.R.S..... 0 7 72 21 0 2 1 2 105 45 42% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,A958S,N969K,P1143L]
.ITN---SP..SR..S..TAKN..RR.KKPDE.I...K.R....... 0 0 78 2 0 0 25 0 105 58 55% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...R.R....... 0 5 44 39 3 0 1 3 95 35 36% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S-..S..LS-ITAKN...R.KKPDE.....K.R...RLV. 0 2 8 60 5 0 2 15 92 40 43% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L,A1174V]
.ITN---SP..SR..S-ITAKN..RR.KKPDETII..K.R......L 0 1 15 71 2 0 0 0 89 47 52% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,K529T,E554K,A570V,T572I,T604I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.ITN---SP..SR..S-ITAKNSRRPVKKP.......R.R....... 0 0 12 61 2 0 2 3 80 64 80% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,L441R,K444R,V445P,G446S,N450D,L452W,L455S,F456L,N460K,A475V,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...K.RR...... 0 3 55 10 0 0 0 2 70 49 70% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,G946R,Q954H,N969K,P1143L]
.IT.---S-..S..LS-ITAKN...R..KP.E.....R.R...RL.. 0 2 6 50 2 0 0 0 60 25 41% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...KPR..G.... 0 0 0 58 0 0 0 0 58 44 75% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,D1084G,P1143L]
.ITN---S-..S..LS-ITAKN...R.KKP.E.....K.R...RL.. 0 6 29 15 0 0 1 0 51 15 29% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.ITN---SP..SR..S-ITAKN..RP.KKPDE.I...K.R....... 0 2 21 23 0 0 0 1 47 11 23% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,E96D,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445P,G446S,N450D,L452R,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKT..RR.KKPDE.I...K.R....... 0 0 0 42 0 0 0 0 42 32 76% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417T,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN...R.KKP.E.....R.R...RL.. 0 1 21 18 0 0 1 1 42 19 45% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDETI...K.R......L 0 1 12 26 1 0 1 0 41 19 46% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,K529T,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.ITN---SP..SR..S-ITSKN..RR.KKPDE.I...K.R....... 0 19 11 8 1 0 0 0 39 17 43% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376S,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S-..S..LS-ITAKN...R.KKP.E.....R.R...RL.. 0 9 5 24 0 0 0 0 38 25 65% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.ITN---SP..SR..S-ITAKN.R.PVKKP.......K.R....... 0 4 21 12 1 0 0 0 38 20 52% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,L441R,V445P,G446S,N450D,L452W,L455S,F456L,N460K,A475V,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,T791A,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I..HK.R....... 0 1 7 23 0 0 0 4 35 19 54% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,Q677H,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.S.S..-I.AKNS..H.IKP.E....HK.R....... 0 0 6 5 19 1 0 3 34 23 67% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,Q677H,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.S.S..-I.AKNS..H..KP.E.....KFR....... 0 0 0 13 20 0 0 0 33 29 87% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN...R.EKP.E.....R.R...RL.. 0 0 4 27 0 0 0 0 31 21 67% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478E,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.ITN---S.S.S.S..-I.AKNS..H.IKP.E.I...K.R....... 0 0 1 1 23 0 0 5 30 11 36% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...K.-....... 0 0 0 25 0 0 0 1 26 1 3% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681-,A684X,R685X,S686X,V687X,A688X,S689X,Q690X,S691X,I692X,I693X,A694X,Y695X,T696X,M697X,S698X,L699X,G700X,A701X,E702X,N703X,S704X,V705X,A706X,Y707X,S708X,+708X,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...K.H....... 0 1 9 10 2 0 1 0 23 9 39% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681H,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT.---S-..S..LS-ITAKN...R.KKPDE.....K.R...RLV. 0 0 1 22 0 0 0 0 23 8 34% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L,A1174V]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...KYR....... 0 0 11 4 1 0 7 0 23 18 78% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680Y,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.S.S..-IKAKNS..H.IKP.E.....K.R....... 0 0 2 0 13 0 0 7 22 9 40% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,T51A,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346K,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITNSNQSP..SR..S-ITAKN..RR.KKPDE.I...K.R....... 0 0 22 0 0 0 0 0 22 11 50% [T19I,R21T,T22N,L24S,P25N,P26Q,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.S.S..-I.AKNS..P.IKP.E.....K.R....... 0 0 1 1 17 0 0 1 20 8 40% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
........P..SR..S-ITAKN..RR.KKPDE.I...K.R....... 0 0 19 0 0 0 0 1 20 16 80% [S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S..TAKN..RR.KKPDE.I...KPR....... 0 0 5 0 0 0 14 0 19 10 52% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,V213G,L216F,L229X,P230X,I231X,G232X,I233X,N234X,I235X,T236X,R237X,F238X,Q239X,T240X,L241X,L242X,A243X,L244X,H245X,R246X,S247X,Y248X,L249X,T250X,P251X,G252X,D253X,S254X,S255X,S256X,G257X,W258X,T259X,A260X,G261X,A262X,A263X,A264X,Y265X,Y266X,V267X,G268X,Y269X,L270X,Q271X,P272X,R273X,T274X,F275X,L276X,L277X,K278X,Y279X,N280X,E281X,N282X,G283X,T284X,I285X,T286X,D287X,A288X,V289X,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.S.S..-ITAKNS..H.IKP.E.....K.R....... 0 0 0 5 11 0 0 1 17 6 35% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I.....R....... 0 1 5 8 3 0 0 0 17 10 58% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.L.S..-I.AKNS..H.IKP.E.....K.R....... 0 0 4 3 9 0 0 1 17 8 47% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157L,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN...R.EKP.E.....R.R....L.L 0 0 0 15 0 0 0 1 16 12 75% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478E,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L,V1264L]
.ITN---S.S.S.S..-I.AKNS..H.IKP.E.....KFR....... 0 0 0 1 7 0 0 8 16 10 62% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680F,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDETI..LK.R......L 0 0 1 14 0 0 0 0 15 13 86% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,K529T,E554K,A570V,T572I,D614G,P621S,H655Y,Q677L,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.ITN---SP..SR..S-ITAKN..RP..KP.......K.RR....V. 0 5 4 6 0 0 0 0 15 5 33% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445P,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,G946R,Q954H,N969K,P1143L,A1174V]
.ITN---SP..SR..S-ITAKN.RRPVKKP.......K.R....... 0 1 3 9 0 1 0 1 15 6 40% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,L441R,K444R,V445P,G446S,N450D,L452W,L455S,F456L,N460K,A475V,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S-..S..LS-ITAKN...RVKKP.E.....K.R...RL.. 0 4 11 0 0 0 0 0 15 11 73% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,A475V,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.ITN---SP..LR..S-ITAKN..RR.KKPDE.I...K.R....... 0 0 5 7 0 0 1 1 14 11 78% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157L,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.VTN---SP..SR..S-ITAKN.R.PVKKP.......K.R......L 0 0 5 9 0 0 0 0 14 11 78% [+16MPLF,T19V,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,L441R,V445P,G446S,N450D,L452W,L455S,F456L,N460K,A475V,S477N,T478K,N481K,V483-,E484K,F486P,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,T791A,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.ITN---S.S.S.S..-I.AKNS..H.IKP.E.......R....... 0 0 2 2 10 0 0 0 14 7 50% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT.---S-..S..LS-ITAKN...R.KKP.E.I...R.R...RL.. 0 0 1 13 0 0 0 0 14 8 57% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.ITN---S-..S..LS-ITAKN...R.KKPDE.I...K.R...RLV. 0 0 5 6 2 0 0 0 13 3 23% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L,A1174V]
.ITN---S.S.S.S.....AKNS..H.IKP.E.....K.R....... 0 0 10 1 1 0 1 0 13 8 61% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..SR..S-I-AKN..RR.KKPDE.I...K.R....... 0 0 6 7 0 0 0 0 13 3 23% [T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,G219D,H245N,A264D,I332V,G339H,+344S,R346-,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT.---S-..S..LS-ITAKN...R.KKP.E.....K.R...RL.. 0 0 4 4 0 0 5 0 13 4 30% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,A522P,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.ITN---S.S.S.S..-I.AKNS..H.IKP.E.....K.H....... 0 0 2 1 8 0 0 1 12 6 50% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681H,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.S.S..-I.AKNS..H.IKP.E.....K.R......L 0 0 2 0 7 0 0 3 12 5 41% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L,V1264L]
.ITN---SP..SR..S-ITA.N..RR.KKPDE.I...K.R....... 0 0 9 3 0 0 0 0 12 5 41% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.S.S..-I.AKNS..H..KP.E.I...K.R....... 0 0 1 2 8 0 0 0 11 5 45% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A260T,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440R,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.IT.---S-..S..LS-ITAKN...R.EKP.E.....R.R...RL.. 0 0 2 8 0 0 1 0 11 3 27% [+16MPLF,T19I,R21T,L24-,P25-,P26-,A27S,S31-,S50L,H69-,V70-,P85S,V127F,N137K,G142D,Y144-,F157S,R158G,F186L,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478E,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679R,P681R,N764K,D796Y,S939F,Q954H,N969K,K1086R,V1104L,P1143L]
.ITN---SP..SR..S-ITAKNS..H.KKP.E.....K.R....L.. 0 5 5 1 0 0 0 0 11 4 36% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.ITN---S.S.SN...-ITAKN...R..KP.E.....K.R....L.. 0 0 0 10 0 0 0 0 10 4 40% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182N,N211-,L212I,V213G,L216F,T240I,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.ITN---SP..SR..S-ITAKN..RR.KKPDE.I...K.R....L.. 0 3 7 0 0 0 0 0 10 3 30% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,V1104L,P1143L]
.ITN---S.S.S.S..-I.AKNS..H.IKP.E.I.....R....... 0 0 4 4 0 0 0 2 10 5 50% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---S.S.S.S..-I.AKNS..H.IKP.E.....KPR....... 0 0 1 0 2 0 0 7 10 4 40% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S50L,F59S,H69-,V70-,V127F,G142D,Y144-,F157S,R158G,G184S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,A435S,N440K,V445H,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478I,N481K,V483-,E484K,F486P,Q493E,Q498R,N501Y,Y505H,E554K,A570V,D614G,P621S,H655Y,N679K,S680P,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP...R..S-ITAK...RR.KKPDE.I...K.R....... 0 0 10 0 0 0 0 0 10 6 60% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,Y144-,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
.ITN---SP..AR..S-ITAKN..RR.KKPDE.I...K.R....... 0 0 1 9 0 0 0 0 10 7 70% [+16MPLF,T19I,R21T,T22N,L24-,P25-,P26-,A27S,S31P,S50L,H69-,V70-,V127F,G142D,Y144-,F157A,R158G,K182R,R190S,N211-,L212I,V213G,L216F,H245N,A264D,I332V,G339H,R346T,K356T,S371F,S373P,S375F,T376A,R403K,D405N,R408S,K417N,N440K,K444R,V445R,G446S,N450D,L452W,L455S,F456L,N460K,S477N,T478K,N481K,V483-,E484K,F486P,N487D,Q493E,Q498R,N501Y,Y505H,E554K,A570V,T572I,D614G,P621S,H655Y,N679K,P681R,N764K,D796Y,S939F,Q954H,N969K,P1143L]
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last modified: Wed May 24 14:07 2023
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