The Spike Features search interface provides the coordinates of known antibody contact sites and antibody-related features. The data from this database are also displayed on the analysis page of the COV CATNAP neutralization database. These sites are often associated with antibody-driven escape.
The commonly-used name of the monoclonal antibody.
The reference(s) from which the information was obtained. There may be other references that have been important in elucidating the antibody or feature, but we only list the reference from which we obtained the data shown.
The type of site:
The experimental method(s) used to define the feature.
Search for mAbs by the protein that the mAb binds to. The protein name includes the RBD binding class, if known. Binding classes are as defined by Barnes et al. 2020 PMID 33045718. The class given is typically taken from subsequent publications specific that the mAb.
Search for Abs by their epitope group. Epitope groups are as defined by Cao et al. 2022 PMID 35016194.
The coordinate of the amino acid where the contact or feature occurs. The coordinates are numbered based on the Spike Wuhan-Hu-1 reference sequence (GenBank NC_045512).
Input allows searching for a single amino acid position, or multiple comma-separated values, for example: 312,313,314,410
Free input text that will search the annotation text. For example, a search for "hydrogen" will find features involving hydrogen bonds.
An arbitrary database ID for each feature.
Initial search results will show a list of features matching the search criteria. Clicking on Details will show the following:
A list of the positions for this feature.
The amino acid at this position in the Spike reference sequence.
Descriptive information about the feature. For example, the description for neutralization features will normally state whether a particular mutation increases or decreases neutralization.
Spike Features search interface
COV CATNAP search interface
Downloads for COV CATNAP and Spike Feature databases